Zobrazeno 1 - 10
of 144
pro vyhledávání: '"A T Magis"'
Autor:
Laura Heath, John C. Earls, Andrew T. Magis, Sergey A. Kornilov, Jennifer C. Lovejoy, Cory C. Funk, Noa Rappaport, Benjamin A. Logsdon, Lara M. Mangravite, Brian W. Kunkle, Eden R. Martin, Adam C. Naj, Nilüfer Ertekin-Taner, Todd E. Golde, Leroy Hood, Nathan D. Price, Alzheimer’s Disease Genetics Consortium
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Genetics play an important role in late-onset Alzheimer’s Disease (AD) etiology and dozens of genetic variants have been implicated in AD risk through large-scale GWAS meta-analyses. However, the precise mechanistic effects of most of thes
Externí odkaz:
https://doaj.org/article/16f2fcd1b96e47098d8b9f2e9f36d3ec
Autor:
Anat Zimmer, Yael Korem, Noa Rappaport, Tomasz Wilmanski, Priyanka Baloni, Kathleen Jade, Max Robinson, Andrew T. Magis, Jennifer Lovejoy, Sean M. Gibbons, Leroy Hood, Nathan D. Price
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Longitudinal multi-omics measurements are highly valuable in studying heterogeneity in health and disease phenotypes. Here, the authors apply Pareto Task Inference to analyze the clinical lab tests of 3094 individuals and find three wellness states,
Externí odkaz:
https://doaj.org/article/3bc217cadb6347bdb67f294b25377a9c
Autor:
Ohad Manor, Chengzhen L. Dai, Sergey A. Kornilov, Brett Smith, Nathan D. Price, Jennifer C. Lovejoy, Sean M. Gibbons, Andrew T. Magis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Variation in the gut microbiome can reflect host lifestyle, behaviour, and influence blood-based biomarkers. Here the authors examine associations between the microbiota and 150 host phenotypic features in a large cohort of >3,000 individuals.
Externí odkaz:
https://doaj.org/article/0052447521b44774a80d4a479041f1cc
Autor:
Christian Diener, Shizhen Qin, Yong Zhou, Sushmita Patwardhan, Li Tang, Jennifer C. Lovejoy, Andrew T. Magis, Nathan D. Price, Leroy Hood, Sean M. Gibbons
Publikováno v:
mSystems, Vol 6, Iss 5 (2021)
ABSTRACT Recent human feeding studies have shown how the baseline taxonomic composition of the gut microbiome can determine responses to weight loss interventions. However, the functional determinants underlying this phenomenon remain unclear. We rep
Externí odkaz:
https://doaj.org/article/125b97e2651045658d5ed82772208e29
Autor:
Sergey A. Kornilov, Isabelle Lucas, Kathleen Jade, Chengzhen L. Dai, Jennifer C. Lovejoy, Andrew T. Magis
Publikováno v:
Critical Care, Vol 24, Iss 1, Pp 1-3 (2020)
Externí odkaz:
https://doaj.org/article/848d70935464475aadd4f5182f0a6569
Autor:
Ke Xu, Dongkyoo Park, Andrew T. Magis, Jun Zhang, Wei Zhou, Gabriel L. Sica, Suresh S. Ramalingam, Walter J. Curran, Xingming Deng
Publikováno v:
Molecular Cancer, Vol 18, Iss 1, Pp 1-16 (2019)
Abstract Background Lung cancer patients with KRAS mutation(s) have a poor prognosis due in part to the development of resistance to currently available therapeutic interventions. Development of a new class of anticancer agents that directly targets
Externí odkaz:
https://doaj.org/article/3f768d5575f04b929f12a8fef492e1de
Autor:
Kengo Watanabe, Tomasz Wilmanski, Christian Diener, John C. Earls, Anat Zimmer, Briana Lincoln, Jennifer J. Hadlock, Jennifer C. Lovejoy, Sean M. Gibbons, Andrew T. Magis, Leroy Hood, Nathan D. Price, Noa Rappaport
Publikováno v:
Nature Medicine. 29:996-1008
Multiomic profiling can reveal population heterogeneity for both health and disease states. Obesity drives a myriad of metabolic perturbations and is a risk factor for multiple chronic diseases. Here we report an atlas of cross-sectional and longitud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62bad2f5a3cb955a3bdca687fe7271bd
https://doi.org/10.1038/s41591-023-02248-0
https://doi.org/10.1038/s41591-023-02248-0
Autor:
T. Francois, J. Coignus, A. Makosiej, B. Giraud, C. Carabasse, J. Barbot, S. Martin, N. Castellani, T. Magis, H. Grampeix, S. Van Duijn, C. Mounet, P. Chiquet, U. Schroeder, S. Slesazeck, T. Mikolajick, E. Nowak, M. Bocquet, N. Barrett, F. Andrieu, L. Grenouillet
Publikováno v:
IEEE Transactions on Electron Devices. 69:2108-2114
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ddb7a9963ca4b47a8c518521edbaeab
https://doi.org/10.1109/ted.2021.3138360
https://doi.org/10.1109/ted.2021.3138360
Autor:
Xingming Deng, Jia Zhou, Dong M. Shin, Taofeek K. Owonikoko, Walter J. Curran, Fadlo R. Khuri, Haian Fu, Andrew T. Magis, Suresh S. Ramalingam, Gabriel L. Sica, Zhuo G. Chen, Shi-Yong Sun, Adam I. Marcus, Wei Zhou, Melissa Gilbert-Ross, Guojing Zhang, Guo Chen, Ye Ding, Dongkyoo Park, Maohua Xie, Jun Zhang, Chunyong Ding, Rui Li
Figure S1. Bak BH3 peptide position in Bak protein. Figure S2. Dephosphorylation of Bax by lambdaPPase in vitro. Figure S3. Bax activators CYD-2-11 and SMBA1 failed to induce Bak oligomerization. Figure S4. Analysis of CYD-2-11 toxicity in vivo. Figu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a436a52529dc1a5ba872a0d0b3d2e0
https://doi.org/10.1158/0008-5472.22414932
https://doi.org/10.1158/0008-5472.22414932
Autor:
Xingming Deng, Jia Zhou, Dong M. Shin, Taofeek K. Owonikoko, Walter J. Curran, Fadlo R. Khuri, Haian Fu, Andrew T. Magis, Suresh S. Ramalingam, Gabriel L. Sica, Zhuo G. Chen, Shi-Yong Sun, Adam I. Marcus, Wei Zhou, Melissa Gilbert-Ross, Guojing Zhang, Guo Chen, Ye Ding, Dongkyoo Park, Maohua Xie, Jun Zhang, Chunyong Ding, Rui Li
A rationale exists for pharmacologic manipulation of the serine (S)184 phosphorylation site of the proapoptotic Bcl2 family member Bax as an anticancer strategy. Here, we report the refinement of the Bax agonist SMBA1 to generate CYD-2-11, which has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d09e6f8b4e77f32ca61f6be4c27d83d
https://doi.org/10.1158/0008-5472.c.6509121.v1
https://doi.org/10.1158/0008-5472.c.6509121.v1