Zobrazeno 1 - 10 of 706 pro vyhledávání: '"A T, Taher"'
1
Akademický článek
Identifying thresholds for meaningful improvements in NTDT-PRO scores to support conclusions about treatment benefit in clinical studies of patients with non-transfusion-dependent beta-thalassaemia: analysis of pooled data from a phase 2, double-blind, placebo-controlled, randomised trial
Autor: Ali T Taher, Maria Domenica Cappellini, Khaled M Musallam, Vip Viprakasit, Antonis Kattamis, Jennifer Lord-Bessen, Aylin Yucel, Shien Guo, Alan L Shields, Jeevan K Shetty, Luciana Moro Bueno, Christopher G Pelligra, Mrudula B Glassberg
Publikováno v: BMJ Open, Vol 14, Iss 11 (2024)
Objectives To estimate thresholds for defining meaningful within-patient improvement from baseline to weeks 13–24 and interpreting meaningfulness of between-group difference for the non-transfusion-dependent beta-thalassaemia patient-reported outco
Externí odkaz: https://doaj.org/article/50d6dec36fcb41b2b1d5bd4ebebaf1bd
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2
Akademický článek
Design and synthesis of some new benzoylthioureido benzenesulfonamide derivatives and their analogues as carbonic anhydrase inhibitors
Autor: Khulood H. Oudah, Walaa R. Mahmoud, Fadi M. Awadallah, Azza T. Taher, Safinaz E.-S Abbas, Heba Abdelrasheed Allam, Daniela Vullo, Claudiu T. Supuran
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 12-23 (2023)
The present investigation reports the design and synthesis of three series of benzoylthioureido derivatives bearing either benzenesulfonamide 7a–f, benzoic acid 8a–f or ethylbenzoate 9a–f moieties. The synthesised compounds were screened for th
Externí odkaz: https://doaj.org/article/9079e92375a74694abaf13dca32085d8
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3
Akademický článek
Compliance and clinical benefit of deferasirox granule and dispersible tablet formulation in pediatric patients with transfusional iron overload: in a randomized, open-label, multicenter, phase II study
Autor: Ali T. Taher, Yasser Wali, Maria Cecilia Cruz, Pimlak Charoenkwan, Yesim Aydinok, Olena Werner, Sameera Govindaraju, Fabian Romen, Vip Viprakasit
Publikováno v: Haematologica, Vol 109, Iss 5 (2023)
CALYPSO (clinicaltrials gov. Identifier: NCT02435212), a randomized, open-label, multicenter, phase II study evaluated the compliance, clinical benefits, and safety of deferasirox granules and dispersible tablets (DT) in pediatric patients with iron
Externí odkaz: https://doaj.org/article/3ac9ea4995e4411f82eb7796e45ca40e
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4
Akademický článek
Cardiovascular Complications in β-Thalassemia: Getting to the Heart of It
Autor: Nathalie Akiki, Mohammad H. Hodroj, Rayan Bou-Fakhredin, Kamal Matli, Ali T. Taher
Publikováno v: Thalassemia Reports, Vol 13, Iss 1, Pp 38-50 (2023)
Beta thalassemia is an inherited disorder resulting in abnormal or decreased production of hemoglobin, leading to hemolysis and chronic anemia. The long-term complications can affect multiple organ systems, namely the liver, heart, and endocrine. Myo
Externí odkaz: https://doaj.org/article/fc3b3527f045428292e6679dcb2072e1
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5
Akademický článek
Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes
Autor: Mazin A. A. Najm, Walaa R. Mahmoud, Azza T. Taher, Safinaz E-S. Abbas, Fadi M. Awadallah, Heba Abdelrasheed Allam, Daniela Vullo, Claudiu T. Supuran
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2702-2709 (2022)
The present study aimed to develop potent carbonic anhydrase inhibitors (CAIs). The design of the target compounds was based on modifying the structure of the ureido-based carbonic anhydrase inhibitor SLC-0111. Six series of a substituted benzoylthio
Externí odkaz: https://doaj.org/article/c435c9c5839048bfb876e8744a19fddd
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9
Akademický článek
New potential anti-SARS-CoV-2 and anti-cancer therapies of chitosan derivatives and its nanoparticles: Preparation and characterization
Autor: Mai Ali, Mansoura I. Mohamed, Azza T. Taher, Sara H. Mahmoud, Ahmed Mostafa, Farag F. Sherbiny, Nadia G. Kandile, Hemat M. Mohamed
Publikováno v: Arabian Journal of Chemistry, Vol 16, Iss 5, Pp 104676- (2023)
Chitosan (CS) is a biopolymer and has reactive amine/hydroxyl groups facilitated its modifications. The purpose of this study is improvement of (CS) physicochemical properties and its capabilities as antiviral and antitumor through modification with
Externí odkaz: https://doaj.org/article/4206a22aadb84e5a951a54d4a12ff3c5
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10
Akademický článek
Random Forest Clustering Identifies Three Subgroups of β-Thalassemia with Distinct Clinical Severity
Autor: Angela Vitrano, Khaled M. Musallam, Antonella Meloni, Sebastiano Addario Pollina, Mehran Karimi, Amal El-Beshlawy, Mahmoud Hajipour, Vito Di Marco, Saqib Hussain Ansari, Aldo Filosa, Paolo Ricchi, Adriana Ceci, Shahina Daar, Efthymia Vlachaki, Sylvia Titi Singer, Zaki A. Naserullah, Alessia Pepe, Salvatore Scondotto, Gabriella Dardanoni, Fedele Bonifazi, Vijay G. Sankaran, Elliott Vichinsky, Ali T. Taher, Aurelio Maggio, International Working Group on Thalassemia (IWG-THAL)
Publikováno v: Thalassemia Reports, Vol 12, Iss 1, Pp 14-23 (2022)
In this work, we aimed to establish subgroups of clinical severity in a global cohort of β-thalassemia through unsupervised random forest (RF) clustering. We used a large global dataset of 7910 β-thalassemia patients and evaluated 19 indicators of
Externí odkaz: https://doaj.org/article/aa15c48822b849b987d37e3cf47bfde0
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