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Akademický článek

AIB1/SRC-3/NCOA3 function in estrogen receptor alpha positive breast cancer

Autor: Amber J. Kiliti, Ghada M. Sharif, Mary Beth Martin, Anton Wellstein, Anna T. Riegel

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

The estrogen receptor alpha (ERα) is a steroid receptor that is pivotal in the initiation and progression of most breast cancers. ERα regulates gene transcription through recruitment of essential coregulators, including the steroid receptor coactiv

Externí odkaz: https://doaj.org/article/90cddbfd1f0747c8873604d460509976

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Akademický článek

Circulating cell-free methylated DNA reveals tissue-specific, cellular damage from radiation treatment

Autor: Megan E. McNamara, Netanel Loyfer, Amber J. Kiliti, Marcel O. Schmidt, Sapir Shabi-Porat, Sidharth S. Jain, Sarah Martinez Roth, A. Patrick McDeed IV, Nesreen Shahrour, Elizabeth Ballew, Yun-Tien Lin, Heng-Hong Li, Anne Deslattes Mays, Sonali Rudra, Anna T. Riegel, Keith Unger, Tommy Kaplan, Anton Wellstein

Publikováno v: JCI Insight, Vol 8, Iss 14 (2023)

Radiation therapy is an effective cancer treatment, although damage to healthy tissues is common. Here we analyzed cell-free, methylated DNA released from dying cells into the circulation to evaluate radiation-induced cellular damage in different tis

Externí odkaz: https://doaj.org/article/0eb9bcb8aa8b40a4ba4c47c4e39aa949

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Akademický článek

Impaired CXCL12 signaling contributes to resistance of pancreatic cancer subpopulations to T cell-mediated cytotoxicity

Autor: Yuan-Na Lin, Marcel O. Schmidt, Ghada M. Sharif, Eveline E. Vietsch, Amber J. Kiliti, Megan E. Barefoot, Anna T. Riegel, Anton Wellstein

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

Pancreatic cancer remains largely unresponsive to immune modulatory therapy attributable in part to an immunosuppressive, desmoplastic tumor microenvironment. Here, we analyze mechanisms of cancer cell-autonomous resistance to T cells. We used a 3D c

Externí odkaz: https://doaj.org/article/2d24f4c980be417c897fa5b984546e5d

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Akademický článek

Cardiomyocyte-Specific Circulating Cell-Free Methylated DNA in Esophageal Cancer Patients Treated with Chemoradiation

Autor: Sarah Martinez Roth, Eveline E. Vietsch, Megan E. Barefoot, Marcel O. Schmidt, Matthew D. Park, Archana Ramesh, Michael R. Lindberg, Giuseppe Giaccone, Anna T. Riegel, Ana Barac, Keith Unger, Anton Wellstein

Publikováno v: Gastrointestinal Disorders, Vol 3, Iss 3, Pp 100-112 (2021)

Thoracic high-dose radiation therapy (RT) for cancer has been associated with early and late cardiac toxicity. To assess altered rates of cardiomyocyte cell death due to RT we monitored changes in cardiomyocyte-specific, cell-free methylated DNA (cfD

Externí odkaz: https://doaj.org/article/44f090ede39b42859e5a5e78d9c4ff96

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Akademický článek

Low Dose Chronic Angiotensin II Induces Selective Senescence of Kidney Endothelial Cells

Autor: Irfan Khan, Marcel O. Schmidt, Bhaskar Kallakury, Sidharth Jain, Shaunt Mehdikhani, Moshe Levi, Margarida Mendonca, William Welch, Anna T. Riegel, Christopher S. Wilcox, Anton Wellstein

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Angiotensin II can cause oxidative stress and increased blood pressure that result in long term cardiovascular pathologies. Here we evaluated the contribution of cellular senescence to the effect of chronic exposure to low dose angiotensin II in a mo

Externí odkaz: https://doaj.org/article/d41988e59090480dbfe41577baebf916

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Akademický článek

321 Impact of CDK4/6 inhibitor-induced cellular senescence on stromal responses to breast cancer

Autor: Gregory T. Gallanis, Anton Wellstein, Anna T. Riegel

Publikováno v: Journal of Clinical and Translational Science, Vol 6, Pp 57-57 (2022)

OBJECTIVES/GOALS: The objective of my study is to test my overall hypothesis that CDK4/6 inhibitor-induced cellular senescence has long-lasting consequences on the tumor microenvironment that affect tumor growth and disease progression. METHODS/STUDY

Externí odkaz: https://doaj.org/article/d502aac4adfc4bb9af0e672590102869

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