Zobrazeno 1 - 10
of 43
pro vyhledávání: '"A T, Koki"'
Publikováno v:
Science and Technology of Welding and Joining. 18:38-44
In fusion welding, gravity makes a molten metal flow downward and it sometimes causes an irregular shaped weld bead and weld defects such as an undercut. To solve this problem, the authors propose a new electromagnetic controlled molten pool welding
Autor:
Khaldoun G. Tarakji, Bradley T. Keller, Ming Zhang, Eric J. Topol, A. Michael Lincoff, Farhad Forudi, Zhongmin Zhou, Mark E. Smith, Xiaorong Zhou, Alane T. Koki, Kai Wang, Marc S. Penn
Publikováno v:
Journal of Cardiovascular Pharmacology. 45:61-67
The inflammation in response to vascular injury is becoming increasingly recognized as a potential contributor to restenosis. Cyclooxygenase-2 (COX-2) is the inducible form of cyclooxygenase and has been shown to be involved in the proinflammatory re
Autor:
Anne-Christine Goulet, Janet M. Harmon, Janine Einsphar, Achyut K. Bhattacharyya, Mark A. Nelson, Jerry L. Bangert, Anthony Beas, David S. Alberts, Hideji Fujiwara, Cynthia Burk, Alane T. Koki
Publikováno v:
Cancer Biology & Therapy. 2:711-716
Cyclooxygenase 2 (COX-2) is an inducible enzyme involved in the production of prostaglandins and thromboxanes during inflammation. There are now several lines of evidence indicating that increased expression of COX-2 plays a functional role in the de
Autor:
Ben S. Zweifel, Donna F. Kusewitt, Traci A. Wilgus, Patricia A. Rubal, Alane T. Koki, Tatiana M. Oberyszyn
Publikováno v:
Molecular Carcinogenesis. 38:49-58
Inflammation, which includes the release of growth factors, proinflammatory cytokines and prostaglandins, the infiltration and activation of inflammatory cells, and the induction of oxidative DNA damage, is known to play a role in cancer development.
Publikováno v:
Molecular Carcinogenesis. 38:33-39
Over a million nonmelanoma skin cancer cases will be reported in the United States this year alone. Currently the primary form of treatment for these types of skin tumors is excision. However, excision of the initial lesion may not be curative becaus
Autor:
Alane T. Koki, Jaime L. Masferrer
Publikováno v:
Cancer Control. 9:28-35
In addition to the well-established pathophysiological role that COX-2 plays in inflammation, recent evidence implies that this isoform may also be involved in multiple biologic events throughout the tumorigenic process. Many epidemiological studies
Autor:
Vicente Arroyo, Francisca Rivera, Wladimiro Jiménez, Marta López-Parra, Joan Clària, Anna Planagumà, Jaime L. Masferrer, Esther Titos, Rosario Altuna, Alane T. Koki, Joan Rodés, B. Mark Woerner
Publikováno v:
British Journal of Pharmacology. 135:891-900
1. The maintenance of renal function in decompensated cirrhosis is highly dependent on prostaglandins (PGs). Since PG synthesis is mediated by cyclooxygenase-1 and -2 (COX-1 and COX-2), the present study was designed to examine which COX isoform is i
Autor:
Lisa M. Olson, Katherine C. Harris, Yoel Sadovsky, Louis J. Muglia, Alane T. Koki, Gilad A. Gross, D. Michael Nelson, Jaime L. Masferrer
Publikováno v:
American Journal of Obstetrics and Gynecology. 182:370-376
Objective: Cyclooxygenase inhibitors are effective tocolytic agents, but significant adverse effects limit their use. We hypothesized that selective inhibitors of the isozyme cyclooxygenase 2 would effectively diminish labor-associated prostaglandin
Autor:
B. M. Woerner, J. L. Masferrer, Demaretta S. Rush, Robert A. Soslow, Alane T. Koki, K. Nasir Khan, Andrew J. Dannenberg
Publikováno v:
Cancer. 89:2637-2645
BACKGROUND The cyclooxygenase (COX) enzyme catalyzes the formation of prostaglandins, which can affect cell proliferation and alter the response of the immune system to malignant cells. The inducible form of COX, COX-2, has been shown to be important
Publikováno v:
Expert Opinion on Investigational Drugs. 8:1623-1638
Increased prostaglandin (PG) production is associated with many inflammatory pathophysiological conditions; it is derived from arachidonic acid by either of two enzymes: cyclooxygenase-1 or -2 (COX-1 or COX-2). In addition to its role in inflammation