Výsledky vyhledávání - "A T, Jacovina"

Autor: Andrew T. Jacovina, Katherine A. Hajjar, Carrie Brownstein, Domenick J. Falcone

Publikováno v: Annals of the New York Academy of Sciences. 947:143-156

It has become increasingly evident that the generation of cell surface proteases including plasmin is fundamental to a wide variety of in vivo biological processes. Cell surface receptors allow for specific controlled proteolysis, provide protection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::293e9378e873b0516aab06409aed27f2
https://doi.org/10.1111/j.1749-6632.2001.tb03937.x

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An Annexin 2 Phosphorylation Switch Mediates p11-dependent Translocation of Annexin 2 to the Cell Surface

Autor: Andrew T. Jacovina, Arunkumar B. Deora, Katherine A. Hajjar, Geri Kreitzer

Publikováno v: Journal of Biological Chemistry. 279:43411-43418

Annexin 2 is a profibrinolytic co-receptor for plasminogen and tissue plasminogen activator that stimulates activation of the major fibrinolysin, plasmin, at cell surfaces. In human subjects, overexpression of annexin 2 in acute promyelocytic leukemi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac7692349bcde6553d88e84126ebf6a
https://doi.org/10.1074/jbc.m408078200

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Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo

Autor: Andrew T. Jacovina, Arunkumar B. Deora, Maria Febbraio, Ronit Simantov, Barbara L. Hempstead, Qi Ling, Willie Mark, Katherine A. Hajjar, Roy L. Silverstein

Publikováno v: Journal of Clinical Investigation. 113:38-48

A central tenet of fibrinolysis is that tissue plasminogen activator–dependent (t-PA– dependent) conversion of plasminogen to active plasmin requires the presence of the cofactor/substrate fibrin. However, previous in vitro studies have suggested

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5575840c4c8c3dd0d02d9debc4e64b99
https://doi.org/10.1172/jci19684

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Annexin II mediates plasminogen-dependent matrix invasion by human monocytes: enhanced expression by macrophages

Autor: Domenick J. Falcone, K.M. Faisal Khan, Arunkumar B. Deora, Andrew T. Jacovina, Menard M. Gertler, Rebecca Weintraub, Katherine A. Hajjar, Carrie Brownstein

Publikováno v: Blood. 103:317-324

Monocytes and macrophages participate in a wide variety of host defense mechanisms. Annexin II, a fibrinolytic receptor, binds plasminogen and tissue plasminogen activator (t-PA) independently at the cell surface, thereby enhancing the catalytic effi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0b978105c8d07fa8c69c31421d029b
https://doi.org/10.1182/blood-2003-04-1304

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Tissue Plasminogen Activator Binding to the Annexin II Tail Domain

Autor: Andrew T. Jacovina, Brian T. Chait, Fengming Zhong, Katherine A. Hajjar, Julio C. Padovan, Laura Mauri, Urooj A. Mirza

Publikováno v: Journal of Biological Chemistry. 273:9987-9993

Tissue plasminogen activator binds to endothelial cells via the calcium-regulated phospholipid-binding protein annexin II, an interaction that is inhibited by the prothrombotic amino acid homocysteine. We sought to identify the tissue plasminogen act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92e358119c6782b143eb4c7316189e57
https://doi.org/10.1074/jbc.273.16.9987

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An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II

Autor: Andrew T. Jacovina, Katherine A. Hajjar, J Chacko

Publikováno v: Journal of Biological Chemistry. 269:21191-21197

Sequencing of two internal peptides from the putative human endothelial cell tissue plasminogen activator (t-PA) receptor identified an analog of the calcium- and phospholipid-binding protein, annexin II (Ann-II). The polymerase chain reaction-derive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61632384b9e0197cd21b16741fbf1bb6
https://doi.org/10.1016/s0021-9258(17)31947-6

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Homocysteine inhibits neoangiogenesis in mice through blockade of annexin A2–dependent fibrinolysis

Autor: Dena Almeida, Jonathan D. Smith, Arunkumar B. Deora, Qi Ling, M. Johan Broekman, Aaron J. Marcus, Caroline B. Greenberg, Katherine A. Hajjar, Andrew T. Jacovina

Publikováno v: Journal of Clinical Investigation.

When plasma levels of homocysteine (HC), a thiol amino acid formed upon methionine demethylation, exceed 12 muM, individuals are at increased risk of developing large vessel atherothrombosis and small vessel dysfunction. The annexin A2 complex (terme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929b93351df0d16ac0b7d32a5d8bec24
https://doi.org/10.1172/jci39591

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A prototype antibody microarray platform to monitor changes in protein tyrosine phosphorylation

Autor: Dmitry S. Gembitsky, Paul Tempst, Kevin Lawlor, Mariana Yaneva, Andrew T. Jacovina

Publikováno v: Molecularcellular proteomics : MCP. 3(11)

Reversible protein phosphorylation is a key regulatory process in all living cells. Deregulation of modification control mechanisms, especially in the case of tyrosine, may lead to malignant transformation and disease. Phosphotyrosine (p-Tyr) account

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c463650fe37b09cf1817b9f422f851b
https://pubmed.ncbi.nlm.nih.gov/15358805

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