BUB1B monoallelic germline variants contribute to prostate cancer predisposition by triggering chromosomal instability

Autor: Maria P. Silva, Luísa T. Ferreira, Natércia F. Brás, Lurdes Torres, Andreia Brandão, Manuela Pinheiro, Marta Cardoso, Adriana Resende, Joana Vieira, Carlos Palmeira, Gabriela Martins, Miguel Silva, Carla Pinto, Ana Peixoto, João Silva, Rui Henrique, Sofia Maia, Helder Maiato, Manuel R. Teixeira, Paula Paulo

Publikováno v: Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-17 (2024)

Abstract Background Prostate cancer (PrCa) is the most frequently diagnosed cancer in men. Variants in known moderate- to high-penetrance genes explain less than 5% of the cases arising at early-onset (

Externí odkaz: https://doaj.org/article/89556ac24efa46d1a230f329bd5bf87d

Incidence, management and outcomes in hepatic artery complications after paediatric liver transplantation: protocol of the retrospective, international, multicentre HEPATIC Registry

Autor: Barbara E Wildhaber, Wei Zhang, Martin de Santibañes, Victoria Ardiles, Xueli Bai, Mukesh Kumar, Mohamed Rela, Reinoud P H Bokkers, Ekkehard Sturm, Simon McGuirk, Girish Gupte, Esteban Frauca, Francisco Hernández-Oliveros, Winita Hardikar, Helen Evans, Khalid Sharif, Jiří Froněk, David Duncan, Emmanuel Gonzales, Carl Jorns, Alessandro Parente, Ulrich Baumann, Lidia Monti, Marco Spada, Denise Aldrian, Hubert P J van der Doef, Thomas Casswall, Martin Delle, Georg F Vogel, Adam Kolesnik, Mauricio Larrarte K, Paolo Marra, Michela Bravi, Domenico Pinelli, Hajime Uchida, Vidyadhar Mali, Marion Aw, Stéphanie Franchi-Abella, Florent Guérin, Julia Minetto, Sergio Sierre, Jimmy Walker Uno, Steffen Hartleif, Cristina T Ferreira, Luiza S Nader, Catalina Jaramillo, Amit A Shah, Michael R Acord, Tommaso Alterio, Marisa Beretta, Haritha Rajakrishnan, Sudhindran Surendran, Weihao Li, Marcelo Dip, Sue Bates, Lynette Goh, Jonathan Seisenbacher, Joao Seda Neto, Eduardo Antunes da Fonseca, Carolina Magalhães Costa, Marco A Farina, Khaled Z Dajani, David L Bigam, Ting-Bo Liang, Lucie Gonsorčíková, Šimon Bohuš, Norman Junge, Nicolas Richter, Muthukumarassamy Rajakannu, Kumar Palaniappan, Arti Pawaria, Shaleen Agarwal, Subhash Gupta, Sonal Asthana, Vaishnavi Bandewar, Karthik Raichurkar, Yusuke Yanagi, Ryuji Komine, Peter Carr-Boyd, Marek Stefanowicz, Julita Latka-Grot, Dieter C Broering, Dimitri A Raptis, Kris Ann H Marquez, Francisca Van der Schyff, Jesús Quintero-Bernabeu, Maria Mercadal-Hally, Ane M Andres, Riccardo Superina, Juan Carlos Caicedo, Leandra Bitterfeld, Zachary Kastenberg, Bryanna Domenick, George V Mazariegos, Kyle Soltys, Joseph DiNorcia, Swanti Antala, Sander S Florman, Bettina M Buchholz, Uta Herden, Lutz Fischer, Rudi A J O Dierckx, Hermien Hartog

Publikováno v: BMJ Open, Vol 14, Iss 6 (2024)

Introduction Hepatic artery complications (HACs), such as a thrombosis or stenosis, are serious causes of morbidity and mortality after paediatric liver transplantation (LT). This study will investigate the incidence, current management practices and

Externí odkaz: https://doaj.org/article/b5c519cf55df4801870085b52149e12e

Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice

Autor: Felipe C. Ribeiro, Danielle Cozachenco, Luana Heimfarth, Juliana T. S. Fortuna, Guilherme B. de Freitas, Jorge M. de Sousa, Soniza V. Alves-Leon, Renata E. P. Leite, Claudia K. Suemoto, Lea T. Grinberg, Fernanda G. De Felice, Mychael V. Lourenco, Sergio T. Ferreira

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)

Abstract The proteasome plays key roles in synaptic plasticity and memory by regulating protein turnover, quality control, and elimination of oxidized/misfolded proteins. Here, we investigate proteasome function and localization at synapses in Alzhei

Externí odkaz: https://doaj.org/article/bdf4804051b140dd9c552fb96120595a

A fatal respiratory complication of malaria caused by Plasmodium vivax

Autor: Angie R. López, Ezequias B. Martins, Anielle de Pina-Costa, Ana Beatriz Pacheco-Silva, Marcel T. Ferreira, Roxana F. Mamani, Paula J. T. Detepo, Otilia Lupi, Clarisse S. Bressan, Guilherme A. Calvet, Michele F. B. Silva, Maria de Fátima Ferreira-da-Cruz, Fernanda de Bruycker-Nogueira, Ana Maria B. Filippis, Cláudio Tadeu Daniel-Ribeiro, André Siqueira, Patrícia Brasil

Publikováno v: Malaria Journal, Vol 22, Iss 1, Pp 1-5 (2023)

Abstract Background Malaria is endemic and represents an important public health issue in Brazil. Knowledge of risk factors for disease progression represents an important step in preventing and controlling malaria-related complications. Reports of s

Externí odkaz: https://doaj.org/article/1faac437952f47788ddc995f568d4d8d

Rheology of Suspensions of TEMPO-Oxidised and Cationic Cellulose Nanofibrils—The Effect of Chemical Pre-Treatment

Autor: Luís Alves, Solange Magalhães, Jorge F. S. Pedrosa, Paulo J. T. Ferreira, José A. F. Gamelas, Maria Graça Rasteiro

Publikováno v: Gels, Vol 10, Iss 6, p 367 (2024)

Cellulose nanofibrils (CNFs) are particles with a high aspect ratio. Typically, chemically pre-treated CNFs (containing anionic or cationic charged groups) consist of long fibrils (up to 2 μm) with very low thickness (less than 10 nm). Derived from

Externí odkaz: https://doaj.org/article/3e652ec85e4541868d92b18d29d5deff