Characterization of innate lymphoid cell subsets infiltrating melanoma and epithelial ovarian tumors

Autor: Douglas C. Chung, Maryam Ghaedi, Kathrin Warner, Azin Sayad, Samuel D. Saibil, Marcus Q. Bernardini, Blaise A. Clarke, Patricia A. Shaw, Marcus O. Butler, Alexandra Easson, Sorana Morrissy, Ben X. Wang, Linh Nguyen, Pamela S. Ohashi, Nicolas Jacquelot

Publikováno v: OncoImmunology, Vol 13, Iss 1 (2024)

The innate lymphoid cell (ILC) family is composed of heterogeneous innate effector and helper immune cells that preferentially reside in tissues where they promote tissue homeostasis. In cancer, they have been implicated in driving both pro- and anti

Externí odkaz: https://doaj.org/article/2c98b09b40254ed59e8229b8fbac0c31

Synapse-specific diversity of distinct postsynaptic GluN2 subtypes defines transmission strength in spinal lamina I

Autor: Graham M. Pitcher, Livia Garzia, A. Sorana Morrissy, Michael D. Taylor, Michael W. Salter

Publikováno v: Frontiers in Synaptic Neuroscience, Vol 15 (2023)

The unitary postsynaptic response to presynaptic quantal glutamate release is the fundamental basis of excitatory information transfer between neurons. The view, however, of individual glutamatergic synaptic connections in a population as homogenous,

Externí odkaz: https://doaj.org/article/a0c76a9183604043a7ada7e2103a6dad

Profiling Chromatin Accessibility at Single-cell Resolution

Autor: Sarthak Sinha, Ansuman T. Satpathy, Weiqiang Zhou, Hongkai Ji, Jo A. Stratton, Arzina Jaffer, Nizar Bahlis, Sorana Morrissy, Jeff A. Biernaskie

Publikováno v: Genomics, Proteomics & Bioinformatics, Vol 19, Iss 2, Pp 172-190 (2021)

How distinct transcriptional programs are enacted to generate cellular heterogeneity and plasticity, and enable complex fate decisions are important open questions. One key regulator is the cell’s epigenome state that drives distinct transcriptiona

Externí odkaz: https://doaj.org/article/5aca11c01c014409a829dd0a2d1013a8

Failure of human rhombic lip differentiation underlies medulloblastoma formation

Autor: Liam D. Hendrikse, Parthiv Haldipur, Olivier Saulnier, Jake Millman, Alexandria H. Sjoboen, Anders W. Erickson, Winnie Ong, Victor Gordon, Ludivine Coudière-Morrison, Audrey L. Mercier, Mohammad Shokouhian, Raúl A. Suárez, Michelle Ly, Stephanie Borlase, David S. Scott, Maria C. Vladoiu, Hamza Farooq, Olga Sirbu, Takuma Nakashima, Shohei Nambu, Yusuke Funakoshi, Alec Bahcheli, J. Javier Diaz-Mejia, Joseph Golser, Kathleen Bach, Tram Phuong-Bao, Patryk Skowron, Evan Y. Wang, Sachin A. Kumar, Polina Balin, Abhirami Visvanathan, John J. Y. Lee, Ramy Ayoub, Xin Chen, Xiaodi Chen, Karen L. Mungall, Betty Luu, Pierre Bérubé, Yu C. Wang, Stefan M. Pfister, Seung-Ki Kim, Olivier Delattre, Franck Bourdeaut, François Doz, Julien Masliah-Planchon, Wieslawa A. Grajkowska, James Loukides, Peter Dirks, Michelle Fèvre-Montange, Anne Jouvet, Pim J. French, Johan M. Kros, Karel Zitterbart, Swneke D. Bailey, Charles G. Eberhart, Amulya A. N. Rao, Caterina Giannini, James M. Olson, Miklós Garami, Peter Hauser, Joanna J. Phillips, Young S. Ra, Carmen de Torres, Jaume Mora, Kay K. W. Li, Ho-Keung Ng, Wai S. Poon, Ian F. Pollack, Enrique López-Aguilar, G. Yancey Gillespie, Timothy E. Van Meter, Tomoko Shofuda, Rajeev Vibhakar, Reid C. Thompson, Michael K. Cooper, Joshua B. Rubin, Toshihiro Kumabe, Shin Jung, Boleslaw Lach, Achille Iolascon, Veronica Ferrucci, Pasqualino de Antonellis, Massimo Zollo, Giuseppe Cinalli, Shenandoah Robinson, Duncan S. Stearns, Erwin G. Van Meir, Paola Porrati, Gaetano Finocchiaro, Maura Massimino, Carlos G. Carlotti, Claudia C. Faria, Martine F. Roussel, Frederick Boop, Jennifer A. Chan, Kimberly A. Aldinger, Ferechte Razavi, Evelina Silvestri, Roger E. McLendon, Eric M. Thompson, Marc Ansari, Maria L. Garre, Fernando Chico, Pilar Eguía, Mario Pérezpeña, A. Sorana Morrissy, Florence M. G. Cavalli, Xiaochong Wu, Craig Daniels, Jeremy N. Rich, Steven J. M. Jones, Richard A. Moore, Marco A. Marra, Xi Huang, Jüri Reimand, Poul H. Sorensen, Robert J. Wechsler-Reya, William A. Weiss, Trevor J. Pugh, Livia Garzia, Claudia L. Kleinman, Lincoln D. Stein, Nada Jabado, David Malkin, Olivier Ayrault, Jeffrey A. Golden, David W. Ellison, Brad Doble, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie, Hiromichi Suzuki, Kathleen J. Millen, Michael D. Taylor

Publikováno v: Nature, 609(7929), 1021-1028. Nature Publishing Group
Nature

Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain 1–4. Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ec0922f019d862bd9bb29cccaa1865
https://doi.org/10.1038/s41586-022-05215-w

SupplementalTables from Mutations in the RAS/MAPK Pathway Drive Replication Repair–Deficient Hypermutated Tumors and Confer Sensitivity to MEK Inhibition

Autor: Uri Tabori, Cynthia E. Hawkins, Pamela S. Ohashi, Trevor J. Pugh, Adam Shlien, Michael D. Taylor, John M. Maris, David Malkin, Carol Durno, Melyssa Aronson, Daniel A. Morgenstern, Eric Bouffet, Gary Mason, David Samuel, Sangeetha N. Kalimuthu, Lazar Joksimovic, Michal Zapotocky, Matthew Zatzman, A. Sorana Morrissy, Liana Nobre, Nuno M. Nunes, Martin Komosa, Robert Siddaway, Sumedha Sudhaman, Melissa Edwards, Alexandra N. Riemenschneider, Simone C. Stone, Melissa A. Galati, Brittany B. Campbell

Table S1: Summary of likely pathogenic mutations detected in Foundation Medicine cohort of 1215 pediatric cancers. Table S2: Summary of RAS/MAPK pathway mutations and consequences detected in 48 RRD cancers.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1031a84e4fc1653137656aec9d2eb951
https://doi.org/10.1158/2159-8290.22540376