Spatially coordinated dynamic gene transcription in living pituitary tissue

Autor: Karen Featherstone, Kirsty Hey, Hiroshi Momiji, Anne V McNamara, Amanda L Patist, Joanna Woodburn, David G Spiller, Helen C Christian, Alan S McNeilly, John J Mullins, Bärbel F Finkenstädt, David A Rand, Michael RH White, Julian RE Davis

Publikováno v: eLife, Vol 5 (2016)

Transcription at individual genes in single cells is often pulsatile and stochastic. A key question emerges regarding how this behaviour contributes to tissue phenotype, but it has been a challenge to quantitatively analyse this in living cells over

Externí odkaz: https://doaj.org/article/4711de80f72b4aca95bc49e34466bac3

The local effects of ovarian diathermy in an ovine model of polycystic ovary syndrome.

Autor: Fiona Connolly, Michael T Rae, Mairead Butler, Alexander L Klibanov, Vassilis Sboros, Alan S McNeilly, W Colin Duncan

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e111280 (2014)

In order to develop a medical alternative to surgical ovarian diathermy (OD) in polycystic ovary syndrome (PCOS) more mechanistic information is required about OD. We therefore studied the cellular, molecular and vascular effects of diathermy on the

Externí odkaz: https://doaj.org/article/5551d1975b0a4a68996b58dc680046cc

Circadian clock mechanism driving mammalian photoperiodism

Autor: Helen C. Christian, Andrew S. I. Loudon, Matthew Hindle, Yasutaka Mizoro, Dave Burt, Ben Saer, Shona H. Wood, Judith McNeilly, Alan S. McNeilly, Yung Sung Cheng, Katarzyna Miedzinska, Simone Meddle, Nicola Begley

Publikováno v: Wood, S, Hindle, M, Mizoro, Y, Cheng, Y, Saer, B, Miedzinska-Bielecka, K, Christian, H, Begley, N, J, M, McNeilly, A, Meddle, S, Burt, D & Loudon, A 2020, ' Circadian clock mechanism driving mammalian photoperiodism. ', Nature Communications, vol. 11, 4291 (2020), pp. 1-15 . https://doi.org/10.1038/s41467-020-18061-z
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Wood, S, Hindle, M M, Mizoro, Y, Cheng, Y, Saer, B, Miedzinska, K, Christian, H C, Begley, N, McNeilly, J, McNeilly, A S, Meddle, S L, Burt, D W & Loudon, A 2020, ' Circadian clock mechanism driving mammalian photoperiodism ', Nature Communications, vol. 11, 4291 . https://doi.org/10.1038/s41467-020-18061-z

The annual photoperiod cycle provides the critical environmental cue synchronizing rhythms of life in seasonal habitats. In 1936, Bünning proposed a circadian-based coincidence timer for photoperiodic synchronization in plants. Formal studies suppor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe68ec4d59282f4ea3b26b1fb3be070
https://hdl.handle.net/20.500.11820/5e075f9c-9115-4113-8aa7-1d78e2ed165d

The in utero programming effect of increased maternal androgens and a direct fetal intervention on liver and metabolic function in adult sheep.

Autor: Kirsten Hogg, Charlotte Wood, Alan S McNeilly, W Colin Duncan

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24877 (2011)

Epigenetic changes in response to external stimuli are fast emerging as common underlying causes for the pre-disposition to adult disease. Prenatal androgenization is one such model that results in reproductive and metabolic features that are present

Externí odkaz: https://doaj.org/article/a497d4ab59ff47b5bf2a68e477119ae3

Gonadotrophic control of follicular development and function during the oestrous cycle of the ewe

Autor: A S McNeilly, D T Baird

Publikováno v: Bioscientifica Proceedings.

In the adult non-pregnant ewe the secretion of FSH is sufficient to ensure a continuous growth and development of antral follicles to 3-5 mm size at all times. Further development and increased secretion of oestradiol through the final 72 h to ovulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1fd56ba4a629cc8f98fe7008b660467d
https://doi.org/10.1530/biosciprocs.1.012