LONG-LASTING CONTROL OF HER-2 POSITIVE DISSEMINATED BREAST CANCER IN A REPRODUCTIVE AGED PATIENT

Autor: A. V. Vazhenin, N. V. Voroshina, O. S. Tereshin, N. S. Dubrovskaya

Publikováno v: Сибирский онкологический журнал, Vol 20, Iss 3, Pp 158-164 (2021)

Background. Breast cancer ranks as the second most common cancer (14.9 %) and the most common female cancer (20.9 %) in Russia. at the time of diagnosis, 11.0 % of patients have already developed metastases, and 10.3 % of patients die within the firs

Externí odkaz: https://doaj.org/article/4bca8c426d804812881dea6a8c99f216

4-Alkylsubstituted 3-Aryl-Cycl[3.2.2]Azine-1,2-Dicarboxylic Acids and Their Sodium Salts as Novel Π-Extended Blue-Green Fluorophores: Synthesis, Spectroscopy, Logd7.4 Distribution Coefficients and Cytotoxicity

Autor: Andrei S. Starikov, Mariya A. Lapshina, Pavel A. Tarakanov, Valery V. Kalashnikov, Elena S. Dubrovskaya, Sergey V. Simonov, Vladimir P. Kazachenko, Nadezhda N. Strakhova, Alexander V. Yarkov, Victor E. Pushkarev

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d792ffdd64e39c820991e493555bac31
https://doi.org/10.2139/ssrn.4219139

Stereospecific synthesis of tryptamine derivatives of alkaloid securinine and their potential neuroprotective activity

Autor: S. A. Pukhov, E. S. Dubrovskaya, S. G. Klochkov, Margarita E. Neganova

Publikováno v: AIP Conference Proceedings.

A series of stereospecific conjugates of the naturally occurring scaffold - alkaloid securinine 1 - was synthesized using the Lewis acid catalyst ytterbium triflate. The study of their antioxidant and cytoprotective properties showed that these compo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::185b1c998844f04a7ca38ba514153613
https://doi.org/10.1063/1.5087358

Molecular construction of multitarget neuroprotectors 4.* Synthesis and biological activity of conjugates of carbazoles and tetrahydrocarbazoles

Autor: E. S. Dubrovskaya, P. N. Shevtsov, L. G. Dubova, Elena F. Shevtsova, V. B. Sokolov, Sergey G. Klochkov, A. Yu. Aksinenko, Sergey O. Bachurin, T. A. Epishina, T. V. Goreva

Publikováno v: Russian Chemical Bulletin. 65:2306-2311

Unknown conjugates of carbazoles and tetrahydrocarbazoles were obtained by the alkylation of carbazoles and tetrahydrocarbazoles with 3,6-substituted 9-oxiranylmethylcarbazoles. The influence of synthesized 1-(9Н-carbazol-9-yl)-3-(1,2,3,4-tetrahydro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f84a7e2571f4115d0d752a867b927542
https://doi.org/10.1007/s11172-016-1582-x

Protective Effects of the Natural Sesquiterpene Lactones Against Damage Induced by Glutamate and Peroxide in SK-N-MC Cells

Autor: A. V. Semakov, Sergey G. Klochkov, E. S. Dubrovskaya, S. V. Afanasyeva, Margarita E. Neganova, V.I. Kozlovski

Publikováno v: Biomedical Chemistry: Research and Methods; Vol. 1 No. 3 (2018): Special Issue; e00051
Biomedical Chemistry: Research and Methods; Том 1 № 3 (2018): Специальный выпуск; e00051
Biomedical Chemistry: Research and Methods

An the present study we evaluated the effect of natural sesquiterpene lactones of plants of the genus Inula on the cells of neuroblastoma SK-N-MC under conditions of toxic stress induced by H2O2 and glutamate. Lactones increased cell survival under t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea9b2eb583fbc27ebc99acdcec8b47c
https://doi.org/10.18097/bmcrm00051