Zobrazeno 1 - 10
of 751
pro vyhledávání: '"A S, Wechsler"'
Publikováno v:
Oncology Reviews, Vol 18 (2024)
Chromosome Region Maintenance 1 (CRM1), also known as Exportin 1 (XPO1), is a protein that is critical for transport of proteins and RNA to the cytoplasm through the nuclear pore complex. CRM1 inhibition with small molecule inhibitors is currently be
Externí odkaz:
https://doaj.org/article/e5bc8c6adb384b8b8cc22dcfd2c8e2cc
Autor:
Erin M. Guest, John A. Kairalla, Meenakshi Devidas, Emily Hibbitts, Andrew J. Carroll, Nyla A. Heerema, Holly R. Kubaney, Margaret A. August, Sidharth Ramesh, Byunggil Yoo, Midhat S. Farooqi, Melinda G. Pauly, Daniel S. Wechsler, Rodney R. Miles, Joel M. Reid, Cynthia D. Kihei, Lia Gore, Elizabeth A. Raetz, Stephen P. Hunger, Mignon L. Loh, Patrick A. Brown
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Infants less than 1 year old diagnosed with KMT2A-rearranged (KMT2A-r) acute lymphoblastic leukemia (ALL) are at high risk of remission failure, relapse, and death due to leukemia, despite intensive therapies. Infant KMT2A-r ALL blasts are characteri
Externí odkaz:
https://doaj.org/article/b91198f427bc4dd39ad94aff06c2ddf3
Autor:
Hope L. Mumme, Sunil S. Raikar, Swati S. Bhasin, Beena E. Thomas, Taylor Lawrence, Elizabeth P. Weinzierl, Yakun Pang, Deborah DeRyckere, Chuck Gawad, Daniel S. Wechsler, Christopher C. Porter, Sharon M. Castellino, Douglas K. Graham, Manoj Bhasin
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-25 (2023)
Abstract Background Mixed phenotype acute leukemia (MPAL), a rare subgroup of leukemia characterized by blast cells with myeloid and lymphoid lineage features, is difficult to diagnose and treat. A better characterization of MPAL is essential to unde
Externí odkaz:
https://doaj.org/article/27b0d44d90b644919eac2539e49cde72
Autor:
Hope Mumme, Beena E. Thomas, Swati S. Bhasin, Upaasana Krishnan, Bhakti Dwivedi, Pruthvi Perumalla, Debasree Sarkar, Gulay B. Ulukaya, Himalee S. Sabnis, Sunita I. Park, Deborah DeRyckere, Sunil S. Raikar, Melinda Pauly, Ryan J. Summers, Sharon M. Castellino, Daniel S. Wechsler, Christopher C. Porter, Douglas K. Graham, Manoj Bhasin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Acute myeloid leukemia (AML) microenvironment exhibits cellular and molecular differences among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to analyze pediatric AML bone marrow (BM) samples from diagnosis (Dx),
Externí odkaz:
https://doaj.org/article/a3787863b5cb43ff9dcb50ae8a436b4d
Autor:
Catherine P Lavau, Waitman K Aumann, Sei-Gyung K Sze, Veerain Gupta, Katelyn Ripple, Sarah A Port, Ralph H Kehlenbach, Daniel S Wechsler
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0232036 (2020)
The NUP98 and NUP214 nucleoporins (NUPs) are recurrently fused to heterologous proteins in leukemia. The resulting chimeric oncoproteins retain the phenylalanine-glycine (FG) repeat motifs of the NUP moiety that mediate interaction with the nuclear e
Externí odkaz:
https://doaj.org/article/e20feed315bf4dd9b9465d7ea188da83
Publikováno v:
Case Reports in Pediatrics, Vol 2020 (2020)
Parvovirus B19 infection in pediatrics most commonly causes fifth disease, a mild viral illness. Hematologic manifestations include severe anemia, especially in patients with chronic hemolytic anemias or who are immunocompromised. Because of the shor
Externí odkaz:
https://doaj.org/article/39ed2db28ebe46419fe494bb90cfacba
Autor:
Kristin Schroeder, Anthony Saxton, Jessica McDade, Christina Chao, Nestory Masalu, Colin Chao, Daniel S. Wechsler, Beda Likonda, Nelson Chao
Publikováno v:
Journal of Global Oncology, Vol 4, Pp 1-10 (2017)
Purpose: The majority of new diagnoses of pediatric cancer are made in resource-poor countries, where survival rates range from 5% to 25% compared with 80% in high-resource countries. Multiple factors, including diagnostic and treatment capacities an
Externí odkaz:
https://doaj.org/article/7b45dd3e71794d569324ca9f0057576d
Autor:
Paulo Sérgio dos Santos Teixeira, Ana Silvia A.M.T. Moura, Francisco S. Wechsler, Simone Fernandes, Vânia G.M. Mattaraia
Publikováno v:
World Rabbit Science, Vol 25, Iss 2, Pp 147-158 (2017)
The objective was to evaluate the effect of the interaction of diet density in the rearing phase×diet density in the reproductive phase on carcass composition, pregnancy rate, and litter performance of primiparous rabbit does. The experiment followe
Externí odkaz:
https://doaj.org/article/09a2136da9234c19ae00030c15c1e8b9
Autor:
Kimberly Stegmaier, Jérôme Tamburini, Anthony Letai, Mark Wunderlich, Lynn H. Lee, Federica Piccioni, Scott T. Younger, Joseph D. Mancias, Jeremy A. Ryan, Biniam Adane, Sarah Mouche, Thelma Mashaka, Amy Saur Conway, Amanda L. Robichaud, Guillaume Kugener, Caroline S. Wechsler, Miljan Kuljanin, Neekesh V. Dharia, Bo Kyung A. Seong, Nastassja K. Scheidegger, Clément Larrue, Shan Lin
Supplementary Tables from An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a00231f66c2f1f2d618c874e239af4
https://doi.org/10.1158/2159-8290.22540225.v1
https://doi.org/10.1158/2159-8290.22540225.v1
Autor:
Kimberly Stegmaier, Jérôme Tamburini, Anthony Letai, Mark Wunderlich, Lynn H. Lee, Federica Piccioni, Scott T. Younger, Joseph D. Mancias, Jeremy A. Ryan, Biniam Adane, Sarah Mouche, Thelma Mashaka, Amy Saur Conway, Amanda L. Robichaud, Guillaume Kugener, Caroline S. Wechsler, Miljan Kuljanin, Neekesh V. Dharia, Bo Kyung A. Seong, Nastassja K. Scheidegger, Clément Larrue, Shan Lin
CRISPR–Cas9-based genetic screens have successfully identified cell type–dependent liabilities in cancer, including acute myeloid leukemia (AML), a devastating hematologic malignancy with poor overall survival. Because most of these screens have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8b74c36b48f4b32ecfaef81a5921cb
https://doi.org/10.1158/2159-8290.c.6549322
https://doi.org/10.1158/2159-8290.c.6549322