Zobrazeno 1 - 10
of 384
pro vyhledávání: '"A S, SCHLESINGER"'
Autor:
Angélica M. Olmo-Fontánez, Anna Allué-Guardia, Andreu Garcia-Vilanova, Jeremy Glenn, Shu-Hua Wang, Robert E. Merritt, Larry S. Schlesinger, Joanne Turner, Yufeng Wang, Jordi B. Torrelles
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 12 (2024)
ABSTRACT Tuberculosis is one of the leading causes of death due to a single infectious agent. Upon infection, Mycobacterium tuberculosis (M.tb) is deposited in the alveoli and encounters the lung mucosa or alveolar lining fluid (ALF). We previously s
Externí odkaz:
https://doaj.org/article/d9dc8dd0667840c8b32cd41e3681410b
Autor:
Dharti Shantaram, Rebecca Hoyd, Alecia M. Blaszczak, Linda Antwi, Anahita Jalilvand, Valerie P. Wright, Joey Liu, Alan J. Smith, David Bradley, William Lafuse, YunZhou Liu, Nyelia F. Williams, Owen Snyder, Caroline Wheeler, Bradley Needleman, Stacy Brethauer, Sabrena Noria, David Renton, Kyle A. Perry, Prabha Nagareddy, Daniel Wozniak, Sahil Mahajan, Pranav S. J. B. Rana, Maciej Pietrzak, Larry S. Schlesinger, Daniel J. Spakowicz, Willa A. Hsueh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Neutrophils are increasingly implicated in chronic inflammation and metabolic disorders. Here, we show that visceral adipose tissue (VAT) from individuals with obesity contains more neutrophils than in those without obesity and is associated
Externí odkaz:
https://doaj.org/article/9193f2df0d714844a1ba35b032ffb441
Autor:
Susanta Pahari, Anna-Lena Neehus, Bruce C. Trapnell, Jacinta Bustamante, Jean-Laurent Casanova, Larry S. Schlesinger
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103061- (2024)
Summary: Human alveolar macrophages are a unique myeloid subset critical for understanding pulmonary diseases and are difficult to access. Here, we present a protocol to generate human alveolar macrophage-like (AML) cells from fresh peripheral blood
Externí odkaz:
https://doaj.org/article/9e6939bd85664fe98a0a6be76a6eb049
Autor:
Susanta Pahari, Eusondia Arnett, Jan Simper, Abul Azad, Israel Guerrero-Arguero, Chengjin Ye, Hao Zhang, Hong Cai, Yufeng Wang, Zhao Lai, Natalie Jarvis, Miranda Lumbreras, Diego Jose Maselli, Jay Peters, Jordi B. Torrelles, Luis Martinez-Sobrido, Larry S. Schlesinger
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Alveolar macrophages (AMs) are unique lung resident cells that contact airborne pathogens and environmental particulates. The contribution of human AMs (HAMs) to pulmonary diseases remains poorly understood due to the difficulty in accessing
Externí odkaz:
https://doaj.org/article/1606ea0b7b6449dabb3bd799cf4140d6
Autor:
Dhiraj K. Singh, Ekaterina Aladyeva, Shibali Das, Bindu Singh, Ekaterina Esaulova, Amanda Swain, Mushtaq Ahmed, Journey Cole, Chivonne Moodley, Smriti Mehra, Larry S. Schlesinger, Maxim N. Artyomov, Shabaana A. Khader, Deepak Kaushal
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
To gain insights into the early immune dynamics of transcriptional changes during SARS-CoV-2 infection, Singh et al. provide longitudinal scRNA-Seq of the broncho-alveolar compartment of SARS-CoV-2 infected rhesus macaques. They observe an accumulati
Externí odkaz:
https://doaj.org/article/ae41ab4ead8645a8baa2d47cebcd2017
Autor:
Chrissy M Leopold Wager, Jordan R Bonifacio, Jan Simper, Adrian A Naoun, Eusondia Arnett, Larry S Schlesinger
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1011297 (2023)
Macrophages are a first line of defense against pathogens. However, certain invading microbes modify macrophage responses to promote their own survival and growth. Mycobacterium tuberculosis (M.tb) is a human-adapted intracellular pathogen that explo
Externí odkaz:
https://doaj.org/article/86c951c3530c4adb9cc0e3e348070ab8
Autor:
Julia M. Scordo, Génesis P. Aguillón-Durán, Doris Ayala, Ana Paulina Quirino-Cerrillo, Eminé Rodríguez-Reyna, Mateo Joya-Ayala, Francisco Mora-Guzmán, Eder Ledezma-Campos, Alejandro Villafañez, Larry S. Schlesinger, Jordi B. Torrelles, Joanne Turner, Blanca I. Restrepo
Publikováno v:
International Journal of Infectious Diseases, Vol 111, Iss , Pp 85-91 (2021)
SUMMARY: Background: Interferon gamma release assays (IGRAs) are used to detect latent Mycobacterium tuberculosis (M.tb) infection (LTBI) in adults, but their performance in older people is not well-established. We evaluated IGRAs for LTBI detection
Externí odkaz:
https://doaj.org/article/3c1e94b709d849ecb245a7b41d34d7f6
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The risk of active tuberculosis disease is 15-21 times higher in those coinfected with human immunodeficiency virus-1 (HIV) compared to tuberculosis alone, and tuberculosis is the leading cause of death in HIV+ individuals. Mechanisms driving synergy
Externí odkaz:
https://doaj.org/article/91f0d61f6b0643eda98e796045ae7fca
Autor:
Riti Sharan, Shashank R. Ganatra, Dhiraj K. Singh, Journey Cole, Taylor W. Foreman, Rajesh Thippeshappa, Charles A. Peloquin, Vinay Shivanna, Olga Gonzalez, Cheryl L. Day, Neel R. Gandhi, Edward J. Dick Jr., Shannan Hall-Ursone, Smriti Mehra, Larry S. Schlesinger, Jyothi Rengarajan, Deepak Kaushal
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
A once-weekly oral dose of isoniazid and rifapentine for 3 months (3HP) is recommended by the CDC for treatment of latent tuberculosis infection (LTBI). The aim of this study is to assess 3HP-mediated clearance of M. tuberculosis bacteria in macaques
Externí odkaz:
https://doaj.org/article/659732e8266a421b8e6775d23db444b0
Autor:
Bruce A. Rosa, Mushtaq Ahmed, Dhiraj K. Singh, José Alberto Choreño-Parra, Journey Cole, Luis Armando Jiménez-Álvarez, Tatiana Sofía Rodríguez-Reyna, Bindu Singh, Olga Gonzalez, Ricardo Carrion, Larry S. Schlesinger, John Martin, Joaquín Zúñiga, Makedonka Mitreva, Deepak Kaushal, Shabaana A. Khader
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Rosa et al. find that genes associated with Interferon (IFN) signaling, neutrophil degranulation and innate immune pathways are induced in the lungs of macaques in response to SARS-CoV-2 infection, whereas genes associated with collagen formation and
Externí odkaz:
https://doaj.org/article/fee1d848484c4499aa50fa45ecb7d32f