Chronic high-sugar diet in adulthood protects Caenorhabditis elegans from 6-OHDA-induced dopaminergic neurodegeneration

Autor: Katherine S. Morton, Jessica H. Hartman, Nathan Heffernan, Ian T. Ryde, Isabel W. Kenny-Ganzert, Lingfeng Meng, David R. Sherwood, Joel N. Meyer

Publikováno v: BMC Biology, Vol 21, Iss 1, Pp 1-19 (2023)

Abstract Background Diets high in saturated fat and sugar, termed “Western diets,” have been associated with several negative health outcomes, including increased risk for neurodegenerative disease. Parkinson’s disease (PD) is the second most p

Externí odkaz: https://doaj.org/article/874606a651f54ef29a0f753f990c4cef

The effect of common paralytic agents used for fluorescence imaging on redox tone and ATP levels in Caenorhabditis elegans.

Autor: Katherine S Morton, Ashlyn K Wahl, Joel N Meyer

Publikováno v: PLoS ONE, Vol 19, Iss 4, p e0292415 (2024)

One aspect of Caenorhabditis elegans that makes it a highly valuable model organism is the ease of use of in vivo genetic reporters, facilitated by its transparent cuticle and highly tractable genetics. Despite the rapid advancement of these technolo

Externí odkaz: https://doaj.org/article/941efe1400474c5da54aefc1951f03c6

Experimental testing of a prototype cantilevered liquid-nitrogen-cooled silicon mirror

Autor: G. Cutler, D. Cocco, B. Bentley, M. Cervantes, P. Chavez, J. Chrzan, S. DiMaggio, R. Hussey, J. Ilmberger, J. Lindsay, E. Lizotte, K. McCombs, S. Morton, G. Paulovits, K. Pearson, C. Redding, N. Smith, K. Tokunaga, D. Zehm, E. DiMasi, H. Padmore

Publikováno v: Journal of Synchrotron Radiation, Vol 30, Iss 1, Pp 76-83 (2023)

This report presents testing of a prototype cantilevered liquid-nitrogen-cooled silicon mirror. This mirror was designed to be the first mirror for the new soft X-ray beamlines to be built as part of the Advanced Light Source Upgrade. Test activities

Externí odkaz: https://doaj.org/article/2fa1ea927de344b787e03bdbdfa87494

JET machine operations in T&D-T

Autor: The JET Operations Team (presented by D.B. King), E. Abdelrahman, A. Abdul Hamid, N. Abid, K. Abraham, O. Adabonyan, C. Adlam, M. Afzal, M. Akhtar, V. Aldred, S. Aldworth, S. Aleiferis, M. Ali, R. Alie, R. Allan, H. Allen, E. Alli, M. Allinson, P. Almond, J. Angus, K. Antcliffe, I. Antoniou, L. Appel, C. Appelbee, C. Aramunde, N. Archer, S. Aria, H. Arkuszynski, M. Arshad, G. Artaserse, A. Ash, C. Ashe, T. Aue, D. Auld, B. Austin, Y. Austin, C. Ayres, R.B. Morales, S. Baker, S. Bakes, I. Balboa, C. Balshaw, N. Balshaw, J. Banks, J. Banner, A. Barnard, M. Barnard, M. Baruzzo, C. Basagiannis, S. Bathe Hariyanandan, P. Batistoni, R. Baughan, P. Beaumont, D. Beckett, A. Begolli, M. Beldishevski, K. Bell, E. Belonohy, J. Bentley, J. Bernardo, M. Berry, J. Bhatt, S. Bickerton, J. Bielecki, W. Bird, D. Blackett, K. Blackman, S. Blake, P. Blatchford, A. Bleasdale, A. Boboc, J. Booth, P. Boulting, M. Bowden, C. Boyd, K. Boyd, R. Bracey, D. Brennan, A. Brett, M. Bright, M. Brix, I. Brooks, B. Brown, P. Brown, M. Brown, P. Brummitt, B. Viola, A. Buckingham, M. Buckley, J. Bumpass, M. Burford, A. Burgess, J. Burton-Sweeten, A. Busse, D. Butcher, P. Cahill, P. Camp, I. Campbell, R. Canavan, J. Cane, M. Cannon, N. Canterbury, A. Carberry, P. Card, M. Carlick, M. Carlo, P. Carman, A. Carruthers, S. Carter, I.S. Carvalho, P. Carvalho, F. Casson, D. Chalk, B. Chamberlain, P. Chauhan, A. Chow, A. Churchman, D. Ciric, M. Clark, J. Clarkson, R. Clarkson, T. Clayton, M. Cleverly, P. Coates, I. Coffey, J. Collins, S. Conroy, N.J. Conway, R. Conway, J. Cook, M. Cooke, D. Coombs, P. Cooper, S. Cooper, G. Corrigan, R. Cotterell, A. Coulson, M. Cox, S. Cox, S. Cramp, D. Craven, R. Craven, M. Crick, D. Croft, T. Cronin, Z. Cui, A. Cullen, R. Cumming, C. Cummings, A. Dal Molin, P. Dalgliesh, S. Dalley, A. Danquah, S. Davies, G. Davis, H. Dawson, K. Dawson, S. Dawson, I. Day, L. de Caires, E. de la Luna, K. Deakin, J. Deane, M. Dearing, A. Dennett, T. Dickson, J. Dobrashian, T. Dochnal, S. Dorling, D. Douai, S. Dowson, J. Drewitt, G. Drummond, P. Dumortier, R. Eade, R. Eastham, K. Eden, J. Edmond, J. Edwards, P. Edwards, H. Elamin, S. Elford, H. El-Haroun, P. Ellis, C. Elsmore, S. Emery, G. Evans, S. Evans, D. Fagan, T. Farmer, I. Farquhar, R. Felton, F. Ferner, J. Fessey, P. Finburg, G. Fishpool, L. Fittill, J. Flanagan, K. Flinders, S. Foley, M. Fontana, M. Fortune, J. Foster, C. Fowler, P. Fox, O. Franklin, R. Franklin, R. Fraser, S. French, M. Furseman, A. Gabbidon, L. Garcia, J. Garcia, M. Gardener, D. Gear, T. Gedling, S. Gee, P. Gell, R. George, S. Gerasimov, M. Gethins, Z. Ghani, L. Giacomelli, C. Gibson, V. Gilsenan, C. Giroud, R. Glen, J. Goff, C. Goodman, A. Goodyear, A. Gordon, S. Gore, S. Gosden, N. Gotts, E. Gow, W. Graham, G. Graham, M. Green, R. Gregory, R. Griffiths, T. Griffiths, F. Griph, C. Grundy, T. Grundy, D. Guard, D. Guest, C. Gurl, S. Hacquin, A. Hakola, K. Hammond, H. Harmer, P. Harper, S. Harris, D. Hart, D. Hattan, A. Haupt, J. Hawes, N. Hawkes, J. Hawkins, P. Hawkins, S. Hayes, S. Hazael, D. Heads, P. Heesterman, O. Hemming, R.B. Henriques, G. Hermon, G. Hewson, T. Hibberd, M. Hill, J. Hillesheim, I. Hirb, K. Ho, C. Hogben, A. Hollingsworth, S. Hollis, M. Hook, D. Hopley, N. Horsten, A. Horton, L.D. Horton, L. Horvath, S. Hotchin, Z. Huang, E. Hubenov, V. Huber, A. Huber, C. Huddart, T. Huddleston, T. Hunter, Y. Husain, A. Hynes, J. Ingleby, S. Ives, E. Ivings, S. Jackson, T. Jackson, P. Jacquet, N. Jayasekera, I. Jepu, D. Jezzard, E. Joffrin, R. Johnson, J. Johnston, C. Jones, E. Jones, G. Jones, L. Jones, S. Jones, T. Jones, M. Jones, A. Joyce, M. Juvonen, A. Kantor, A. Kappatou, G. Karajgikar, J. Karhunen, I. Karnowska-Paterski, E. Karsakos, G. Kaveney, G. Kay, D. Keeling, T. Keenan, R. Kelly, W. Kelly, D. Kennedy, R. Kennedy, O. Kent, K. Khan, D. King, D. Kinna, V. Kiptily, K. Kirov, G. Kneale, M. Knight, P. Knight, J. Knipe, R. Knipe, S. Knipe, P. Kochanski, D. Kos, M. Kovari, E. Kowalska-Strzęciwilk, N. Kraus, M. Kresina, B. Labit, A. Laing, V. Laksharam, N. Lam, B. Lane, C. Lane, T. Lavender, A. Lawson, K. Lawson, G. Learoyd, T. Leeson, X. Lefebvre, J. Lehmann, M. Lennholm, K. Lennon, E. Lerche, S. Lesnoj, E. Letellier, L. Lewin, J. Lewis, J. Li, G. Liddiard, E. Litherland-Smith, F. Liu, R. Lobel, J. Logan, P. Lomas, C. Long, U. Losada, C. Loveridge, T. Lowe, C. Lowry, R. Lucock, G. Lyons, J. Macdonald, P. Macheta, T. Madden, J. Maddock, C.F. Maggi, J. Mailloux, A. Manning, C. Manning, N. Mantel, A. Manzanares, S. Marsden, J. Marsh, R. Marshall, A. Martin, M. Maslov, G. Matthews, N. Mayfield, M. Mayoral, R. McAdams, L. McCafferty, P. McCullen, D. McDonald, A. McDonnell, D. McGuckin, T. McIver, V. McKay, R. McKean, L. McNamee, A. McShee, R. Meadows, D. Mederick, M. Medland, K. Meghani, A. Meigs, S. Menmuir, I. Merrigan, S. Mianowski, P. Middleton, C. Miles, J. Milnes, A. Milocco, J. Mitchell, P. Mitchell, P. Monaghan, I. Monakhov, P. Moody, R. Mooney, C. Moore, N. Mooring, L. Morgan, R. Morgan, J. Morris, O. Morton, S. Morton, P. Mulvana, S. Munot, R. Munro-Smith, K. Musgrave, R. Naish, N. Neethiraj, J. Neilson, A. Newman, S. Ng, M. Nicassio, K. Nicholls, M. Nightingale, C. Noble, R. Normington, C. Nygaard, J. O’Callaghan, R. Olney, B. O’Meara, M. O’Mullane, C. O’Neill, C. Opara, K. O’Rourke, J. Ottley, K. Otu, A. Owen, N. Pace, K. Palamartchouk, D. Paley, J. Palgrave, G. Papadopoulos, V. Parail, A. Parrott, A. Parsloe, L. Parsons, R. Parsons, A. Patel, J. Patel, A. Peacock, M. Pearce, T. Pearce, I. Pearson, J. Penzo, A. Perdas, T. Pereira, C. Perez Von Thun, D. Perry, N. Petrella, M. Peyman, N. Platt, M. Poradzinski, M. Porter, M. Porton, C. Powell, J. Pozzi, M. Price, L. Price, P. Puglia, D. Pulley, K. Purahoo, M. Rainford, A. Raj, S. Randhawa, S. Rapa, K. Ravisankar, C. Rayner, A. Read, C. Reux, S. Reynolds, V. Riccardo, L. Richiusa, D. Rigamonti, F. Rimini, J. Roberts, R. Robins, S. Robinson, T. Robinson, D. Robson, S. Romanelli, F. Rose, C. Rose-Innes, D. Rouse, S. Rowe, N. Rowland, D. Rowlands, M. Rubel, K. Sabin, R. Salmon, H. Salter, A. Sanders, E. Sanders, I. Sanders, D. Sandiford, F. Sanni, R. Sarwar, R. Sayles, C. Scaysbrook, G. Scott, D. Scraggs, S. Scully, R. Sealey, E. Searle, M. Segato, M. Sertoli, C. Shanks, R. Sharma, A. Shaw, K. Sheahan, H. Sheikh, D. Shrestha, R. Siddiqui, S. Silburn, J. Silva, D. Simfukwe, J. Simpson, M. Sinclair, A. Sips, P. Sirén, S. Skeats, N. Skinner, B. Slade, J. Slater, T. Smart, G. Smith, J. Smith, N. Smith, P. Smith, T. Smith, F. P. Smith, J. Snell, K. Snelling, K. Soare, E. Solano, A. Spelzini, C. Srinivasan, Z. Stancar, P.A. Staniec, M. Stead, R. Steadman, L. Steel, D. Steele, A. Stephen, J. Stephens, L. Stevenson, P. Stevenson, C. Steventon, L. Sticklen, M. Stojanov, S. Strikwerda, C. Stuart, G. Stubbs, N. Studd, W. Studholme, H. Sun, S. Surendran, G. Szepesi, M. Szoke, H. Tan, A. Taylor, D. Taylor, K. Taylor, A. Thingore, B. Thomas, J. Thomas, A. Thorman, A. Tilley, A. Tipton, N. Tipton, H. Todd, P. Tonner, A. Tookey, M. Towndrow, M. Tsang, E. Tsitrone, I. Turner, M. Turner, G. Tvalashvili, S. Tyrrell, A. Vadgama, D. Valcarcel, Q. Van Der Westhuizen, J. Verdon, N. Vianello, A. Vittal, Z. Vizvary, B. Wakeling, M. Walker, R. Walker, T. Wall, M. Walsh, T. Walsh, J. Walters, J. Walton, R. Walton, S. Warder, F. Warren, R. Warren, J. Waterhouse, T. Webster, G. Wells, C. Wellstood, A. West, M. Wheatley, S. Whiffin, A. Whitehead, C. Whitehead, D. Whittaker, A. Widdowson, J. Wilcox, D. Wilkins, R. Wilkins, J. Williams, M. Williams, D. Willoughby, A. Wilson, I. Wilson, T. Wilson, M. Wischmeier, P. Wise, G. Withenshaw, A. Withycombe, D. Witts, J. Witts, R. Wood, L. Woodham, C. Woodley, J. Woodley, R. Woodley, B. Woods, S. Wray, T. Xu, I. Young, R. Young, K-D. Zastrow, Y. Zayachuk, M. Zerbini

Publikováno v: Nuclear Fusion, Vol 64, Iss 10, p 106014 (2024)

JET, the world’s largest operating tokamak with unique Be/W wall and tritium handling capability, completed a Deuterium-Tritium (D-T) campaign in 2021 (Maggi et al 29th Fusion Energy Conf. ) following a decade of preparatory experiments, dedicated

Externí odkaz: https://doaj.org/article/cdccaad611b94a43b0001f6c57d33c2a

Higher burden of cardiometabolic and socioeconomic risk factors in women with type 2 diabetes: an analysis of the Glycemic Reduction Approaches in Diabetes (GRADE) baseline cohort

Autor: C Wright, C Sanders, C Wilson, L Tucker, S Jones, S Douglass, C Patel, A Kumar, S Smith, A Ghosh, C Adams, R Hill, D Martin, J Hu, M Lee, N Patel, O Smith, J Cook, J Day, M Jackson, G Riera, P McGee, J Park, J Jiménez, S Yang, A Carlson, C Martin, H Liu, Y Li, A Krol, K Wright, S Golden, A Sood, J Martinez, D Sanchez, K Burton, Y Gao, S Martin, O Sanchez, C DeSouza, M Johnson, L Estrada, A Jackson, J Higgins, K Martin, J Craig, A Kuhn, L Ngo, Deborah J Wexler, R Chatterjee, E Walker, J Kerr, W Taylor, J Lim, M Perez, R Henry, Vanita R Aroda, R Fraser, Cyrus Desouza, E King, C Campbell, J González, E Diaz, P Zhang, J Marks, S Abraham, A Ross, M Khalid, T Young, J Myers, J Barzilay, B Chambers, G Montes, C Jensen, J McConnell, R Nelson, L Prosser, S Morton, M Curtis, P Wilson, L Young, M Fürst, S Warren, C Newman, S Kuo, N Rasouli, A Werner, L Morton, A Ghazi, M Salam, F Ismail-Beigi, P Kringas, C Baker, E Ellis, A Cherian, L Holloway, M Madden, B Hollis, G Fuller, B Steiner, K Stokes, R Ayala, T Lowe, K Chu, S Durán, D Dyer, A Alfred, J Leger, Nicole M Butera, T Hamilton, J Costello, E Burgess, R Garg, A Maxwell, C Stevens, W Ye, T Tran, L Fischer, M Hurtado, H Schneier, C Lund, R Lorch, M Mullen, J Bantle, K Arnold, D Wexler, A TURCHIN, MS Lee, D Howard, J Tejada, S Hernandez, Tasma Harindhanavudhi, E Schroeder, K Pham, S Kunkel, A Fagan, G Lord, H CHONG, A Smiley, E Debnam, H Petrovitch, M Bäckman, B Kauffman, V Jenkins, B Cramer, JP Crandall, MD McKee, S Behringer-Massera, J Brown-Friday, E Xhori, K Ballentine-Cargill, H Estrella, S Gonzalez de la torre, J Lukin, LS Phillips, D Olson, M Rhee, TS Raines, J Boers, C Gullett, M Maher-Albertelli, R Mungara, L Savoye, CA White, F Morehead, S Person, M Sibymon, S Tanukonda, A Balasubramanyam, R Gaba, P Hollander, E Roe, P Burt, K Chionh, C Falck-Ytter, L Sayyed Kassem, M Tiktin, T Kulow, KA Stancil, J Iacoboni, MV Kononets, L Colosimo, R Goland, J Pring, L Alfano, C Hausheer, K Gumpel, A Kirpitch, JB Green, H AbouAssi, MN Feinglos, J English Jones, RP Zimmer, BM Satterwhite, K Evans Kreider, CR Thacker, CN Mariash, KJ Mather, A Lteif, V Pirics, D Aguillar, S Hurt, R Bergenstal, T Martens, J Hyatt, H Willis, W Konerza, K Kleeberger, R Passi, S Fortmann, M Herson, K Mularski, H Glauber, J Prihoda, B Ash, C Carlson, PA Ramey, E Schield, B Torgrimson-Ojerio, E Panos, S Sahnow, K Bays, K Berame, D Ghioni, J Gluth, K Schell, J Criscola, C Friason, S Nazarov, N Rassouli, R Puttnam, B Ojoawo, C Sanders-Jones, Z El-Haqq, A Kolli, J Meigs, A Dushkin, G Rocchio, M Yepes, H Dulin, M Cayford, A DeManbey, M Hillard, N Thangthaeng, L Gurry, R Kochis, E Raymond, V Ripley, V Aroda, A Loveland, M Hamm, HJ Florez, WM Valencia, S Casula, L Oropesa-Gonzalez, L Hue, AK Riccio Veliz, R Nieto-Martinez, M Gutt, A Ahmann, D Aby-Daniel, F Joarder, V Morimoto, C Sprague, D Yamashita, N Cady, N Rivera-Eschright, P Kirchhoff, B Morales Gomez, J Adducci, A Goncharova, SH Hox, M Matwichyna, NO Bermudez, L Broadwater, RR Ishii, DS Hsia, WT Cefalu, FL Greenway, C Waguespack, N Haynes, A Thomassie, B Bourgeois, C Hazlett, S Mudaliar, S Boeder, J Pettus, D Garcia-Acosta, S Maggs, C DeLue, E Castro, J Krakoff, JM Curtis, T Killean, E Joshevama, K Tsingine, T Karshner, J Albu, FX Pi-Sunyer, S Frances, C Maggio, J Bastawrose, X Gong, MA Banerji, D Lorber, NM Brown, DH Josephson, LL Thomas, M Tsovian, MH Jacobson, MM Mishko, MS Kirkman, JB Buse, J Dostou, K Bergamo, A Goley, JF Largay, S Guarda, J Cuffee, D Culmer, H Almeida, S Coffer, L Kiker, K Josey, WT Garvey, A Agne, S McCullars, RM Cohen, MC Rogge, K Kersey, S Lipp, MB Vonder Meulen, C Underkofler, S Steiner, E Cline, WH Herman, R Pop-Busui, MH Tan, A Waltje, A Katona, L Goodhall, R Eggleston, K Whitley, S Bule, N Kessler, E LaSalle, ER Seaquist, A Bantle, T Harindhanavudhi, B Redmon, M Coe, M Mech, A Taddese, L Lesne, L Kuechenmeister, V Shivaswamy, AL Morales, K Seipel, J Eggert, R Tillson, DS Schade, A Adolphe, M Burge, E Duran-Valdez, P August, MG Rodriguez, O Griffith, A Naik, Barbara I Gulanski, Heidi Krause-Steinrauf, Judith H Lichtman, Jennifer B Green, Colleen E Suratt, Hiba AbouAssi, Andrew J Ahmann, E Gonzalez Hattery, A Ideozu, G McPhee, SA Khan, JB Kimpel, HM Ismail, ME Larkin, M Magee, A Ressing, L Manandhar, F Mwicigi, V Lagari-Libhaber, A Cuadot, YJ Kendal, B Veciana, G Fry, A Dragg, B Gildersleeve, J Arceneaux, M Pavlionis, A Stallings, S Machineni, AL Cherrington, MCR Lawson, C Adkins, T Onadeko, M Razzaghi, C Lyon, R Penaloza, WI Sivitz, LK Knosp, S Bojescu, S Burbach, A Bancroft, FA Jamaleddin Ahmad, D Hernandez McGinnis, B Pucchetti, E Scripsick, A Zamorano, RA DeFronzo, E Cersosimo, M Abdul-Ghani, C Triplitt, D Juarez, RI Garza, H Verastiqui, C Puckett, P Raskin, C Rhee, LF Jordan, S Sao, L Osornio Walker, L Schnurr-Breen, RB Kreymer, D Sturgess, KM Utzschneider, SE Kahn, L Alarcon-Casas Wright, EJ Boyko, EC Tsai, DL Trence, S Trikudanathan, BN Fattaleh, BK Montgomery, KM Atkinson, A Kozedub, T Concepcion, C Moak, N Prikhodko, S Rhothisen, TA Elasy, L Shackelford, R Goidel, N Hinkle, C Lovell, J Lipps Hogan, JB McGill, T Schweiger, S Kissel, C Recklein, MJ Clifton, W Tamborlane, A Camp, B Gulanski, SE Inzucchi, M Alguard, P Gatcomb, K Lessard, L Iannone, A Montosa, E Magenheimer, J Fradkin, HB Burch, AA Bremer, DM Nathan, JM Lachin, H Krause-Steinrauf, N Younes, I Bebu, N Butera, CJ Buys, MR Gramzinski, SD Hall, E Kazemi, E Legowski, C Suratt, M Tripputi, A Arey, J Bethepu, P Mangat Dhaliwal, E Mesimer, M Steffes, J Seegmiller, A Saenger, V Arends, D Gabrielson, T Conner, J Huminik, A Scrymgeour, EZ Soliman, Y Pokharel, ZM Zhang, L Keasler, S Hensley, R Mihalcea, DJ Min, V Perez-Rosas, K Resnicow, H Shao, J Luchsinger, S Assuras, E Groessl, F Sakha, N Hillery, BM Everett, I Abdouch, G Bahtiyar, P Brantley, FE Broyles, G Canaris, P Copeland, JJ Craine, WL Fein, A Gliwa, L Hope, R Meiners, V Meiners, H O’Neal, JE Park, A Sacerdote, E Sledge, L Soni, J Steppel-Reznik, B Brooks-Worrell, CS Hampe, JP Palmer, A Shojaie, L Doner Lotenberg, JM Gallivan, DM Tuncer

Publikováno v: BMJ Open Diabetes Research & Care, Vol 11, Iss 2 (2023)

Introduction Type 2 diabetes mellitus (T2DM) is a powerful risk factor for cardiovascular disease (CVD), conferring a greater relative risk in women than men. We sought to examine sex differences in cardiometabolic risk factors and management in the

Externí odkaz: https://doaj.org/article/c3d468413b944f31987d101f23f3970f