Zobrazeno 1 - 10
of 107
pro vyhledávání: '"A S, Janoff"'
Autor:
Arthur C. Louie, Andrew S. Janoff, Christine E. Swenson, Lawrence D. Mayer, Stephen K.L. Chia, Wilson H. Miller, Kim N. Chi, Karen A. Gelmon, Gerald Batist
Supplementary Data from Safety, Pharmacokinetics, and Efficacy of CPX-1 Liposome Injection in Patients with Advanced Solid Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a7b50adbb285907a5434afd58b6d58a
https://doi.org/10.1158/1078-0432.22440048.v1
https://doi.org/10.1158/1078-0432.22440048.v1
Autor:
Arthur C. Louie, Andrew S. Janoff, Christine E. Swenson, Lawrence D. Mayer, Stephen K.L. Chia, Wilson H. Miller, Kim N. Chi, Karen A. Gelmon, Gerald Batist
Purpose: CPX-1 is a novel, liposome-encapsulated formulation of irinotecan and floxuridine designed to prolong in vitro optimized synergistic molar ratios of both drugs postinfusion. This open-label, single-arm, dose-escalating phase I study was desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36db2a19fd23f88a2e9ead6ed1ec7c8e
https://doi.org/10.1158/1078-0432.c.6517425.v1
https://doi.org/10.1158/1078-0432.c.6517425.v1
Autor:
Lawrence D. Mayer, Andrew S. Janoff
Publikováno v:
Molecular Interventions. 7:216-223
Cancer chemotherapy treatments typically employ drug combinations in which the dose of each agent is pushed to the brink of unacceptable toxicity; however, emerging evidence indicates that this approach may not be providing optimal efficacy due to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369440574274c8a2a68edb566ac2da65
https://doi.org/10.1124/mi.7.4.8
https://doi.org/10.1124/mi.7.4.8
Autor:
N. Dos Santos, Lawrence D. Mayer, Wai Ming Li, Gigi N.C. Chiu, Murray S. Webb, Christine Allen, Ryan C. Gallagher, Sharon Johnstone, Marcel B. Bally, Y. Shu, Andrew S. Janoff
Publikováno v:
Bioscience Reports. 22:225-250
The presence of poly(ethylene glycol) (PEG) at the surface of a liposomal carrier has been clearly shown to extend the circulation lifetime of the vehicle. To this point, the extended circulation lifetime that the polymer affords has been attributed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1cb873d9e319b1743644a34f18452c
https://doi.org/10.1023/a:1020186505848
https://doi.org/10.1023/a:1020186505848
Autor:
James Schupsky, Josephine Nguyen, Cathy Herbert, Donald J. Hirsh, Imran Ahmad, Andrew S. Janoff, Christopher J. Fecko, Gregg R. Masters, Shaukat Ali, Walter Perkins, Xingong Li, JinKeun Lee, Eric Mayhew
Publikováno v:
International Journal of Pharmaceutics. 200:27-39
The development of stable spherical lipid-coated drug particles that are termed 'lipocores' is reported here. Unlike conventional lipid-based particles (i.e. liposomes, emulsions, micelles), these particles are comprised solely of a core of a poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25dde1ec0bed4939e1766b0da8519ea6
https://doi.org/10.1016/s0378-5173(00)00329-x
https://doi.org/10.1016/s0378-5173(00)00329-x
Publikováno v:
Cancer Immunology, Immunotherapy. 48:569-578
Association of the ether lipid, 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine (ET-18-OCH3) with liposomes (ELL-12) reduces acute toxicity while maintaining or enhancing anticancer activity in experimental tumor models. ELL-12 has been shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a3cb22c6651dcf5fd080ff2e047bec
https://doi.org/10.1007/pl00006675
https://doi.org/10.1007/pl00006675
Publikováno v:
Journal of Liposome Research. 10:29-41
The present study describes a new phase-specific assay system for the detection of anti-phospholipid antibodies, based on the finding by 3IP NMR analysis that phospholipid can be quantitatively ret...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e841f558188545de44cafefd911abe0
https://doi.org/10.3109/08982100009031093
https://doi.org/10.3109/08982100009031093
Publikováno v:
Biophysical Journal. 78(1):246-256
High sensitivity differential scanning calorimetry (DSC) was used to investigate the thermotropic phase properties of binary mixtures of disaturated phosphocholines (PCs) and alpha-bromoacyl taxane derivatives. The alpha-bromoacyl taxanes were synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1484c0fed85f5ebc728a2b364334a6c7
Publikováno v:
Journal of Liposome Research. 10:15-27
Doxorubicin loads quite efficiently into preformed citrate containing liposomes ( 95% loading for drug/lipid as high as 1:1 w/w. In fact, doxorubicin's loading was found to exceed theoretical predictions because it forms an insoluble complex with cit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05aae119e9c788e75970411cbd8455ac
https://doi.org/10.3109/08982100009031092
https://doi.org/10.3109/08982100009031092
Publikováno v:
Cell Biology International. 23:817-828
1-O-Octadecyl-2-O-methyl-glycero-3-phosphocholine (ET-18-OCH(3)) selectively inhibits the growth of cancer cells. Here we show that in some cell types ET-18-OCH(3)and liposome-associated ET-18-OCH(3)inhibit cell division without concurrent inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f2b97fe12fc57942a26abb1c91f41c
https://doi.org/10.1006/cbir.1999.0478
https://doi.org/10.1006/cbir.1999.0478