Zobrazeno 1 - 10
of 971
pro vyhledávání: '"A S, Geha"'
Autor:
Mehdi Benamar, Qian Chen, Janet Chou, Amélie M. Julé, Rafik Boudra, Paola Contini, Elena Crestani, Peggy S. Lai, Muyun Wang, Jason Fong, Shira Rockwitz, Pui Lee, Tsz Man Fion Chan, Ekin Zeynep Altun, Eda Kepenekli, Elif Karakoc-Aydiner, Ahmet Ozen, Perran Boran, Fatih Aygun, Pinar Onal, Ayse Ayzit Kilinc Sakalli, Haluk Cokugras, Metin Yusuf Gelmez, Fatma Betul Oktelik, Esin Aktas Cetin, Yuelin Zhong, Maria Lucia Taylor, Katherine Irby, Natasha B. Halasa, Elizabeth H. Mack, Overcoming COVID-19 Investigators, Sara Signa, Ignazia Prigione, Marco Gattorno, Nicola Cotugno, Donato Amodio, Raif S. Geha, Mary Beth Son, Jane Newburger, Pankaj B. Agrawal, Stefano Volpi, Paolo Palma, Ayca Kiykim, Adrienne G. Randolph, Gunnur Deniz, Safa Baris, Raffaele De Palma, Klaus Schmitz-Abe, Louis-Marie Charbonnier, Lauren A. Henderson, Talal A. Chatila
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 1 (2023)
Multisystem inflammatory syndrome in children (MIS-C) evolves in some pediatric patients following acute infection with SARS-CoV-2 by hitherto unknown mechanisms. Whereas acute-COVID-19 severity and outcomes were previously correlated with Notch4 exp
Externí odkaz:
https://doaj.org/article/a39c807bcee64be782682857c935eead
Autor:
Erin Janssen, Zachary Peters, Mohammed F. Alosaimi, Emma Smith, Elena Milin, Kelsey Stafstrom, Jacqueline G. Wallace, Craig D. Platt, Janet Chou, Yasmeen S. El Ansari, Tariq Al Farsi, Najim Ameziane, Ruslan Al-Ali, Maria Calvo, Maria Eugenia Rocha, Peter Bauer, Nouriya Abbas Al-Sannaa, Nashat Faud Al Sukaiti, Abdullah A. Alangari, Aida M. Bertoli-Avella, Raif S. Geha
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 20 (2022)
CBL-B is an E3 ubiquitin ligase that ubiquitinates proteins downstream of immune receptors to downregulate positive signaling cascades. Distinct homozygous mutations in CBLB were identified in 3 unrelated children with early-onset autoimmunity, one o
Externí odkaz:
https://doaj.org/article/39932b8ac161497cb818bcd607e93a5c
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Atopic disorders, including atopic dermatitis, food and environmental allergies, and asthma, are increasingly prevalent diseases. Atopic disorders are often associated with eosinophilia, driven by T helper type 2 (Th2) immune responses, and triggered
Externí odkaz:
https://doaj.org/article/aa170f346fff40bcb864a737dca4c867
Autor:
Juan-Manuel Leyva-Castillo, Mrinmoy Das, Jennifer Kane, Maria Strakosha, Sonal Singh, Daniel Sen Hoi Wong, Alexander R. Horswill, Hajime Karasuyama, Frank Brombacher, Lloyd S. Miller, Raif S. Geha
Publikováno v:
JCI Insight, Vol 6, Iss 21 (2021)
Superficial cutaneous Staphylococcus aureus (S. aureus) infection in humans can lead to soft tissue infection, an important cause of morbidity and mortality. IL-17A production by skin TCRγδ+ cells in response to IL-1 and IL-23 produced by epithelia
Externí odkaz:
https://doaj.org/article/f92c5bebf6394434bab77102e9cc1d06
Autor:
Mayara Garcia de Mattos Barbosa, Adam R. Lefferts, Daniel Huynh, Hui Liu, Yu Zhang, Beverly Fu, Jenna Barnes, Milagros Samaniego, Richard J. Bram, Raif S. Geha, Ariella Shikanov, Eline T. Luning Prak, Evan A. Farkash, Jeffrey L. Platt, Marilia Cascalho
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
Host genes define the severity of inflammation and immunity but specific loci doing so are unknown. Here we show that TNF receptor superfamily member 13B (TNFRSF13B) variants, which enhance defense against certain pathogens, also control immune-media
Externí odkaz:
https://doaj.org/article/a070c085b731448ba55137aa11437ce9
Publikováno v:
JID Innovations, Vol 1, Iss 3, Pp 100059- (2021)
In a new article published in JID Innovations, Nakatani-Kusakabe et al. (2021) show that type 2 innate lymphoid cells (ILC2s) in the skin of mice with IL-33 overexpression in keratinocytes are heterogeneous and consist of two distinct populations: sk
Externí odkaz:
https://doaj.org/article/17f669241eb54d7a9d91ccbb8a612b3e
Autor:
Selina Jessica Keppler, Marianne Burbage, Francesca Gasparrini, Lara Hartjes, Shweta Aggarwal, Michel J. Massaad, Raif S. Geha, Andreas Bruckbauer, Facundo D. Batista
Publikováno v:
Cell Reports, Vol 24, Iss 3, Pp 619-629 (2018)
Summary: Wiskott-Aldrich syndrome protein (WASp) is a main cytoskeletal regulator in B cells. WASp-interacting protein (WIP) binds to and stabilizes WASp but also interacts with actin. Using mice with a mutated actin binding domain of WIP (WIPΔABD),
Externí odkaz:
https://doaj.org/article/a8e1adbe9bb743a7bee7ea3fae541c3a
Autor:
Amlan Biswas, Dror S. Shouval, Alexandra Griffith, Jeremy A. Goettel, Michael Field, Yu Hui Kang, Liza Konnikova, Erin Janssen, Naresh Singh Redhu, Adrian J. Thrasher, Talal Chatila, Vijay K. Kuchroo, Raif S Geha, Luigi D. Notarangelo, Sung-Yun Pai, Bruce H. Horwitz, Scott B. Snapper
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Deficiency in Wiskott-Aldrich syndrome protein (WASP) has been associated with autoimmune colitis, but the underlying mechanism is still unclear. Here the authors show that WASP deficiency is associated with defective WASP/DOCK8 complex formation, al
Externí odkaz:
https://doaj.org/article/d6407c36dbee4770a2372e3380f5d795
Autor:
Waleed Al-Herz, Janet Chou, Ottavia Maria Delmonte, Michel J. Massaad, Wayne Bainter, Riccardo Castagnoli, Christoph Klein, Yenan T. Bryceson, Raif S. Geha, Luigi D. Notarangelo
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
Objective: To present the genetic causes of patients with primary immune deficiencies (PIDs) in Kuwait between 2004 and 2017.Methods: The data was obtained from the Kuwait National Primary Immunodeficiency Disorders Registry. Genomic DNA from patient
Externí odkaz:
https://doaj.org/article/a7f287977a63457aaec2373277ea6188
Autor:
Ali Sobh, Doaa Mosad Mosa, Mayada S Zeid, Omnia Salem, Marwa H Elnagdy, Nada M El-Hadidy, Sara A Bahgat, Ragheed Rizk, Raif S Geha
Purpose Inborn errors of immunity (IEI) comprise a heterogeneous group of monogenic disorders with wide spectrum of clinical manifestations. The aim of this study is to describe epidemiologic, clinical, and genetic features of patients with inborn er
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b2bbd09ffc3075aa736ea1d5b880be4
https://doi.org/10.21203/rs.3.rs-2428688/v1
https://doi.org/10.21203/rs.3.rs-2428688/v1
