Zobrazeno 1 - 10
of 348
pro vyhledávání: '"A S, Gamis"'
Autor:
Anneke D. van Dijk, Fieke W. Hoff, Yihua Qiu, Stefan E. Hubner, Robin L. Go, Vivian R. Ruvolo, Amanda R. Leonti, Robert B. Gerbing, Alan S. Gamis, Richard Aplenc, Edward A. Kolb, Todd A. Alonzo, Soheil Meshinchi, Eveline S. J. M. de Bont, Terzah M. Horton, Steven M. Kornblau
Publikováno v:
Cancers, Vol 16, Iss 8, p 1448 (2024)
The addition of the proteasome inhibitor bortezomib to standard chemotherapy did not improve survival in pediatric acute myeloid leukemia (AML) when all patients were analyzed as a group in the Children’s Oncology Group phase 3 trial AAML1031 (NCT0
Externí odkaz:
https://doaj.org/article/993a21e3ecff4ccfa59731e0c4b20ed8
Autor:
Benjamin J. Huang, Jenny L. Smith, Jason E. Farrar, Yi-Cheng Wang, Masayuki Umeda, Rhonda E. Ries, Amanda R. Leonti, Erin Crowgey, Scott N. Furlan, Katherine Tarlock, Marcos Armendariz, Yanling Liu, Timothy I. Shaw, Lisa Wei, Robert B. Gerbing, Todd M. Cooper, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Jeffrey Rubnitz, Jing Ma, Jeffery M. Klco, Xiaotu Ma, Todd A. Alonzo, Timothy Triche, Soheil Meshinchi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Relapsed pediatric acute myeloid leukemia is associated with poor prognosis. Here, the authors use RNA-seq data from 1503 primary samples to create a combined transcriptional and cytomolecular signature to improve relapse risk prediction.
Externí odkaz:
https://doaj.org/article/25d98e54e2234ca19a9e20931766c2ae
Autor:
Eline J.M. Bertrums, Jenny L. Smith, Lauren Harmon, Rhonda E. Ries, Yi-Cheng J. Wang, Todd A. Alonzo, Andrew J. Menssen, Karen M. Chisholm, Amanda R. Leonti, Katherine Tarlock, Fabiana Ostronoff, Era L. Pogosova-Agadjanyan, Gertjan J.L. Kaspers, Henrik Hasle, Michael Dworzak, Christiane Walter, Nora Muhlegger, Cristina Morerio, Laura Pardo, Betsy Hirsch, Susana Raimondi, Todd M. Cooper, Richard Aplenc, Alan S. Gamis, Edward A. Kolb, Jason E. Farrar, Derek Stirewalt, Xiaotu Ma, Tim I. Shaw, Scott N. Furlan, Lisa Eidenschink Brodersen, Michael R. Loken, Marry M. van den Heuvel-Eibrink, C. Michel Zwaan, Timothy J. Triche, Bianca F. Goemans, Soheil Meshinchi
Publikováno v:
Haematologica, Vol 108, Iss 8 (2023)
NUP98 fusions comprise a family of rare recurrent alterations in AML, associated with adverse outcomes. In order to define the underlying biology and clinical implications of this family of fusions, we performed comprehensive transcriptome, epigenome
Externí odkaz:
https://doaj.org/article/831b66d955b24822ab485927eae2ccd2
Autor:
Fieke W. Hoff, Anneke D. van Dijk, Yihua Qiu, Chenyue W. Hu, Rhonda E. Ries, Andrew Ligeralde, Gaye N. Jenkins, Robert B. Gerbing, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Todd A. Alonzo, Soheil Meshinchi, Amina A. Qutub, Eveline S.J.M. de Bont, Terzah M. Horton, Steven M. Kornblau
Publikováno v:
Haematologica, Vol 107, Iss 10 (2022)
Pediatric acute myeloid leukemia (AML) remains a fatal disease for at least 30% of patients, stressing the need for improved therapies and better risk stratification. As proteins are the unifying feature of (epi)genetic and environmental alterations,
Externí odkaz:
https://doaj.org/article/ec910a7b013b405a849aaa5ec9509aa0
Autor:
Jason E. Farrar, Jenny L. Smith, Megan Othus, Benjamin J. Huang, Yi-Cheng Wang, Rhonda Ries, Tiffany Hylkema, Era L. Pogosova-Agadjanyan, Sneha Challa, Amanda Leonti, Timothy I. Shaw, Timothy J. Triche, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Xiaotu Ma, Derek L. Stirewalt, Todd A. Alonzo, Soheil Meshinchi
Publikováno v:
Journal of Clinical Oncology. 41:2949-2962
PURPOSE Optimized strategies for risk classification are essential to tailor therapy for patients with biologically distinctive disease. Risk classification in pediatric acute myeloid leukemia (pAML) relies on detection of translocations and gene mut
Autor:
Mareike Rasche, Martin Zimmermann, Emma Steidel, Todd Alonzo, Richard Aplenc, Jean-Pierre Bourquin, Heidrun Boztug, Todd Cooper, Alan S. Gamis, Robert B. Gerbing, Iveta Janotova, Jan-Henning Klusmann, Thomas Lehrnbecher, Nora Mühlegger, Nils v. Neuhoff, Naghmeh Niktoreh, Lucie Sramkova, Jan Stary, Katharina Waack, Christiane Walter, Ursula Creutzig, Michael Dworzak, Gertjan Kaspers, Edward Anders Kolb, Dirk Reinhardt
Publikováno v:
Cancers, Vol 13, Iss 10, p 2336 (2021)
Post-relapse therapy remains critical for survival in children with acute myeloid leukemia (AML). We evaluated survival, response and prognostic variables following relapse in independent cooperative group studies conducted by COG and the population-
Externí odkaz:
https://doaj.org/article/6ccab8b7925f4fe1832f776d8b8301b8
Autor:
Soheil Meshinchi, Alan S. Gamis, Michael R. Loken, Richard Aplenc, Jessica A. Pollard, Lillian Sung, Betsy A. Hirsch, Susana C. Raimondi, Robert B. Gerbing, Todd A. Alonzo, Katherine Tarlock
CTC v3.0 toxicities grade 3 or higher for patients in the No-GO and GO cohorts treated on AAML03P1 and AAML0531.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe4f237538683d57a9f94c776139671
https://doi.org/10.1158/1078-0432.22460757.v1
https://doi.org/10.1158/1078-0432.22460757.v1
Autor:
Soheil Meshinchi, Daniela S. Gerhard, Malcolm A. Smith, David A. Wheeler, Alan S. Gamis, Lora R. Lewis, Navin Rustagi, Ninad Dewal, Donna M. Muzny, Leandro Hermida, Patee Gesuwan, Tanja M. Davidsen, Jaime M. Guidry Auvil, Todd A. Alonzo, Lisa R. Trevino, Oliver A. Hampton, Daniel Wai, Rhonda E. Ries, Heather L. Schuback, Jason E. Farrar
Demographic Information of Patient Cohort. A) Age category of patients. B) Cytogenetic category.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5073cf6db09b01277dbc1eb3e614631c
https://doi.org/10.1158/0008-5472.22410521.v1
https://doi.org/10.1158/0008-5472.22410521.v1
Autor:
Nicholas H.G. Holford, Alan S. Gamis, K. Scott Baker, Jeffrey S. Barrett, Meagan J. Bemer, Jeannine S. McCune
PDF file 45K, Empirical estimates of allometric exponents; correlation of between subject and between occasion variabilities of pharmacokinetic parameters; and evaluation of alternative models created from pediatric datasets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d094657dc0c7c241d06f1beb886b92c
https://doi.org/10.1158/1078-0432.22449563.v1
https://doi.org/10.1158/1078-0432.22449563.v1
Autor:
Nicholas H.G. Holford, Alan S. Gamis, K. Scott Baker, Jeffrey S. Barrett, Meagan J. Bemer, Jeannine S. McCune
PDF file 62K, Predicted initial IV busulfan dose for daily administration to achieve a busulfan target Css of 770 ng/mL using the normal fat mass (NFM) model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17357b6bfd4215b087f641188076d874
https://doi.org/10.1158/1078-0432.22449566
https://doi.org/10.1158/1078-0432.22449566