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Akademický článek

Low potassium activation of proximal mTOR/AKT signaling is mediated by Kir4.2

Autor: Yahua Zhang, Fabian Bock, Mohammed Ferdaus, Juan Pablo Arroyo, Kristie L Rose, Purvi Patel, Jerod S. Denton, Eric Delpire, Alan M. Weinstein, Ming-Zhi Zhang, Raymond C. Harris, Andrew S. Terker

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract The renal epithelium is sensitive to changes in blood potassium (K+). We identify the basolateral K+ channel, Kir4.2, as a mediator of the proximal tubule response to K+ deficiency. Mice lacking Kir4.2 have a compensated baseline phenotype w

Externí odkaz: https://doaj.org/article/466eefddbfcf433986c90e461a6b9ab4

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Akademický článek

The Seroepidemiology of Strongyloides stercoralis Infection in Jamaica

Autor: Anique Vanessa Chin, Tamara Thompson, Cobrini S. Denton, John F. Lindo

Publikováno v: Journal of Tropical Medicine, Vol 2024 (2024)

Strongyloides stercoralis is a soil-transmitted helminth which is distributed predominately throughout tropical and subtropical regions and is considered a neglected tropical disease. Due to low larval output, traditional microscopic methods lack sen

Externí odkaz: https://doaj.org/article/f272ab0132b54a06a5722f5675cb897f

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Akademický článek

A SWELL time to develop the molecular pharmacology of the volume-regulated anion channel (VRAC)

Autor: Eric E. Figueroa, Jerod S. Denton

Publikováno v: Channels, Vol 16, Iss 1, Pp 27-36 (2022)

Newly emerging roles of LRRC8 volume-regulated anion channels (VRAC) raise important questions about the therapeutic potential of VRAC in the treatment of epilepsy, type 2 diabetes, and other human diseases. A critical barrier to evaluating whether V

Externí odkaz: https://doaj.org/article/1309af476b9141f4a355509a3ed9d3ba

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Akademický článek

Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly

Autor: Hirohide Takahashi, Toshiki Yamada, Jerod S Denton, Kevin Strange, Erkan Karakas

Publikováno v: eLife, Vol 12 (2023)

Volume-regulated anion channels (VRACs) mediate volume regulatory Cl- and organic solute efflux from vertebrate cells. VRACs are heteromeric assemblies of LRRC8A-E proteins with unknown stoichiometries. Homomeric LRRC8A and LRRC8D channels have a sma

Externí odkaz: https://doaj.org/article/aa7ea42837e04d9ba238be46ae7f3f71

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Akademický článek

Pattern and timing of diversification in the African freshwater fish genus Distichodus (Characiformes: Distichodontidae)

Autor: Jairo Arroyave, John S. S. Denton, Melanie L. J. Stiassny

Publikováno v: BMC Evolutionary Biology, Vol 20, Iss 1, Pp 1-28 (2020)

Abstract Background Distichodus is a clade of tropical freshwater fishes currently comprising 25 named species distributed continent-wide throughout the Nilo-Sudan and most Sub-Saharan drainages. This study investigates the phylogenetic relationships

Externí odkaz: https://doaj.org/article/d8408acc24704a7eaa05ef7939aeb59c

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Akademický článek

Lactate activation of α-cell KATP channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca2+ entry

Autor: Karolina E. Zaborska, Prasanna K. Dadi, Matthew T. Dickerson, Arya Y. Nakhe, Ariel S. Thorson, Charles M. Schaub, Sarah M. Graff, Jade E. Stanley, Roy S. Kondapavuluru, Jerod S. Denton, David A. Jacobson

Publikováno v: Molecular Metabolism, Vol 42, Iss , Pp 101056- (2020)

Objective: Elevations in pancreatic α-cell intracellular Ca2+ ([Ca2+]i) lead to glucagon (GCG) secretion. Although glucose inhibits GCG secretion, how lactate and pyruvate control α-cell Ca2+ handling is unknown. Lactate enters cells through monoca

Externí odkaz: https://doaj.org/article/739b7a2b2b794efa9353527289b42407

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