Zobrazeno 1 - 10 of 50 pro vyhledávání: '"A S, Alshetaili"'
1
Akademický článek
Design, statistical optimization, and characterization of Esculin-loaded transliposome nanogel for topical delivery: In-vitro, ex vivo study and dermatokinetic evaluation
Autor: Abdullah S. Alshetaili
Publikováno v: Journal of King Saud University: Science, Vol 36, Iss 5, Pp 103166- (2024)
The purpose of this study was to prepare and optimise an Esculin-loaded transliposome (ECL-TL) for the dermal administration of ECL for skin cancer treatment. The ECL-TL formulation effectively produced closed lamellar vesicles with in-vitro drug rel
Externí odkaz: https://doaj.org/article/d369f67691dd45b09c97e9cfdc33bb38
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2
Akademický článek
Optimization of tamoxifen solubility in carbon dioxide supercritical fluid and investigating other molecular targets using advanced artificial intelligence models
Autor: Saad M. Alshahrani, Abdullah S. Alshetaili, Munerah M. Alfadhel, Amany Belal, Mohammad A. S. Abourehab, Ahmed Al Saqr, Bjad K. Almutairy, Kumar Venkatesan, Amal M. Alsubaiyel, Mahboubeh Pishnamazi
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Particle size, shape and morphology can be considered as the most significant functional parameters, their effects on increasing the performance of oral solid dosage formulation are indisputable. Supercritical Carbon dioxide fluid (SCCO2) te
Externí odkaz: https://doaj.org/article/a5b044c243434b14926bc99f822a947d
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3
Akademický článek
Computational simulation and target prediction studies of solubility optimization of decitabine through supercritical solvent
Autor: Saad M. Alshahrani, Bjad K. Almutairy, Munerah M. Alfadhel, Amany Belal, Mohammed A. S. Abourehab, Ahmed Al. Saqr, Abdullah S. Alshetaili, Kumar Venkatesan, Amal M. Alsubaiyel, Mahboubeh Pishnamazi
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Computational analysis of drug solubility was carried out using machine learning approach. The solubility of Decitabine as model drug in supercritical CO2 was studied as function of pressure and temperature to assess the feasibility of that
Externí odkaz: https://doaj.org/article/226619c59d614527adc3cae5ce653c33
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5
Akademický článek
Application of CO2 Supercritical Fluid to Optimize the Solubility of Oxaprozin: Development of Novel Machine Learning Predictive Models
Autor: Saad M. Alshahrani, Ahmed Al Saqr, Munerah M. Alfadhel, Abdullah S. Alshetaili, Bjad K. Almutairy, Amal M. Alsubaiyel, Ali H. Almari, Jawaher Abdullah Alamoudi, Mohammed A. S. Abourehab
Publikováno v: Molecules, Vol 27, Iss 18, p 5762 (2022)
Over the last years, extensive motivation has emerged towards the application of supercritical carbon dioxide (SCCO2) for particle engineering. SCCO2 has great potential for application as a green and eco-friendly technique to reach small crystalline
Externí odkaz: https://doaj.org/article/d1f743f0fc9145478444188af985bbb3
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6
Akademický článek
Enhancing the Poor Flow and Tableting Problems of High Drug-Loading Formulation of Canagliflozin Using Continuous Green Granulation Process and Design-of-Experiment Approach
Autor: Bjad K. Almutairy, El-Sayed Khafagy, Ahmed Alalaiwe, Mohammed F. Aldawsari, Saad M. Alshahrani, Bader B. Alsulays, Abdullah S. Alshetaili, Sultan M. Alshehri, Mohamed H. Fayed
Publikováno v: Pharmaceuticals, Vol 13, Iss 12, p 473 (2020)
Maximization of drug-loading can significantly reduce the size of dosage form and consequently decrease the cost of manufacture. In this research, two challenges were addressed: poor flow and tableting problems of high-drug loading (>70%) formulation
Externí odkaz: https://doaj.org/article/5e190f96a9ba47b98955ca155fd6cdfa
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7
In silico identification of MicroRNAs targeting the key nucleator of stress granules, G3BP: Promising therapeutics for SARS-CoV-2 infection
Autor: Khalid Anwer, Bjad K. Almutairy, Nemat Ali, Abdullah S. Alshetaili
Publikováno v: Saudi Journal of Biological Sciences, Vol 28, Iss 12, Pp 7499-7504 (2021)
Saudi Journal of Biological Sciences
Stress granules (SGs) are non-membrane ribonucleoprotein condensates formed in response to environmental stress conditions via liquid-liquid phase separation (LLPS). SGs are involved in the pathogenesis of aging and aging-associated diseases, cancers
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3721d8cd1479888529d22709b0157b3
http://www.sciencedirect.com/science/article/pii/S1319562X21007336
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9
Akademický článek
Preparation, Evaluation and Bioavailability Studies of Eudragit Coated PLGA Nanoparticles for Sustained Release of Eluxadoline for the Treatment of Irritable Bowel Syndrome
Autor: Md. K. Anwer, Ramadan Al-Shdefat, Essam Ezzeldin, Saad M. Alshahrani, Abdullah S. Alshetaili, Muzaffar Iqbal
Publikováno v: Frontiers in Pharmacology, Vol 8 (2017)
Eluxadoline is a newly approved orally administered drug used for the treatment of Irritable Bowel Syndrome with Diarrhea. It is reported as a poorly water-soluble drug due to which its dissolution rate and oral bioavailability are very poor. In this
Externí odkaz: https://doaj.org/article/efe1b8ff58214bd9b113b790404928c6
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10
Application of CO
Autor: Saad M, Alshahrani, Ahmed Al, Saqr, Munerah M, Alfadhel, Abdullah S, Alshetaili, Bjad K, Almutairy, Amal M, Alsubaiyel, Ali H, Almari, Jawaher Abdullah, Alamoudi, Mohammed A S, Abourehab
Publikováno v: Molecules (Basel, Switzerland). 27(18)
Over the last years, extensive motivation has emerged towards the application of supercritical carbon dioxide (SCCO
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbe3b5a6c539e1cbb1bb75b19c6b6b32
https://pubmed.ncbi.nlm.nih.gov/36144490
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