Zobrazeno 1 - 10
of 133
pro vyhledávání: '"A R Wakade"'
Publikováno v:
Journal of Neurochemistry. 67:557-565
We demonstrate that 1-methyl-4-phenylpyridinium (MPP + ) is toxic to chick peripheral sympathetic neurons maintained in culture in the presence of nerve growth factor (NGF). When MPP + was added to the culture medium at the time the neurons were plat
Publikováno v:
Journal of Neurochemistry. 71:1889-1897
Removal of nerve growth factor (NGF) from sympathetic neurons initiates a neuronal death program and apoptosis. We show that pituitary adenylyl cyclase-activating polypeptide (PACAP) prevents apoptosis in NGF-deprived sympathetic neurons. PACAP (100
Publikováno v:
Journal of Neurochemistry. 78:1243-1255
We characterized changes in membrane currents and the cytosolic Ca2+ concentration, [Ca2+]i, in response to caffeine, and compared them with those in response to muscarine using the perforated patch-clamp technique and fura-2 microfluorimetry in guin
Publikováno v:
Molecular Neurobiology. 23:137-154
Inhibitory effect of adenosine on the isolated heart muscle and vascular system were first described in 1929. Since then, numerous reviews have been published on the diverse actions of this nucleoside on a wide variety of cell types. Essentially all
Autor:
Dimitry Leontiv, Arun R. Wakade
Publikováno v:
Annals of the New York Academy of Sciences. 865:176-180
Publikováno v:
Neuroscience Letters. 252:163-166
Our past work on nucleoside toxicity in sympathetic neurons has clearly revealed that adenosine and 2'-deoxyadenosine (dAdo) have different mechanisms of action in inducing apoptotic death. For example, adenosine is toxic to neurons only during early
Publikováno v:
Neuroscience Letters. 248:187-190
Our previous work has established that adenosine is toxic to chick embryonic sympathetic neurons and kills freshly plated neurons by a process of apoptosis. Although the exact mechanism remains unknown, we found that phosphorylation of adenosine was
Publikováno v:
The Journal of Physiology. 494:67-75
1. The biochemical basis for differences in noradrenaline (NA) transporter function between chromaffin cells in the adrenal medulla and those maintained in primary culture was investigated. 2. Intact adrenal medullae of neonatal rats accumulated smal
Publikováno v:
The Journal of Physiology. 488:587-600
1. The contribution of target cells in controlling the functional properties of sympathetic neurons was investigated using pure neuronal cultures and co-cultures of neurons with their physiological target cells. 2. Chick embryo sympathetic neurons cu
Publikováno v:
The Journal of Physiology. 488:123-138
1. A newly found action of adenosine in neurons, which may have an important physiological function in the growth and development of the sympathetic nervous system, is described. Adenosine (1-100 microM) inhibited neurite outgrowth within the first 2