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Interleukin-36 (IL-36) Ligands Require Processing for Full Agonist (IL-36α, IL-36β, and IL-36γ) or Antagonist (IL-36Ra) Activity

Autor: Min Shen, John E. Sims, Jason Douangpanya, Jennifer E. Towne, Brian P. Lipsky, Christopher A. Gabel, Blair R. Renshaw

Publikováno v: Journal of Biological Chemistry. 286:42594-42602

IL-36α, IL-36β, and IL-36γ (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36Ra (formerly IL-1F5) has been reported to antagonize IL-36γ. Howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a850ab0e028b8737bdd2509dfa3d52d8
https://doi.org/10.1074/jbc.m111.267922

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A novel mutation of IL1RN in the deficiency of interleukin-1 receptor antagonist syndrome: Description of two unrelated cases from Brazil

Autor: Mazen Osman, Hatem El-Shanti, Asma Al-Dosari, Raphaela Goldbach-Mansky, Peter W. Kim, Clovis A. Silva, John E. Sims, Michael Brown, Blair R. Renshaw, Adriana Almeida de Jesus, T. Pham, Barbara Yang, Jamil Al-Alami, Débora Romeo Bertola, Polly J. Ferguson, Magda Carneiro-Sampaio, Massimo Gadina, Ken Schooley

Publikováno v: Arthritis & Rheumatism. 63:4007-4017

Autoinflammatory diseases are a group of disorders characterized by systemic inflammation without high-titer autoantibodies or antigen-specific T cells, and their etiology is thought to be attributable to dysregulation of innate immunity (1,2). A num

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed7f0bc26ee9855a12cf8b8e4131912b
https://doi.org/10.1002/art.30588

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A Single Amino Acid Difference between Human and Monkey Interleukin (IL)-1β Dictates Effective Binding to Soluble Type II IL-1 Receptor

Autor: Heather Moore, Della Friend, Blair R. Renshaw, Zachary Anderson, Randal R. Ketchem, Dirk E. Smith, John E. Sims

Publikováno v: Journal of Biological Chemistry. 277:47619-47625

Soluble type II interleukin (IL)-1 receptor (sIL1R-II) binds human IL-1beta with high affinity and neutralizes its activity. Recombinant sIL1R-II is considered a potentially useful anti-IL-1 therapeutic, and preclinical studies have been undertaken w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6987b8749bcaebaf14f64c2d451d13
https://doi.org/10.1074/jbc.m206636200

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Identification and Characterization of Two Members of a Novel Class of the Interleukin-1 Receptor (IL-1R) Family

Autor: Blair R. Renshaw, Teresa L. Born, Kirsten E. Garka, Jeanette S. Bertles, John E. Sims, Dirk E. Smith

Publikováno v: Journal of Biological Chemistry. 275:29946-29954

Two novel members of the interleukin-1 receptor (IL-1R) family, identified by homology searches of human genomic sequence data bases, are described. The genes have been named according to their structural features: TIGIRR-1(three immunoglobulin domai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84cefcb260b738f9a3ff9e18ab1bba07
https://doi.org/10.1074/jbc.m004077200

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Cloning of a Putative Ligand for the T1/ST2 Receptor

Autor: Takahiro Taguchi, Gonosuke Sonoda, Blair R. Renshaw, Timothy P. Bonnert, Jennifer L. Slack, Steven K. Dower, Joseph R. Testa, John E. Sims, Margit A. Gayle

Publikováno v: Journal of Biological Chemistry. 271:5784-5789

T1/ST2 is a receptor-like molecule homologous to the type I interleukin-1 receptor. Despite this sequence similarity, we have been unable to demonstrate binding of T1/ST2 to any of the three interleukin-1 species. In searching for a ligand for T1/ST2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4155e554c3d4adfd527df282529d7a5e
https://doi.org/10.1074/jbc.271.10.5784

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Humoral immune responses in CD40 ligand-deficient mice

Autor: B Wright, R J Armitage, B R Renshaw, W C Fanslow, B L Davison, Charles R. Maliszewski, D Liggitt, K A Campbell

Publikováno v: The Journal of Experimental Medicine

Individuals with X-linked hyper-IgM syndrome fail to express functional CD40 ligand (CD40L) and, as a consequence, are incapable of mounting protective antibody responses to opportunistic bacterial infections. To address the role of CD40L in humoral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ac4a90a916f6ff9cb5b90bdd36c11b
https://doi.org/10.1084/jem.180.5.1889

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