Zobrazeno 1 - 10
of 231
pro vyhledávání: '"A R Nebreda"'
Autor:
Joan Pous, Blazej Baginski, Pau Martin-Malpartida, Lorena González, Margherita Scarpa, Eric Aragon, Lidia Ruiz, Rebeca A. Mees, Javier Iglesias-Fernández, Modesto Orozco, Angel R. Nebreda, Maria J. Macias
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Many functional aspects of the protein kinase p38α have been illustrated by more than three hundred structures determined in the presence of reducing agents. These structures correspond to free forms and complexes with activators, substrate
Externí odkaz:
https://doaj.org/article/5db9dbcc41a443aea05c543a36e1e73e
Autor:
Lorena González, Lucía Díaz, Joan Pous, Blazej Baginski, Anna Duran-Corbera, Margherita Scarpa, Isabelle Brun-Heath, Ana Igea, Pau Martin-Malpartida, Lidia Ruiz, Chiara Pallara, Mauricio Esguerra, Francesco Colizzi, Cristina Mayor-Ruiz, Ricardo M. Biondi, Robert Soliva, Maria J. Macias, Modesto Orozco, Angel R. Nebreda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract p38α is a versatile protein kinase that can control numerous processes and plays important roles in the cellular responses to stress. Dysregulation of p38α signaling has been linked to several diseases including inflammation, immune disord
Externí odkaz:
https://doaj.org/article/875e0b5f72914dd0a22c1161dc475f7f
Autor:
Laura Gonzalez, Ana Domingo-Muelas, Pere Duart-Abadia, Marc Nuñez, Petra Mikolcevic, Elisabet Llonch, Monica Cubillos-Rojas, Begoña Cánovas, Stephen M.A. Forrow, Jose Manuel Morante-Redolat, Isabel Fariñas, Angel R. Nebreda
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106202- (2023)
Summary: In the adult mammalian brain, most neural stem cells (NSCs) are held in a reversible state of quiescence, which is essential to avoid NSC exhaustion and determine the appropriate neurogenesis rate. NSCs of the mouse adult subependymal niche
Externí odkaz:
https://doaj.org/article/5b85c5ac0b1f4b39af7c6e23dd218ca3
Autor:
Clara Suñer, Annarita Sibilio, Judit Martín, Chiara Lara Castellazzi, Oscar Reina, Ivan Dotu, Adrià Caballé, Elisa Rivas, Vittorio Calderone, Juana Díez, Angel R Nebreda, Raúl Méndez
Publikováno v:
eLife, Vol 11 (2022)
Chronic inflammation is a major cause of disease. Inflammation resolution is in part directed by the differential stability of mRNAs encoding pro-inflammatory and anti-inflammatory factors. In particular, tristetraprolin (TTP)-directed mRNA deadenyla
Externí odkaz:
https://doaj.org/article/4e3e383266cb49608da7a9a2ea87fedf
Autor:
Bahareh Eftekharzadeh, Varuna C. Banduseela, Giulio Chiesa, Paula Martínez-Cristóbal, Jennifer N. Rauch, Samir R. Nath, Daniel M. C. Schwarz, Hao Shao, Marta Marin-Argany, Claudio Di Sanza, Elisa Giorgetti, Zhigang Yu, Roberta Pierattelli, Isabella C. Felli, Isabelle Brun-Heath, Jesús García, Ángel R. Nebreda, Jason E. Gestwicki, Andrew P. Lieberman, Xavier Salvatella
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Hsp chaperones stabilize the inactive conformation of androgen receptor (AR) and are released upon hormone-induced AR activation. Here, the authors locate the Hsp binding region on AR, and show that Hsp70 reduces AR aggregation and promotes AR degrad
Externí odkaz:
https://doaj.org/article/6c6c515e273b446cb66da2f55b7b3d95
Autor:
Marta Navarrete, María I. Cuartero, Rocío Palenzuela, Jonathan E. Draffin, Ainoa Konomi, Irene Serra, Sandra Colié, Sergio Castaño-Castaño, Mazahir T. Hasan, Ángel R. Nebreda, José A. Esteban
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
How astrocytes influence neuronal plasticity remains unclear, as they are typically considered as modulators of core mechanisms driven by neuronal components. Here, authors show that Long-term depression (LTD) induction in the hippocampus triggers ca
Externí odkaz:
https://doaj.org/article/64fbe2d448114949bc68acc5d6e2db61
Autor:
Raquel Batlle, Eva Andrés, Lorena Gonzalez, Elisabet Llonch, Ana Igea, Núria Gutierrez-Prat, Antoni Berenguer-Llergo, Angel R. Nebreda
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Mesenchymal cells contribute to tumor angiogenesis by regulating proliferation and migration of endothelial cells. Here, the authors show that mesenchymal stem cells also have the ability to acquire an endothelial phenotype upon TGF-β stimulation vi
Externí odkaz:
https://doaj.org/article/0ff11edc0a29452baa3d2896b959e5c3
P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim
Autor:
Ping Hu, Angel R. Nebreda, Helmut Hanenberg, Garrett H. Kinnebrew, Mircea Ivan, Mervin C. Yoder, Marie-Dominique Filippi, Hal E. Broxmeyer, Reuben Kapur
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Erythropoietin (EPO) stimulates erythropoiesis and is commonly used to treat anemia. Here Hu et al. find that P38α/JNK signaling restrains erythropoiesis independently of EPO by regulating epigenetic silencing of the proapoptotic protein Bim, and th
Externí odkaz:
https://doaj.org/article/83c7d281d7c544558201dc263cf809c2
Autor:
Catrin Youssif, Monica Cubillos‐Rojas, Mònica Comalada, Elisabeth Llonch, Cristian Perna, Nabil Djouder, Angel R Nebreda
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 7, Pp 1-20 (2018)
Abstract The protein kinase p38α plays a key role in cell homeostasis, and p38α signaling in intestinal epithelial cells protects against colitis‐induced tumorigenesis. However, little is known on the contribution of p38α signaling in intestinal
Externí odkaz:
https://doaj.org/article/84cdac96456f47bdb679fd6db6121f23
Autor:
Salvador Pérez, Sergio Rius-Pérez, Ana M. Tormos, Isabela Finamor, Ángel R. Nebreda, Raquel Taléns-Visconti, Juan Sastre
Publikováno v:
Redox Biology, Vol 16, Iss , Pp 276-284 (2018)
p38α is a redox sensitive MAPK activated by pro-inflammatory cytokines and environmental, genotoxic and endoplasmic reticulum stresses. The aim of this work was to assess whether p38α controls the antioxidant defense in the liver, and if so, to elu
Externí odkaz:
https://doaj.org/article/af101cae690c4f3fbbb762e9e4f8d37b