Zobrazeno 1 - 10 of 13 pro vyhledávání: '"A R Lussow"'
1
TARGETING OF ANTIHAPTEN ANTIBODIES TO ACTIVATED T CELLS VIA AN IL-2-HAPTEN CONJUGATE PROLONGS CARDIAC GRAFT SURVIVAL1
Autor: Philippe Pouletty, Roland Buelow, Alexander R. Lussow, Laurent Fanget, Lan Gao, Matthew S. Block
Publikováno v: Transplantation. 62:1703-1708
Antihapten antibodies binding to ligand-hapten conjugates are able to mediate complement mediated lysis in vitro. Based on this observation we propose a new in vivo immunotherapy using molecules that combine a low molecular weight hapten binding to a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::126562dcb42248e5edcf1f4da3f09c14
https://doi.org/10.1097/00007890-199612270-00001
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2
Redirecting Circulating Antibodies via Ligand-Hapten Conjugates Eliminates Target Cells In Vivo
Autor: L. Fanget, Gao L, S Peretto, A R Lussow, Buelow R, P Pouletty
Publikováno v: Journal of Immunotherapy. 19:257-265
The elimination of cell populations in vivo often relies on reagents that are self-limiting, are difficult to design and produce or contain highly toxic components. Here we describe a novel immunotherapy using molecules that combine a cell-specific l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881b83fddcce4a7c8f0d0ec1a8cbf21a
https://doi.org/10.1097/00002371-199607000-00002
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3
Differential effects of superantigen-induced 'anergy' on priming and effector stages of a T cell-dependent antibody response
Autor: H. Robson MacDonald, A R Lussow
Publikováno v: European Journal of Immunology. 24:445-449
The in vitro T cell nonresponsiveness or anergy to restimulation with staphylococcal enterotoxin B (SEB) following the in vivo injection of the superantigen is well characterized. Here we use mice transgenic for a V beta 8.2+ T cell receptor (TcR) (r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb64414f265ad24f2ebe9e36929e443
https://doi.org/10.1002/eji.1830240227
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5
Skewed T cell receptor Vα repertoire among superantigen reactive murine T cells
Autor: H. Robson MacDonald, A R Lussow, Gary A. Waanders
Publikováno v: International Immunology. 5:55-61
Reactivity of murine T cells with viral or bacterial superantigens is clearly correlated with the expression of TCR V beta domains. Thus, T cells responding to the minor lymphocyte stimulatory locus (Mls-1a) or staphylococcal enterotoxin B (SEB) expr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2123c3dce72a0bb04191abacfe57bde3
https://doi.org/10.1093/intimm/5.1.55
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6
Mycobacterial heat-shock proteins as carrier molecules. II: The use of the 70-kDa mycobacterial heat-shock protein as carrier for conjugated vaccinescan circumvent the need for adjuvants and Bacillus Calmette Guérin priming)
Autor: Paolo Costantino, Rino Rappuoli, Paul-Henri Lambert, Jan D. A. Van Embden, Jacques A. Louis, Ruurd Van Der Zee, Alexander R. Lussow, Christy Barrios, Giuseppe Del Giudice
Publikováno v: European Journal of Immunology. 22:1365-1372
In a recent work, we have shown that mycobacterial heat-shock proteins (hsp) of 65-kDa (GroEL-type) and 70-kDa (DnaK-type) acted as carrier molecules in mice, previously primed with Mycobacterium tuberculosis var. bovis (bacillus Calmette-Guérin, BC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ebf8ccbf4299364cb8394ad3de248bb
https://doi.org/10.1002/eji.1830220606
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7
Towards vaccine optimisation
Autor: A R Lussow, G. Del Giudice, Paul-Henri Lambert, M. T. Aguado
Publikováno v: Immunology Letters. 25:255-263
New molecular technologies have accelerated the search for sub-unit candidate vaccines. However, once identified the use of a candidate antigen must be optimised to reap the maximum benefit from the eventual vaccine. This optimisation should take int
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28dd16bd636b3d614c295cffe4267a53
https://doi.org/10.1016/0165-2478(90)90124-9
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8
Use of a tuberculin purified protein derivative--Asn-Ala-Asn-Pro conjugate in bacillus Calmette-Guérin primed mice overcomes H-2 restriction of the antibody response and avoids the need for adjuvants
Autor: L Rénia, A S Verdini, J P Verhave, A R Lussow, D Mazier, Paul-Henri Lambert, Pessi A, J A Louis, G. Del Giudice
Publikováno v: Proceedings of the National Academy of Sciences. 87:2960-2964
Because of its immunodominancy, and because it is conserved in different geographical isolates of Plasmodium falciparum, the repetitive sequence of the circumsporozoite protein, (Asn-Ala-Asn-Pro)n [(NANP)n], has been envisaged for the development of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3210c17a77081cc2a83a0999fd0ded
https://doi.org/10.1073/pnas.87.8.2960
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9
Targeting of antihapten antibodies to activated T cells via an IL-2-hapten conjugate prolongs cardiac graft survival
Autor: A R, Lussow, L, Fanget, L, Gao, M, Block, R, Buelow, P, Pouletty
Publikováno v: Transplantation. 62(12)
Antihapten antibodies binding to ligand-hapten conjugates are able to mediate complement mediated lysis in vitro. Based on this observation we propose a new in vivo immunotherapy using molecules that combine a low molecular weight hapten binding to a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::883f805f3fbb1ce7e734852fbe6022f9
https://pubmed.ncbi.nlm.nih.gov/8990347
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