Zobrazeno 1 - 10
of 146
pro vyhledávání: '"A R Blight"'
Autor:
Vieri Failli, Armin Curt, Michael G. Fehlings, Andrew R. Blight, Naomi Kleitman, Mark H. Tuszynski, Daniel P. Lammertse, James W. Fawcett, John D. Steeves, James D. Guest, Jane T.C. Hsieh
Publikováno v:
Top Spinal Cord Inj Rehabil
Experiencing a spinal cord injury (SCI) is extremely distressing, both physically and psychologically, and throws people into a complex, unfamiliar world of medical procedures, terminology, and decision making. You may have already had surgery to sta
Adaptive trial designs for spinal cord injury clinical trials directed to the central nervous system
Autor:
Linda Jones, Rϋediger Rupp, Andrew R. Blight, Daniel P. Lammertse, John L.K. Kramer, Frank W. Rockhold, John D. Steeves, James D. Guest, Steven Kirshblum, Mary Jane Mulcahey
Publikováno v:
Spinal Cord. 58:1235-1248
Narrative review. To provide an overview of adaptive trial designs, and describe how adaptive methods can address persistent challenges encountered by randomized controlled trials of people with spinal cord injury (SCI). With few exceptions, adaptive
Autor:
Ih Chang, Rachel Farrell, Jacob Elkins, Veronica Englishby, Jeremy Hobart, Manjit McNeill, Gabriel Paiva da Silva Lima, Raymond Hupperts, Peter Feys, Tjalf Ziemssen, Andrew D. Goodman, Andrew R. Blight, Michael Linnebank
Publikováno v:
CNS Drugs
Cns Drugs, 33(1), 61-79. Adis International Ltd
Cns Drugs, 33(1), 61-79. Adis International Ltd
Background Walking impairment is a hallmark of multiple sclerosis (MS). It affects > 90% of individuals over time, reducing independence and negatively impacting health-related quality of life, productivity, and daily activities. Walking impairment i
Autor:
Melissa L. Perreault, Rachel-Karson Thériault, Joshua D. Manduca, Jibran Y. Khokhar, Tariq A. Akhtar, Colin R Blight
Publikováno v:
Journal of psychopharmacology (Oxford, England). 34(7)
Background:Mitragynine is the major alkaloid of Mitragyna speciosa (kratom) with potential as a therapeutic in pain management and in depression. There has been debate over the potential side effects of the drug including addiction risk and cognitive
At first sight the 'tank of sand' provided by the Kopervik/Captain Sandstone Member reservoir of the Atlantic Field is a development geologist's and reservoir engineer's dream. However, the challenges posed are several: (1) The top of the reservoir i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340bd2df0469daa4bf4cf248cc222270
Autor:
Andrew R. Blight
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 4 (2011)
Potassium channel blockade has long been considered a potential therapeutic strategy for treatment of multiple sclerosis (MS) based on the pathophysiology of demyelinated axons. Dalfampridine, which is also known as fampridine or 4-aminopyridine (4-A
Externí odkaz:
https://doaj.org/article/3136278b3c154d97bdda2c625f93856c
Autor:
Armin Curt, John D. Steeves, R Reed, R Rupp, Daniel P. Lammertse, Andrew R. Blight, Norbert Weidner, S. C. Kirshblum, Linda Jones, Rainer Abel, Mandeep R. Mehra, Doris Maier
Publikováno v:
Spinal Cord. 55:730-738
Retrospective statistical analysis of database. Spinal cord injury (SCI) clinical trials are challenged to enroll participants, and early trial outcomes have often been equivocal. We hypothesized that a specifically designed novel true linear interva
Autor:
Rod Moseanko, Leif A. Havton, Ernesto A. Salegio, Mark H. Tuszynski, James W. Fawcett, Adam R. Ferguson, Janet L. Weber, Jennifer Iaci, Stephanie Hawbecker, J. Russell Huie, Yvette S. Nout-Lomas, Barbara Haenzi, John H. Brock, Roger Pender, Jacqueline C. Bresnahan, Michael S. Beattie, Andrew R. Blight, Chase A. Weinholtz, Ephron S. Rosenzweig, Christina Cruzen, Justine J. Liang, Anthony O. Caggiano
Publikováno v:
Nature neuroscience, vol 22, iss 8
Nature neuroscience
Nature neuroscience
Inhibitory extracellular matrices form around mature neurons as perineuronal nets containing chondroitin sulfate proteoglycans that limit axonal sprouting after CNS injury. The enzyme chondroitinase (Chase) degrades inhibitory chondroitin sulfate pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8634f8d08ce496622c66fd92d80d94be
https://escholarship.org/uc/item/1n72g749
https://escholarship.org/uc/item/1n72g749
Autor:
Brian K. Kwon, Armin Curt, Andrew R. Blight, Naomi Kleitman, Shekar N. Kurpad, Jane Hsieh, John D. Steeves, James D. Guest, James W. Fawcett, Norbert Weidner, Daniel P. Lammertse
STUDY DESIGN: Narrative review by individuals experienced in the recruitment of participants to neurotherapeutic clinical trials in spinal cord injury (SCI). OBJECTIVES: To identify key problems of recruitment and explore potential approaches to over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0fb0646a96e8f2eab17098280472e55
https://www.repository.cam.ac.uk/handle/1810/295308
https://www.repository.cam.ac.uk/handle/1810/295308
Autor:
Steven Kirshblum, Rainer Abel, Daniel P. Lammertse, John D. Steeves, Doris Maier, Armin Curt, Norbert Weidner, Rüdiger Rupp, Andrew R. Blight, Munish Mehra, Linda Jones
Publikováno v:
Spinal cord. 56(5)