Zobrazeno 1 - 10
of 501
pro vyhledávání: '"A R, Zlotta"'
Autor:
Jethro C. C. Kwong, Jeremy Wu, Shamir Malik, Adree Khondker, Naveen Gupta, Nicole Bodnariuc, Krishnateja Narayana, Mikail Malik, Theodorus H. van der Kwast, Alistair E. W. Johnson, Alexandre R. Zlotta, Girish S. Kulkarni
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Accurate prediction of recurrence and progression in non-muscle invasive bladder cancer (NMIBC) is essential to inform management and eligibility for clinical trials. Despite substantial interest in developing artificial intelligence (AI) ap
Externí odkaz:
https://doaj.org/article/30b7b1ffba8f4f0db8849c53dde71700
Autor:
Inmaculada Navarro-Domenech, Shinthujah Arulanantham, Zhihui Amy Liu, Michael Tjong, Vickie Kong, Victor Malkov, Tony Tadic, Neil Fleshner, Girish Kulkarni, Alexandre R Zlotta, Charles Catton, Alejandro Berlin, Srikala Sridhar, Di (Maria) Jiang, Peter Chung, Srinivas Raman
Publikováno v:
Radiation Oncology, Vol 18, Iss 1, Pp 1-9 (2023)
Abstract Purpose/Objective Definitive radiotherapy (RT) is an alternative to radical cystectomy for select patients with muscle invasive bladder cancer (MIBC); however, there is limited data on dose-painted RT approaches. We report the clinical and d
Externí odkaz:
https://doaj.org/article/8bf9fb25c3c74dcba7e6fd06a9628546
Autor:
Jethro C C Kwong, MD, Adree Khondker, BHSc, Eric Meng, BSc, Nicholas Taylor, BSc, Cynthia Kuk, MSc, Nathan Perlis, MD, Girish S Kulkarni, ProfMD, Robert J Hamilton, MD, Neil E Fleshner, ProfMD, Antonio Finelli, ProfMD, Theodorus H van der Kwast, ProfMD, Amna Ali, BSc, Munir Jamal, MD, Frank Papanikolaou, MD, Thomas Short, MD, John R Srigley, ProfMD, Valentin Colinet, MD, Alexandre Peltier, ProfMD, Romain Diamand, MD, Yolene Lefebvre, MD, Qusay Mandoorah, MD, Rafael Sanchez-Salas, MD, Petr Macek, MD, Xavier Cathelineau, ProfMD, Martin Eklund, ProfPhD, Alistair E W Johnson, DPhil, Andrew Feifer, MD, Alexandre R Zlotta, ProfMD
Publikováno v:
The Lancet: Digital Health, Vol 5, Iss 7, Pp e435-e445 (2023)
Summary: Background: Accurate prediction of side-specific extraprostatic extension (ssEPE) is essential for performing nerve-sparing surgery to mitigate treatment-related side-effects such as impotence and incontinence in patients with localised pros
Externí odkaz:
https://doaj.org/article/9e48ab8efa664112a1f3da359fa83dba
Autor:
Michael Fraser, Julie Livingstone, Jeffrey L. Wrana, Antonio Finelli, Housheng Hansen He, Theodorus van der Kwast, Alexandre R. Zlotta, Robert G. Bristow, Paul C. Boutros
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Biomarkers of prostate cancer metastasis have been difficult to determine with confidence. Here the authors analyse mutation prevalence in 1844 prostate cancers and show that ZNRF3 loss is enriched in metastatic, castration-resistant prostate cancer
Externí odkaz:
https://doaj.org/article/5be08d8b8b2e4398b9561e54a4056765
Autor:
Esmail M. Al‐Ezzi, Husam A. Alqaisi, Marco A. J. Iafolla, Lisa Wang, Srikala S. Sridhar, Adrian G. Sacher, Nazanin Fallah‐Rad, Di M. Jiang, Geoffrey A. Watson, Charles N. Catton, Padraig R. Warde, Rob J. Hamilton, Neil E. Fleshner, Alexandre R. Zlotta, Aaron R. Hansen
Publikováno v:
Cancer Medicine, Vol 10, Iss 17, Pp 5775-5782 (2021)
Abstract Background In men with metastatic castration‐resistant prostate cancer (mCRPC) with primarily bone metastases, radium‐223 (223Ra) improves overall survival (OS). However, the selection of 223Ra is not guided by specific validated clinico
Externí odkaz:
https://doaj.org/article/da392819a41c4b0387329a1e9a5afd5b
Autor:
Kenneth Wenger, Kayvan Tirdad, Alex Dela Cruz, Andrea Mari, Mayada Basheer, Cynthia Kuk, Bas W.G. van Rhijn, Alexandre R. Zlotta, Theodorus H. van der Kwast, Alireza Sadeghian
Publikováno v:
Machine Learning with Applications, Vol 9, Iss , Pp 100347- (2022)
Recent advances in semi-supervised learning algorithms (SSL) have made great strides in reducing the training dependency on labeled datasets and requiring that only a subset of the data be labeled. The presented work explores a class of semi-supervis
Externí odkaz:
https://doaj.org/article/5cc4f0b5b9084cd097e951809ec524a1
Autor:
Khashayar Habibi, Kayvan Tirdad, Alex Dela Cruz, Kenneth Wenger, Andrea Mari, Mayada Basheer, Cynthia Kuk, Bas W.G. van Rhijn, Alexandre R. Zlotta, Theodorus H. van der Kwast, Alireza Sadeghian
Publikováno v:
Machine Learning with Applications, Vol 9, Iss , Pp 100387- (2022)
Bladder cancer tissue grading, which assigns a numerical grade reflecting how aggressive a tumor looks under a microscope, is essential to determine the proper course of treatment, design a therapeutic plan and determine prognosis. The major problem
Externí odkaz:
https://doaj.org/article/612fbab594ae42f0bcf7ae6a866e79c4
Autor:
Otto Hemminki, Nathan Perlis, Johan Bjorklund, Antonio Finelli, Alexandre R. Zlotta, Akseli Hemminki
Publikováno v:
European Urology Open Science, Vol 22, Iss , Pp 61-73 (2020)
Context: Current guidelines suggest several targeted therapies (TTs) and immunotherapies (ITs) in the treatment of advanced or metastatic renal cell carcinoma (mRCC). Ideal sequencing of these treatments is unclear. Objective: The primary objective w
Externí odkaz:
https://doaj.org/article/22ad140018e9439484414c852cfcdb92
Autor:
Alexandre R Zlotta, Leslie K Ballas, Andrzej Niemierko, Katherine Lajkosz, Cynthia Kuk, Gus Miranda, Michael Drumm, Andrea Mari, Ethan Thio, Neil E Fleshner, Girish S Kulkarni, Michael A S Jewett, Robert G Bristow, Charles Catton, Alejandro Berlin, Srikala S Sridhar, Anne Schuckman, Adam S Feldman, Matthew Wszolek, Douglas M Dahl, Richard J Lee, Philip J Saylor, M Dror Michaelson, David T Miyamoto, Anthony Zietman, William Shipley, Peter Chung, Siamak Daneshmand, Jason A Efstathiou
Publikováno v:
The Lancet Oncology. 24:669-681
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ede86cf60220991306b99706c1eddde
https://doi.org/10.1016/s1470-2045(23)00170-5
https://doi.org/10.1016/s1470-2045(23)00170-5
Autor:
Shivani Kamdar, Ruth Isserlin, Theodorus Van der Kwast, Alexandre R. Zlotta, Gary D. Bader, Neil E. Fleshner, Bharati Bapat
Publikováno v:
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-19 (2019)
Abstract Background Global DNA methylation alterations are hallmarks of cancer. The tumor-suppressive TET enzymes, which are involved in DNA demethylation, are decreased in prostate cancer (PCa); in particular, TET2 is specifically targeted by androg
Externí odkaz:
https://doaj.org/article/e6d4dc82c3a047528c0b7b4c702f08f0