Výsledky vyhledávání - "A R, Whiting"

Akademický článek

CRISPR-Cas9 correction of a nonsense mutation in LCA5 rescues lebercilin expression and localization in human retinal organoids

Autor: Tess A.V. Afanasyeva, Dimitra Athanasiou, Pedro R.L. Perdigao, Kae R. Whiting, Lonneke Duijkers, Galuh D.N. Astuti, Jean Bennett, Alejandro Garanto, Jacqueline van der Spuy, Ronald Roepman, Michael E. Cheetham, Rob W.J. Collin

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 522-531 (2023)

Mutations in the lebercilin-encoding gene LCA5 cause one of the most severe forms of Leber congenital amaurosis, an early-onset retinal disease that results in severe visual impairment. Here, we report on the generation of a patient-specific cellular

Externí odkaz: https://doaj.org/article/638b92cd785044729f1ee8d162702be3

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Akademický článek

SNP discovery and genetic structure in blue mussel species using low coverage sequencing and a medium density 60 K SNP‐array

Autor: Jennifer C. Nascimento‐Schulze, Tim P. Bean, Carolina Peñaloza, Josephine R. Paris, James R. Whiting, Alexis Simon, Bonnie A. Fraser, Ross D. Houston, Nicolas Bierne, Robert P. Ellis

Publikováno v: Evolutionary Applications, Vol 16, Iss 5, Pp 1044-1060 (2023)

Abstract Blue mussels from the genus Mytilus are an abundant component of the benthic community, found in the high latitude habitats. These foundation species are relevant to the aquaculture industry, with over 2 million tonnes produced globally each

Externí odkaz: https://doaj.org/article/0e91656d7b4b4d42b28e228603421bf7

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Akademický článek

Rapid genomic convergent evolution in experimental populations of Trinidadian guppies (Poecilia reticulata)

Autor: Mijke J. van derZee, James R. Whiting, Josephine R. Paris, Ron D. Bassar, Joseph Travis, Detlef Weigel, David N. Reznick, Bonnie A. Fraser

Publikováno v: Evolution Letters, Vol 6, Iss 2, Pp 149-161 (2022)

Abstract Although rapid phenotypic evolution has been documented often, the genomic basis of rapid adaptation to natural environments is largely unknown in multicellular organisms. Population genomic studies of experimental populations of Trinidadian

Externí odkaz: https://doaj.org/article/75e0dd0f38cc471f8670b322d1fcc8bb

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Akademický článek

A large and diverse autosomal haplotype is associated with sex-linked colour polymorphism in the guppy

Autor: Josephine R. Paris, James R. Whiting, Mitchel J. Daniel, Joan Ferrer Obiol, Paul J. Parsons, Mijke J. van der Zee, Christopher W. Wheat, Kimberly A. Hughes, Bonnie A. Fraser

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Extreme colour pattern variation in male Trinidadian guppies are influenced by natural selection and sexual selection. Here, the authors phenotype and genotype four guppy lineages finding that colour pattern is associated with a diverse haplotype on

Externí odkaz: https://doaj.org/article/47509e412add4f8fbcd0da679fa70d0e

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