Zobrazeno 1 - 10
of 39
pro vyhledávání: '"A R, Stainer"'
Autor:
Kahdr A. Alatawi, Divyashree Ravishankar, Pabitra H. Patra, Alexander P. Bye, Alexander R. Stainer, Ketan Patel, Darius Widera, Sakthivel Vaiyapuri
Publikováno v:
Cells, Vol 10, Iss 10, p 2616 (2021)
1,8-cineole, a monoterpenoid is a major component of eucalyptus oil and has been proven to possess numerous beneficial effects in humans. Notably, 1,8-cineole is the primary active ingredient of a clinically approved drug, Soledum® which is being ma
Externí odkaz:
https://doaj.org/article/82d76c7a081249898cf98ac2961d52fd
Autor:
Alexander R. Stainer, Parvathy Sasikumar, Alexander P. Bye, Amanda J. Unsworth, Lisa M. Holbrook, Marcus Tindall, Julie A. Lovegrove, Jonathan M. Gibbins
Publikováno v:
TH Open, Vol 03, Iss 03, Pp e244-e258 (2019)
Quercetin, a dietary flavonoid, has been reported to possess antiplatelet activity. However, its extensive metabolism following ingestion has resulted in difficulty elucidating precise mechanisms of action. In this study, we aimed to characterize the
Externí odkaz:
https://doaj.org/article/01cb12021d2649e0b0fa8c7994e0003d
Autor:
Julie A. Lovegrove, Amanda J. Unsworth, Parvathy Sasikumar, Alexander R. Stainer, Alexander P. Bye, Marcus J. Tindall, Lisa M. Holbrook, Jonathan M. Gibbins
Publikováno v:
TH Open, Vol 03, Iss 03, Pp e244-e258 (2019)
TH Open: Companion Journal to Thrombosis and Haemostasis
TH Open: Companion Journal to Thrombosis and Haemostasis
Quercetin, a dietary flavonoid, has been reported to possess antiplatelet activity. However, its extensive metabolism following ingestion has resulted in difficulty elucidating precise mechanisms of action. In this study, we aimed to characterize the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd389f9afdf9f89857140395848e8e04
https://doi.org/10.1055/s-0039-1694028
https://doi.org/10.1055/s-0039-1694028
Autor:
Sarah Jones, Neline Kriek, James L Hutchinson, Renato Simões Gaspar, Hervé Falet, Alexander P. Bye, Peter J. Volberding, Stuart J. Mundell, Alexander R. Stainer, Caleb Drew, Nathan Eaton, Jonathan M. Gibbins, Tanya Sage, Weiguo Cui, Amanda J. Unsworth, Ryan Riley
Publikováno v:
Haematologica
Pim kinases are upregulated in several forms of cancer, contributing to cell survival and tumor development, but their role in platelet function and thrombotic disease has not been explored. We report for the first time that Pim-1 kinase is expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d413cd5ea4b844e9c38c4c05ae131b
https://e-space.mmu.ac.uk/625825/
https://e-space.mmu.ac.uk/625825/
Autor:
Neline Kriek, Recep Adiyaman, Sarah K. AlOuda, Sakthivel Vaiyapuri, Gagan D. Flora, Mohammad AboHassan, Chris I. Jones, Amro Elgheznawy, Amanda J. Unsworth, Alexander R. Stainer, Alexander P. Bye, Jonathan M. Gibbins, Ali H. A. Maghrabi, Lisa-Marie Holbrook, Tanya Sage, Liam J. McGuffin, Khaled A. Sahli, Marilena Crescente, Parvathy Sasikumar
Publikováno v:
Blood
Connexins oligomerise to form hexameric hemichannels in the plasma membrane that can further dock together on adjacent cells to form gap junctions and facilitate intercellular trafficking of molecules. In this study, we report the expression and func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c70797cc5e328d572812b333558d090
https://pubmed.ncbi.nlm.nih.gov/32822477
https://pubmed.ncbi.nlm.nih.gov/32822477
Autor:
Jonathan M. Gibbins, Tanya Sage, Lisa-Marie Holbrook, Amanda J. Unsworth, Gagan D. Flora, Parvathy Sasikumar, Alexander R. Stainer, Sarah K. AlOuda, Marilena Crescente, Khaled A. Sahli
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
The pregnane X receptor (PXR) is a nuclear receptor (NR), involved in the detoxification of xenobiotic compounds. Recently, its presence was reported in the human vasculature and its ligands were proposed to exhibit anti-atherosclerotic effects. Sinc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed54bfde27214bca182e7547ad708c3d
https://pubmed.ncbi.nlm.nih.gov/31748641
https://pubmed.ncbi.nlm.nih.gov/31748641
Autor:
Rekha Rana, Jonathan M. Gibbins, Michael P. Schenk, Tanya Sage, Marfoua S. Ali, Neline Kriek, Amanda J. Unsworth, Alexander R. Stainer, Leonardo A. Moraes, Chris I. Jones, Sakthivel Vaiyapuri
Publikováno v:
Blood. 125:720-730
The Eph kinases, EphA4 and EphB1, and their ligand, ephrinB1, have been previously reported to be present in platelets where they contribute to thrombus stability. Although thrombus formation allows for Eph-ephrin engagement and bidirectional signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d71aa2a0310cbf9b78153b3dd51cd61
https://doi.org/10.1182/blood-2014-06-585083
https://doi.org/10.1182/blood-2014-06-585083
Publikováno v:
Acta Horticulturae. :339-346
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1085c85e26b9f9c146a8b2058bd4cf67
https://doi.org/10.17660/actahortic.2013.984.41
https://doi.org/10.17660/actahortic.2013.984.41
Autor:
L-M, Holbrook, G K, Sandhar, P, Sasikumar, M P, Schenk, A R, Stainer, K A, Sahli, G D, Flora, A B, Bicknell, J M, Gibbins
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 16(2)
Essentials ERp72 is a thiol isomerase enzyme. ERp72 levels increase at the platelet surface during platelet activation. We generated a humanized monoclonal antibody which blocks ERp72 enzyme activity (anti-ERp72). Anti-ERp72 inhibits platelet functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d0f4d9d7ce0a8f85c302e3374e8f1f3
https://pubmed.ncbi.nlm.nih.gov/29194946
https://pubmed.ncbi.nlm.nih.gov/29194946
Autor:
Amanda J. Unsworth, Alexander R. Stainer, Michael J. Fry, Alexander P. Bye, Jonathan M. Gibbins, Sakthivel Vaiyapuri
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 35(11)
Objective— Ibrutinib is an irreversible Bruton tyrosine kinase inhibitor approved for treatment of Waldenstrom macroglobulinemia, chronic lymphocytic leukemia, and mantle cell lymphoma that increases the risk of bleeding among patients. Platelets f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c666c6f588acc45c56f8eec3ecd763
https://pubmed.ncbi.nlm.nih.gov/26359510
https://pubmed.ncbi.nlm.nih.gov/26359510