Zobrazeno 1 - 10
of 176
pro vyhledávání: '"A R, Renslo"'
Autor:
Tesfahun Dessale Admasu, Kristie Kim, Michael Rae, Roberto Avelar, Ryan L. Gonciarz, Abdelhadi Rebbaa, João Pedro de Magalhães, Adam R. Renslo, Alexandra Stolzing, Amit Sharma
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112058- (2023)
Summary: Senescent cells can spread the senescent phenotype to other cells by secreting senescence-associated secretory phenotype factors. The resulting paracrine senescent cells make a significant contribution to the burden of senescent cell accumul
Externí odkaz:
https://doaj.org/article/1dbc15388e3a4d6f973381989097447d
Autor:
Gha-Hyun J Kim, Han Mo, Harrison Liu, Zhihao Wu, Steven Chen, Jiashun Zheng, Xiang Zhao, Daryl Nucum, James Shortland, Longping Peng, Mannuel Elepano, Benjamin Tang, Steven Olson, Nick Paras, Hao Li, Adam R Renslo, Michelle R Arkin, Bo Huang, Bingwei Lu, Marina Sirota, Su Guo
Publikováno v:
eLife, Vol 10 (2021)
Parkinson’s disease (PD) is a common neurodegenerative disorder without effective disease-modifying therapeutics. Here, we establish a chemogenetic dopamine (DA) neuron ablation model in larval zebrafish with mitochondrial dysfunction and robustnes
Externí odkaz:
https://doaj.org/article/1a2b18fbbd014e52b754a5691eee90b7
Autor:
Ryan K. Muir, Ning Zhao, Junnian Wei, Yung-hua Wang, Anna Moroz, Yangjie Huang, Ying-Chu Chen, Renuka Sriram, John Kurhanewicz, Davide Ruggero, Adam R. Renslo, Michael J. Evans
Publikováno v:
ACS Central Science, Vol 5, Iss 4, Pp 727-736 (2019)
Externí odkaz:
https://doaj.org/article/8a1f8dc0392b4f1ca4cc2864af7b7b4e
Autor:
Kurt S. Van Horn, Dongju Wang, Daniel Medina-Cleghorn, Peter S. Lee, Clifford Bryant, Chad Altobelli, Priyadarshini Jaishankar, Kevin K. Leung, Raymond A. Ng, Andrew J. Ambrose, Yinyan Tang, Michelle R. Arkin, Adam R. Renslo
Publikováno v:
Journal of the American Chemical Society, vol 145, iss 18
Caspases are a family of cysteine-dependent proteases with important cellular functions in inflammation and apoptosis, while also implicated in human diseases. Classical chemical tools to study caspase functions lack selectivity for specific caspase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2313ac4d40ba23573c730af3ed6f119
https://doi.org/10.1021/jacs.2c12240
https://doi.org/10.1021/jacs.2c12240
Publikováno v:
ACS Medicinal Chemistry Letters. 14:493-498
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91f90990f3c21dcdbfde774f06624954
https://doi.org/10.1021/acsmedchemlett.3c00039
https://doi.org/10.1021/acsmedchemlett.3c00039
Autor:
Emma L. Gunderson, Clifford Bryant, Christina A. Bulman, Chelsea Fischer, Mona Luo, Ian Vogel, Kee-Chong Lim, Shabnam Jawahar, Nancy Tricoche, Denis Voronin, Christopher Corbo, Rene B. Ayiseh, Faustin P. T. Manfo, Glory E. Mbah, Fidelis Cho-Ngwa, Brenda Beerntsen, Adam R. Renslo, Sara Lustigman, Judy A. Sakanari
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 189 (2022)
Onchocerciasis and lymphatic filariasis are neglected tropical diseases caused by infection with filarial worms. Annual or biannual mass drug administration with microfilaricidal drugs that kill the microfilarial stages of the parasites has helped re
Externí odkaz:
https://doaj.org/article/47f08033f00a440f8fc6a2eb661e1414
Autor:
Michael D. Sacco, Kyle Defrees, Xiujun Zhang, William Lawless, Emeka Nwanochie, Amelia Balsizer, Sophie E. Darch, Adam R. Renslo, Yu Chen
Publikováno v:
ACS Infectious Diseases. 8:1231-1240
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebd16bd47f4ccf522664113f495b1eee
https://doi.org/10.1021/acsinfecdis.1c00650
https://doi.org/10.1021/acsinfecdis.1c00650
Autor:
Stefan Gahbauer, Galen J. Correy, Marion Schuller, Matteo P. Ferla, Yagmur Umay Doruk, Moira Rachman, Taiasean Wu, Morgan Diolaiti, Siyi Wang, R. Jeffrey Neitz, Daren Fearon, Dmytro Radchenko, Yurii Moroz, John J. Irwin, Adam R. Renslo, Jenny C. Taylor, Jason E. Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K. Shoichet, James S. Fraser
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 120, iss 2
The nonstructural protein 3 (NSP3) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains a conserved macrodomain enzyme (Mac1) that is critical for pathogenesis and lethality. While small molecule inhibitors of Mac1 have great
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991faf3ec537a19849a09bb30d7edb38
https://pubmed.ncbi.nlm.nih.gov/36598939
https://pubmed.ncbi.nlm.nih.gov/36598939
Autor:
Yu Chen, Adam R. Renslo, M. Trent Kemp, Insung Na, Xiujun Zhang, Kyle DeFrees, Derek A. Nichols
Publikováno v:
FEBS Letters. 595:2981-2994
The Asp233-Asp246 pair is highly conserved in Class A β-lactamases, which hydrolyze β-lactam antibiotics. Here, we characterize its function using CTX-M-14 β-lactamase. The D233N mutant displayed decreased activity that is substrate-dependent, wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b7dcd70f060259df6f6764a170cf260
https://doi.org/10.1002/1873-3468.14215
https://doi.org/10.1002/1873-3468.14215
Autor:
Vladimir Camarena, David W Sant, Tyler C Huff, Sushmita Mustafi, Ryan K Muir, Allegra T Aron, Christopher J Chang, Adam R Renslo, Paula V Monje, Gaofeng Wang
Publikováno v:
eLife, Vol 6 (2017)
It is widely accepted that cAMP regulates gene transcription principally by activating the protein kinase A (PKA)-targeted transcription factors. Here, we show that cAMP enhances the generation of 5-hydroxymethylcytosine (5hmC) in multiple cell types
Externí odkaz:
https://doaj.org/article/cb740e3e9cd14769a9739af54a035d72