Zobrazeno 1 - 10
of 25
pro vyhledávání: '"A R, Mukhitov"'
Autor:
Kathryn M. Rubey, Alexander R. Mukhitov, Jia Nong, Jichuan Wu, Vera P. Krymskaya, Jacob W. Myerson, G. Scott Worthen, Jacob S. Brenner
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Despite the power of antibiotics, bacterial infections remain a major killer, due to antibiotic resistance and hosts with dysregulated immune systems. We and others have been developing drug-loaded nanoparticles that home to the sites of infection an
Externí odkaz:
https://doaj.org/article/e813c9186b2f4af98701330fc592cef8
Autor:
Kseniya Obraztsova, Maria C. Basil, Ryan Rue, Aravind Sivakumar, Susan M. Lin, Alexander R. Mukhitov, Andrei I. Gritsiuta, Jilly F. Evans, Meghan Kopp, Jeremy Katzen, Annette Robichaud, Elena N. Atochina-Vasserman, Shanru Li, Justine Carl, Apoorva Babu, Michael P. Morley, Edward Cantu, Michael F. Beers, David B. Frank, Edward E. Morrisey, Vera P. Krymskaya
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The cellular origins of lymphangioleiomyomatosis (LAM), a rare fatal lung disease, are poorly understood. Here the authors identify a mesenchymal cell hub coordinating the LAM phenotype and develop a LAM mouse model where they investigate the co-oper
Externí odkaz:
https://doaj.org/article/920f2bde4ce048d5a6bf73943fc2fe6e
Autor:
Jilly F. Evans, Ryan W. Rue, Alexander R. Mukhitov, Kseniya Obraztsova, Carly J. Smith, Vera P. Krymskaya
Publikováno v:
Biomolecules, Vol 10, Iss 1, p 28 (2019)
Lymphangioleiomyomatosis (LAM) is a rare metastatic cystic lung disease due to a mutation in a TSC tumor suppressor, resulting in hyperactive mTOR growth pathways. Sirolimus (rapamycin), an allosteric mTORC1 inhibitor, is a therapeutic option for wom
Externí odkaz:
https://doaj.org/article/b40ff0dd99e24b9e81de04578169971c
Autor:
Susan M. Lin, Ryan Rue, Akansha Goel, Kseniya Obraztsova, Alexander R. Mukhitov, Kanth Swaroop Vanka, Carly J. Smith, Maria C. Basil, Laura T. Ferguson, Joseph D. Planer, Edward Cantu, Grazyna Kwapiszewska, Edward E. Morrisey, Jillian F. Evans, Vera P. Krymskaya
Pulmonary vascular remodeling is the key structural abnormality in pulmonary hypertension (PH). Mechanistic target of rapamycin (mTOR) has long been suspected to play a role in the development of pulmonary vascular remodeling. However, underlying cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da666a5cd4a35e3f11b5da871f4e9bda
https://doi.org/10.1101/2022.10.08.511300
https://doi.org/10.1101/2022.10.08.511300
Autor:
Maria C. Basil, Susan M. Lin, Jilly F. Evans, Edward E. Morrisey, Justine Carl, Aravind Sivakumar, Ryan Rue, Shanru Li, Michael Morley, Andrei I. Gritsiuta, Kseniya Obraztsova, Jeremy Katzen, David B. Frank, Edward Cantu, Annette Robichaud, Vera P. Krymskaya, Apoorva Babu, Alexander R. Mukhitov, Elena N. Atochina-Vasserman, Michael F. Beers, Meghan Kopp
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Lymphangioleiomyomatosis (LAM) is a rare fatal cystic lung disease due to bi-allelic inactivating mutations in tuberous sclerosis complex (TSC1/TSC2) genes coding for suppressors of the mechanistic target of rapamycin complex 1 (mTORC1). The origin o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784a60204bfcbda037281131ba09847c
http://link.springer.com/article/10.1038/s41467-020-18979-4
http://link.springer.com/article/10.1038/s41467-020-18979-4
Autor:
Vadim V. Salnikov, Elmira A. Vasilieva, Alla B. Mirgorodskaya, Shamil K. Latypov, Dinar R. Gabdrakhmanov, Victor V. Syakaev, Farida G. Valeeva, Darya A. Kuznetsova, Svetlana S. Lukashenko, Mikhail A. Voronin, Lucia Ya. Zakharova, Yuriy F. Zuev, Alexander R. Mukhitov, Valery M. Zakharov, Dzhigangir A. Faizullin
Publikováno v:
The Journal of Physical Chemistry C. 124:2178-2192
Self-organization of hydroxyethylated gemini surfactants with different spacer fragments 16-s-16(OH) (s = 4, 6, 10, and 12) was studied in single solutions and in binary surfactant-oligonucleotide systems. Despite the fact that aggregation activity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95c2d2a5daadb2250dce88097aeb7117
https://doi.org/10.1021/acs.jpcc.9b10079
https://doi.org/10.1021/acs.jpcc.9b10079
Autor:
Chandrasekaran Nagaswami, Khalil Bdeir, Alexander R. Mukhitov, Mohamed Higazi, Abd Al-Roof Higazi, Emad Maraga, John W. Weisel, Rustem I. Litvinov, Suhair Abdeen, Rami Abu-Fanne, Douglas B. Cines, Victoria Stepanova
Publikováno v:
Blood. 133:481-493
Inflammation and thrombosis are integrated, mutually reinforcing processes, but the interregulatory mechanisms are incompletely defined. Here, we examined the contribution of α-defensins (α-defs), antimicrobial proteins released from activated huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e6964ca10f7da42fc616c2e98346bf2
https://doi.org/10.1182/blood-2018-07-861237
https://doi.org/10.1182/blood-2018-07-861237
Autor:
Lars Giebeler, Konstantin A. Petrov, Asiya R. Mustafina, Alexey Stepanov, Gusel V. Sibgatullina, Svetlana V. Fedorenko, Irek R. Nizameev, Mark H. Rümmeli, Thomas Gemming, Bruno Weise, Dmitry V. Samigullin, Kirill V. Kholin, Rafael G. Mendes, Alexander R. Mukhitov
Publikováno v:
Nanoscale. 11:16103-16113
This report introduces both synthesis and in vitro biological behaviour of dual magnetic-fluorescent silica nanoparticles. The amino group-decoration of 78 nm sized silica nanoparticles enables their efficient internalization into motoneurons, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fb30d726df6aff3797d746c7da305ee
https://doi.org/10.1039/c9nr05071j
https://doi.org/10.1039/c9nr05071j
Autor:
Irina V. Galkina, Gulnara A. Gaynanova, Elena A. Ermakova, Lucia Ya. Zakharova, Yuriy F. Zuev, Sergey V. Cheresiz, Polina V. Skvortsova, Alexander R. Mukhitov, Andrey G. Pokrovsky, Yuri Gogolev, Guzalia I. Kaupova, Dinar R. Gabdrakhmanov
Publikováno v:
Physical Chemistry Chemical Physics. 21:16706-16717
Herein, for the first time the complexation ability of a homological series of triphenylphosphonium surfactants (TPPB-n) toward DNA decamers has been explored. Formation of lipoplexes was confirmed by alternative techniques, including dynamic light s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aaf65d42ec9993710284d9f268d5508
https://doi.org/10.1039/c9cp02384d
https://doi.org/10.1039/c9cp02384d
Autor:
Vera P. Krymskaya, Ryan Rue, Kseniya Obraztsova, Jilly F. Evans, Carly J. Smith, Alexander R. Mukhitov
Publikováno v:
Biomolecules
Volume 10
Issue 1
Biomolecules, Vol 10, Iss 1, p 28 (2019)
Volume 10
Issue 1
Biomolecules, Vol 10, Iss 1, p 28 (2019)
Lymphangioleiomyomatosis (LAM) is a rare metastatic cystic lung disease due to a mutation in a TSC tumor suppressor, resulting in hyperactive mTOR growth pathways. Sirolimus (rapamycin), an allosteric mTORC1 inhibitor, is a therapeutic option for wom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f4431fad785d9b44bb49c73b72370a