Zobrazeno 1 - 10
of 20
pro vyhledávání: '"A R, Matzuk"'
Autor:
Wesley L. Shoop, John R. Egerton, Helmut Mrozik, P. Eskola, Maureen Tischler, Aino Lusi, Thomas L. Shih, Matthew J. Wyvratt, Michael H. Fisher, Timothy A. Blizzard, Gaye Margiatto, F. S. Waksmunski, Alexander R Matzuk, Bruce O. Linn, Byron H. Arison
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2435-2440
Reductive amination of 4″-oxo-5-O-tert-butyldimethylsilyl-avermectins with sodium cyanoborohydride and ammonium acetate gave an epimeric mixture of 4″-deoxy-4″-amino analogs with the epimeric, axial 4″-β-amino derivative as the major compone
Autor:
B. E. Witzel, W. V. Ruyle, Lewis H Sarett, J. Hannah, RW Houser, A. R. Matzuk, T. Y. Shen, H. Jones, W. J. Holtz, K. W. Kelly
Publikováno v:
British Journal of Clinical Pharmacology. 4:7S-13S
1 Diflunisal (MK-647; 5-(2,4-difluorophenyl)-salicylic acid) is a new analgesic anti-inflammatory agent discovered after an extensive chemical and pharmacological study from 1962-71. 2 In the search for a superior salicylate our objectives were highe
Autor:
J, Hannah, W V, Ruyle, H, Jones, A R, Matzuk, K W, Kelly, B E, Witzel, W J, Holtz, R A, Houser, T Y, Shen, L H, Sarett
Publikováno v:
Journal of Medicinal Chemistry. 21:1093-1100
5-(2,4-Difluorophenyl)salicylic acid, diflunisal (25), is the best compound, in terms of both efficacy and safety, from over 500 salicylates investigated in our laboratories. It is a chemically distinct, nonacetylating salicylic acid, more active tha
Autor:
Helmut Mrozik, Aino Lusi, Michael H. Fisher, Dan A. Ostlind, Franz A. Preiser, Bruce O. Linn, James M. Schaeffer, Alexander R Matzuk, P. Eskola
Publikováno v:
Journal of Medicinal Chemistry. 32:375-381
The reactions of sulfonate esters of the allylic/homoallylic 13-alcohol of 5-O-(tert-butyldimethylsilyl)-22,23-dihydroavermectin B1a aglycon (1a) were investigated. Nucleophilic substitution gave 13 beta-chloro and 13 beta-iodo derivatives, while sol
Autor:
Alexander R Matzuk, Helmut Mrozik, M. H. Fisher, Mary F. Woods, John C. Chabala, F. S. Waksmunski, P. Eskola
Publikováno v:
Tetrahedron Letters. 24:5333-5336
The structure of the avermectins and the milbemycins were interrelated by the conversion of 22,23-dihydroavermectin B1a and B1b aglycones (4) into 13-deoxy-22,23-dihydroavermectin B1a aglycone (9) and 13-deoxy-22,23-dihydroavermectin B1b aglycone (11
Publikováno v:
Journal of the American Chemical Society. 77:697-700
Autor:
Horace D Brown, Nelson R. Trenner, Robert E. Harman, Alexander R Matzuk, Dominick J. Tocco, Rudolf P. Buhs, Holly E. Mertel
Publikováno v:
Journal of Medicinal Chemistry. 7:399-405
Autor:
Dan A. Ostlind, Aino Lusi, A. Grodski, R. F. Riek, P. Eskola, Wu Mt, G. Schwartzkopf, Peter Kulsa, L. E. Olen, Richard J. Bochis, Helmut Mrozik, William C. Campbell, R. E. Harmon, J. D. Milkowski, Bruce O. Linn, Waksmunski S, Hoff Dale R, L. H. Peterson, Alexander R Matzuk, C. H. Shunk
Publikováno v:
Journal of Medicinal Chemistry. 20:1225-1227
The synthesis and fasciolicidal activity of 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide are reported. A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves
Publikováno v:
The Journal of Organic Chemistry. 26:5052-5054
Publikováno v:
The Journal of Organic Chemistry. 27:961-963