Zobrazeno 1 - 10
of 249
pro vyhledávání: '"A R, Judkins"'
Autor:
Simran Maggo, Liam Y. North, Aime Ozuna, Dejerianne Ostrow, Yander R. Grajeda, Hesamedin Hakimjavadi, Jennifer A. Cotter, Alexander R. Judkins, Pat Levitt, Xiaowu Gai
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
The mitochondrion is a multifunctional organelle that modulates multiple systems critical for homeostasis during pathophysiological stress. Variation in mitochondrial DNA (mtDNA) copy number (mtDNAcn), a key mitochondrial change associated with chron
Externí odkaz:
https://doaj.org/article/c4a5d9846d754dc9bc7df7a2c19feabc
Autor:
Lishuang Shen, Jennifer Dien Bard, Timothy J. Triche, Alexander R. Judkins, Jaclyn A. Biegel, Xiaowu Gai
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 885-893 (2021)
Mutations in the SARS-CoV-2 Membrane (M) gene are relatively uncommon. The M gene encodes the most abundant viral structural protein, and is implicated in multiple viral functions, including initial attachment to the host cell via heparin sulphate pr
Externí odkaz:
https://doaj.org/article/36225cc591ed41b89d2c56eb4a2cafd2
Autor:
Lishuang Shen, Jennifer Dien Bard, Timothy J. Triche, Alexander R. Judkins, Jaclyn A. Biegel, Xiaowu Gai
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 1293-1299 (2021)
The SARS-CoV-2 B.1.1.7 lineage is highly infectious and as of April 2021 accounted for 92% of COVID-19 cases in Europe and 59% of COVID-19 cases in the U.S. It is defined by the N501Y mutation in the receptor-binding domain (RBD) of the Spike (S) pro
Externí odkaz:
https://doaj.org/article/f8aa19448b194282a64ae08f50d5999a
Autor:
Drew Pratt, Martha Quezado, Zied Abdullaev, Debra Hawes, Fusheng Yang, Hugh J. L. Garton, Alexander R. Judkins, Rajen Mody, Arul Chinnaiyan, Kenneth Aldape, Carl Koschmann, Sriram Venneti
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-5 (2020)
Externí odkaz:
https://doaj.org/article/915b06c5e41b4f219e540b3eb6357b08
Autor:
Murad Alturkustani, Jennifer A. Cotter, Roshan Mahabir, Debra Hawes, Carl Koschmann, Sriram Venneti, Alexander R. Judkins, Linda J. Szymanski
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/a673982b1c4b44b2ae8489a02a9b9649
Autor:
Yibo Xue, Brian Meehan, Elizabeth Macdonald, Sriram Venneti, Xue Qing D. Wang, Leora Witkowski, Petar Jelinic, Tim Kong, Daniel Martinez, Geneviève Morin, Michelle Firlit, Atefeh Abedini, Radia M. Johnson, Regina Cencic, Jay Patibandla, Hongbo Chen, Andreas I. Papadakis, Aurelie Auguste, Iris de Rink, Ron M. Kerkhoven, Nicholas Bertos, Walter H. Gotlieb, Blaise A. Clarke, Alexandra Leary, Michael Witcher, Marie-Christine Guiot, Jerry Pelletier, Josée Dostie, Morag Park, Alexander R. Judkins, Ralf Hass, Douglas A. Levine, Janusz Rak, Barbara Vanderhyden, William D. Foulkes, Sidong Huang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is driven by SMARCA4 loss. Here the authors demonstrate that SCCOHT cells are highly sensitive to CDK4/6 inhibition and provide mechanistic insights, whereby this druggable vulnerability
Externí odkaz:
https://doaj.org/article/a9bfc57c02f44dfc91dacd68ff8a6a66
Autor:
Yibo Xue, Brian Meehan, Zheng Fu, Xue Qing D. Wang, Pierre Olivier Fiset, Ralf Rieker, Cameron Levins, Tim Kong, Xianbing Zhu, Geneviève Morin, Lashanda Skerritt, Esther Herpel, Sriram Venneti, Daniel Martinez, Alexander R. Judkins, Sungmi Jung, Sophie Camilleri-Broet, Anne V. Gonzalez, Marie-Christine Guiot, William W. Lockwood, Jonathan D. Spicer, Abbas Agaimy, William A. Pastor, Josée Dostie, Janusz Rak, William D. Foulkes, Sidong Huang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Non-small cell lung cancers with inactivating SMARCA4 mutations are currently undruggable. Here, the authors show that the absence of SMARCA4/2 reduces chromatin accessibility at the CCND1 locus, leading to a subsequent reduction in cyclin D1 express
Externí odkaz:
https://doaj.org/article/f919a450f672493c812a00c6c5045ab6
Autor:
Thao T. Truong, Alex Ryutov, Utsav Pandey, Rebecca Yee, Lior Goldberg, Deepa Bhojwani, Paibel Aguayo-Hiraldo, Benjamin A. Pinsky, Andrew Pekosz, Lishuang Shen, Scott D. Boyd, Oliver F. Wirz, Katharina Röltgen, Moiz Bootwalla, Dennis T. Maglinte, Dejerianne Ostrow, David Ruble, Jennifer H. Han, Jaclyn A. Biegel, Maggie Li, ChunHong Huang, Malaya K. Sahoo, Pia S. Pannaraj, Maurice O'Gorman, Alexander R. Judkins, Xiaowu Gai, Jennifer Dien Bard
Publikováno v:
EBioMedicine, Vol 67, Iss , Pp 103355- (2021)
Background: There is increasing concern that persistent infection of SARS-CoV-2 within immunocompromised hosts could serve as a reservoir for mutation accumulation and subsequent emergence of novel strains with the potential to evade immune responses
Externí odkaz:
https://doaj.org/article/42209873b5b849b2806a3d10b8822b27
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Genomic analysis of SARS-CoV-2 sequences is crucial in determining the effectiveness of prudent safer at home measures in the United States (US). By haplotype analysis of 6,356 US isolates, we identified a pattern of strongly localized outbreaks at t
Externí odkaz:
https://doaj.org/article/8bc3c67240da4c278b62c7403755aa51
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
SMARCB1 mutations predispose to rhabdoid tumors and schwannomas but the mechanisms underlying the tumor type specificity are unknown. Here the authors present new mouse models and show that early Smarcb1 loss causes rhabdoid tumors whereas loss at la
Externí odkaz:
https://doaj.org/article/1faf2971b5a4423bb8a856e7f90310eb