Zobrazeno 1 - 10
of 759
pro vyhledávání: '"A R, Isles"'
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionImprinted genes are expressed from one parental allele as a consequence of epigenetic processes initiated in the germline. Consequently, their ability to influence phenotype depends on their parent-of-origin. Recent research suggests that
Externí odkaz:
https://doaj.org/article/bd56a482532e491f80afd8b6b5191d78
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0298717 (2024)
Loss of function (LoF) mutations affecting the histone methyl transferase SETD1A are implicated in the aetiology of a range of neurodevelopmental disorders including schizophrenia. We examined indices of development and adult behaviour in a mouse mod
Externí odkaz:
https://doaj.org/article/eb3b3a06bced421e9ae528b61631e47c
Autor:
Matthew J Higgs, Anna E Webberley, Alasdair J Allan, Moaz Talat, Rosalind M John, Anthony R Isles
Publikováno v:
PLoS Genetics, Vol 19, Iss 10, p e1010961 (2023)
Imprinted genes are subject to germline epigenetic modification resulting in parental-specific allelic silencing. Although genomic imprinting is thought to be important for maternal behaviour, this idea is based on serendipitous findings from a small
Externí odkaz:
https://doaj.org/article/1f2126a47df8452f857b46edee61ac03
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-22 (2022)
Abstract Background Although a number of imprinted genes are known to be highly expressed in the brain, and in certain brain regions in particular, whether they are truly over-represented in the brain has never been formally tested. Using thirteen si
Externí odkaz:
https://doaj.org/article/2a1913bace3c4c9eaee4600aec7dd409
Autor:
Mouhamed Alsaqati, Brittany A. Davis, Jamie Wood, Megan M. Jones, Lora Jones, Aishah Westwood, Olena Petter, Anthony R. Isles, David Linden, Marianne Van den Bree, Michael Owen, Jeremy Hall, Adrian J. Harwood
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Genetic evidence indicates disrupted epigenetic regulation as a major risk factor for psychiatric disorders, but the molecular mechanisms that drive this association remain to be determined. EHMT1 is an epigenetic repressor that is causal fo
Externí odkaz:
https://doaj.org/article/a29feaa54d654c329a44032677eee659
Autor:
Anthony R. Isles
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Imprinted genes are a subset of mammalian genes that are subject to germline parent-specific epigenetic modifications leading monoallelic expression. Imprinted gene expression is particularly prevalent in the brain and it is unsurprising tha
Externí odkaz:
https://doaj.org/article/704c36c4dd514c6b833906b8f4597f89
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Prader-Willi Syndrome (PWS) is a neurodevelopmental disorder caused by mutations affecting paternal chromosome 15q11-q13, and characterized by hypotonia, hyperphagia, impaired cognition, and behavioural problems. Psychotic illness is a chall
Externí odkaz:
https://doaj.org/article/bfe9406a565643728a0bb57272fc6102
Autor:
David J. Harrison, Hugo D. J. Creeth, Hannah R. Tyson, Raquel Boque-Sastre, Anthony R. Isles, Rupert Palme, Chadi Touma, Rosalind M. John
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Preclinical mental health research relies upon animal models, and whilst many encouraging advances are being made, reproducibility and translational relevance may be limited by sub-optimal testing or model choices. Animal behaviors are complex and te
Externí odkaz:
https://doaj.org/article/b5471d2be495409ca0f9ab1701e39768
Autor:
Anna B. Janssen, Katrina A. Savory, Samantha M. Garay, Lorna Sumption, William Watkins, Isabel Garcia-Martin, Nicola A. Savory, Anouk Ridgway, Anthony R. Isles, Richard Penketh, Ian R. Jones, Rosalind M. John
Publikováno v:
BJPsych Open, Vol 4, Pp 354-360 (2018)
BackgroundIn the UK, 11.8% of expectant mothers undergo an elective caesarean section (ELCS) representing 92 000 births per annum. It is not known to what extent this procedure has an impact on mental well-being in the longer term.AimsTo determine th
Externí odkaz:
https://doaj.org/article/afe36821dfa243f4bb6f2e32d09eab1c
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Preterm birth complications are the leading cause of child death worldwide and a top global health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral palsy and impairment of movement, cognition, and behavior
Externí odkaz:
https://doaj.org/article/a15ee570cbcd4f1ca5a0d794394f5c68