Zobrazeno 1 - 10
of 522
pro vyhledávání: '"A R, Humphrey"'
Autor:
Jian-Fang Ning, Monica Stanciu, Melissa R. Humphrey, Joshua Gorham, Hiroko Wakimoto, Reiko Nishihara, Jacqueline Lees, Lee Zou, Robert L. Martuza, Hiroaki Wakimoto, Samuel D. Rabkin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
PARP inhibitors are mainly used to treat BRCA1/2 mutated cancers. Here, the authors show that MYC amplified glioblastomas are sensitive to PARP inhibition due to CDK18 repression, which impairs ATR regulated homologous recombination repair, and that
Externí odkaz:
https://doaj.org/article/403bcdc87a4246559e313ab4b0cb3355
Autor:
Lei Wang, Jianfang Ning, Hiroaki Wakimoto, Shulin Wu, Chin-lee Wu, Melissa R. Humphrey, Samuel D. Rabkin, Robert L. Martuza
Publikováno v:
Molecular Therapy: Oncolytics, Vol 13, Iss , Pp 58-66 (2019)
Novel therapies to override chemo-radiation resistance in prostate cancer (PCa) are needed. Prostate cancer sphere-forming cells (PCSCs) (also termed prostate cancer stem-like cells) likely participate in tumor progression and recurrence, and they ar
Externí odkaz:
https://doaj.org/article/18c5510430bf466ab259585393bc969e
Autor:
Matthew S. Winston, Marc Poirier, Zhijian Liu, Feng Peng, Guy R. Humphrey, John A. McIntosh, Mikhail Reibarkh, Fengqiang Wang, Erik D. Guetschow, Steve Castro, Erik Hoyt, David J. Lamberto, Kevin Sirk
Publikováno v:
Organic Process Research & Development. 27:179-188
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acc86545e85638ae22f318904489ad7f
https://doi.org/10.1021/acs.oprd.2c00327
https://doi.org/10.1021/acs.oprd.2c00327
Autor:
Omar Ali, Louella B. Amos, Bethany Auble, Donald Basel, Shannon H. Baumer-Mouradian, Ashley Beattie, Geetanjali Bora, Brett J. Bordini, Brian R. Branchford, Amanda M. Brandow, Ryan Byrne, Gisela G. Chelimsky, Thomas C. Chelimsky, Paula Cody, Gary Cohen, Deborah M. Costakos, Emily M. Densmore, John C. Densmore, Patricia A. Donohoue, Amy L. Drendel, Garrett Elsner, Raquel Farias-Moeller, Shayne D. Fehr, Susan Feigelman, Veronica H. Flood, Jessica Francis, Julia Fritz, Sandra Gage, Bhaskar Gurram, Matthew M. Harmelink, Kristen E. Holland, Stephen R. Humphrey, Anna R. Huppler, Susan L. Jarosz, S. Anne Joseph, Alvina R. Kansra, Virginia Keane, Robert M. Kliegman, Julie M. Kolinski, Chamindra G. Konersman, Kathleen A. Koth, Katja Kovacic, Amornluck Krasaelap, John V. Kryger, Sara M. Lauck, Tracey H. Liljestrom, Ahmad Marashly, Seema Menon, Adrian Miranda, Michelle L. Mitchell, Amy Moskop, Michael Muriello, James J. Nocton, Joshua Noe, Cynthia G. Pan, Andrew N. Pelech, Brittany Player, Jacquelyn M. Powers, Angela L. Rabbitt, Amanda Rogers, John M. Routes, Mark Simms, Rajasree Sreedharan, Alyssa Stephany, Julie Talano, Grzegorz W. Telega, Heather Toth, Scott K. Van Why, Sarah Vepraskas, James W. Verbsky, Bernadette Vitola, Kevin D. Walter, Michael Weisgerber, Peter M. Wolfgram, Sarah C. Yale, Alicia C. Zolkoske
Publikováno v:
Nelson Pediatric Symptom-Based Diagnosis: Common Diseases and their Mimics ISBN: 9780323761741
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7de430587cd708229f04dc59615cfe76
https://doi.org/10.1016/b978-0-323-76174-1.01002-6
https://doi.org/10.1016/b978-0-323-76174-1.01002-6
Autor:
Michelle M. Aleo, James Messamore, Betsy A. Nieto, Timothy J. Fleck, William R. Humphrey, Eileen M. Coscarelli, Sean P. Mahabir, Robert B. McCall, Andrea J. Gonzales
Publikováno v:
Veterinary immunology and immunopathology. 256
Canine atopic dermatitis (AD) is associated with increased levels of allergen-specific IgE due to hyper-sensitization to environmental allergens. Intradermal testing (IDT) and allergen-specific IgE serology testing are often used to determine the all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d18eb8508f37980d04e224abe0e6b87
https://pubmed.ncbi.nlm.nih.gov/36603446
https://pubmed.ncbi.nlm.nih.gov/36603446
Autor:
Birgit Kosjek, Rishi G. Vaswani, Neil A. Strotman, Jun Pan, Chaoxian Cai, Rebecca T. Ruck, Guy R. Humphrey
Publikováno v:
Organic Process Research & Development. 26:648-656
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82a2691bca6cc557c5dde52ad2cc5c66
https://doi.org/10.1021/acs.oprd.1c00128
https://doi.org/10.1021/acs.oprd.1c00128
Autor:
Wendy B. London, Ellen Haddock, Danny Mansour, Eman Bahrani, Lacey Kruse, Stephen R. Humphrey, Tova Rogers, Sally Robinson, Jennifer T. Huang, Kate Travis, Kristen P. Hook, Carrie C. Coughlin, Lily Chen, Pedram Gerami, Meera Brahmbhatt, Gary Tran, Zachary Wolner, Julie Nguyen, Diana Bartenstein, Elena B. Hawryluk, Ashfaq A. Marghoob, Lawrence F. Eichenfield, Elena Pope, Pei-Chi Kao, Birgitta Schmidt, Thuy L. Phung, Connie S. Zhong, Tom Raisanen, Leslie P. Lawley
Publikováno v:
Journal of the American Academy of Dermatology. 84:1472-1476
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d64a8dc8b8f9564f3601d8b45098fb1
https://doi.org/10.1016/j.jaad.2020.07.046
https://doi.org/10.1016/j.jaad.2020.07.046
Autor:
Anne E. Mohan, Siqing Song, Hsieh Yao D. Chang, Si-Wei Zhang, Patrick Larpent, Wenjun Liu, Michael DiBenedetto, Eric B. Sirota, Michael J. Di Maso, Richard Desmond, Kevin M. Maloney, Ivan H. Lee, Alfred Y. Lee, Guy R. Humphrey, Embarek Alwedi, Hong Ren
Publikováno v:
Organic Process Research & Development. 24:2498-2504
The development of a sustainable commercial salt formation process for gefapixant citrate (MK-7264), an investigational new P2X3 antagonist for the treatment of chronic cough, is described. Due to ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::facd961a62dfed3fd28d482411a9320b
https://doi.org/10.1021/acs.oprd.0c00260
https://doi.org/10.1021/acs.oprd.0c00260
Autor:
Eric B. Sirota, Karthik Narsimhan, Feng Peng, Mark Weisel, Alfred Y. Lee, Rebecca A. Arvary, Claire Lee, Daniel Bishara, Kevin M. Maloney, Andrew Brunskill, François Lévesque, Patrick Larpent, Michael Whittington, John R. Naber, Guy R. Humphrey, Dan Lehnherr, Si-Wei Zhang
Publikováno v:
Organic Process Research & Development. 24:2453-2461
Various synthetic routes to 2-isopropyl-4-methoxyphenol 3, the phenol core of Gefapixant citrate (MK-7264), are described, which provide better alternatives to the initial four-step supply route. T...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d1151aa0b8950e409e75134288d2f80
https://doi.org/10.1021/acs.oprd.0c00241
https://doi.org/10.1021/acs.oprd.0c00241
Autor:
Michael J. Di Maso, Embarek Alwedi, Guy R. Humphrey, Richard Desmond, Louis-Charles Campeau, Lisa Jellett, John R. Naber, Hong Ren, Hsieh Yao D. Chang, Douglas A. L. Otte, Hong Gao, Michael A. Zompa, Si-Wei Zhang, Gary E. Martin, Alfred Y. Lee, Wenjun Liu, Francisco J. Guzman, Kevin M. Maloney, Feng Peng, Elizabeth Fisher, Rebecca T. Ruck, Dan Lehnherr, Anne E. Mohan, Glenn Spencer, Siqing Song, Kallol Basu, Rebecca A. Arvary, Sachin Lohani
Publikováno v:
Organic Process Research & Development. 24:2445-2452
A robust, green, and sustainable manufacturing process has been developed for the synthesis of gefapixant citrate, a P2X3 receptor antagonist that is under investigation for the treatment of refrac...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95c8b1da5db499a674207974d58e42c1
https://doi.org/10.1021/acs.oprd.0c00248
https://doi.org/10.1021/acs.oprd.0c00248