Výsledky vyhledávání - "A R, Frackelton"

Src family tyrosine kinases participate in insulin-like growth factor I mitogenic signaling in 3T3-L1 cells

Autor: C M, Boney, H, Sekimoto, P A, Gruppuso, A R, Frackelton

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 12(7)

Insulin-like growth factor-I (IGF-I) stimulates proliferation and differentiation of many cell types, including preadipocytes. We have previously shown that IGF-I stimulates proliferation of 3T3-L1 preadipocytes through activation of the extracellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12da69c935c2ab3504526b0521e0dd6a
https://pubmed.ncbi.nlm.nih.gov/11457735

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Combining suramin and a chimeric toxin directed to basic fibroblast growth factor receptors increases therapeutic efficacy against human melanoma in an animal model

Autor: P A, Davol, S, Garza, A R, Frackelton

Publikováno v: Cancer. 86(9)

Suramin, which binds to and blocks autocrine and paracrine growth factors required for the proliferation of neoplastic cells, is a clinically effective antitumor agent against some human tumors; however, efficacy often is limited by toxicity. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c7d75ff7841cc27e4bfb977caba19f60
https://pubmed.ncbi.nlm.nih.gov/10547546

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Wortmannin, a phosphoinositide 3-kinase inhibitor, selectively enhances cytotoxicity of receptor-directed-toxin chimeras in vitro and in vivo

Autor: P A, Davol, A, Bizuneh, A R, Frackelton

Publikováno v: Anticancer research. 19(3A)

Generalized resistance of some neoplastic cell lines to treatment with ligand-toxin chimeras has been attributed to an increased rate of lysosomal uptake and degradation following endocytosis of the chimera-receptor complex. Because phosphoinositide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aee550b66f0dc18774a7f0e63522d728
https://pubmed.ncbi.nlm.nih.gov/10470104

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Targeting human prostatic carcinoma through basic fibroblast growth factor receptors in an animal model: characterizing and circumventing mechanisms of tumor resistance

Autor: P A, Davol, A R, Frackelton

Publikováno v: The Prostate. 40(3)

Basic fibroblast growth factor receptors on DU145 human prostatic carcinoma xenografts serve as targets for the delivery of a growth factor-toxin chimera, basic fibroblast growth factor-saporin (bFGF-SAP), which produces significant antitumor activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b0a01d19645e0408b4de13257b470f46
https://pubmed.ncbi.nlm.nih.gov/10398280

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Shc dominant negative disrupts cell cycle progression in both G0-G1 and G2-M of ErbB2-positive breast cancer cells

Autor: L E, Stevenson, K S, Ravichandran, A R, Frackelton

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 10(1)

The Shc protein helps to transmit signals from receptor and cytoplasmic tyrosine kinases to Ras. We have shown that several breast cancer cell lines (MDA-MB-453, BT474, MDA-MB-361, and SKBR3), which overexpress the ErbB2 receptor tyrosine kinase, con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::70e1fb36916008d2be1b5ae900fd10a8
https://pubmed.ncbi.nlm.nih.gov/9950219

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The mitotoxin, basic fibroblast growth factor-saporin, effectively targets human prostatic carcinoma in an animal model

Autor: P, Davol, A R, Frackelton

Publikováno v: The Journal of urology. 156(3)

The antitumor activity of the mitotoxin basic fibroblast growth factor-saporin (bFGF-SAP) against human prostatic carcinoma DU 145 was examined in athymic nude mice. Therapeutic efficacy was evaluated on the basis of dose, route of administration and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e18f491b09b3e875826ebb024a693600
https://pubmed.ncbi.nlm.nih.gov/8709341

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Modulation of p53 expression by human recombinant interferon-alpha2a correlates with abrogation of cisplatin resistance in a human melanoma cell line

Autor: P A, Davol, F A, Goulette, A R, Frackelton, J W, Darnowski

Publikováno v: Cancer research. 56(11)

G3361/CP cells, a cisplatin (CDDP)-resistant subclone of the human melanoma cell line G3361, overexpress wild-type p53 protein and demonstrate an increase in the percentage of cells in G0--G1 arrest compared to parental cells. Exposing G3361/CP cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6cabe39cc180a118f7d2d1dfcb4f02d0
https://pubmed.ncbi.nlm.nih.gov/8653690

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Effects of tyrosine kinase inhibitors on the proliferation of human breast cancer cell lines and proteins important in the ras signaling pathway

Autor: J W, Clark, A, Santos-Moore, L E, Stevenson, A R, Frackelton

Publikováno v: International journal of cancer. 65(2)

Breast cancers frequently over-express a number of growth factor receptors. In addition, elevated src family kinase activity is present in a percentage of these neoplasms and has been implicated in signal transduction in these cells. Therefore, inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d320847562fc4517532b414423523146
https://pubmed.ncbi.nlm.nih.gov/8567115

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