Zobrazeno 1 - 10
of 377
pro vyhledávání: '"A R, Denison"'
Autor:
Nian E. Zhou, Su Tang, Xuelin Bian, Maloy K. Parai, Inna V. Krieger, Armando Flores, Pradeep K. Jaiswal, Radha Bam, Jeremy L. Wood, Zhe Shi, Laura J. Stevens, Trevor Scobey, Meghan V. Diefenbacher, Fernando R. Moreira, Thomas J. Baric, Arjun Acharya, Joonyoung Shin, Manish M. Rathi, Karen C. Wolff, Laura Riva, Malina A. Bakowski, Case W. McNamara, Nicholas J. Catanzaro, Rachel L. Graham, David C. Schultz, Sara Cherry, Yoshihiro Kawaoka, Peter J. Halfmann, Ralph S. Baric, Mark R. Denison, Timothy P. Sheahan, James C. Sacchettini
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114929- (2024)
Summary: Safe, effective, and low-cost oral antiviral therapies are needed to treat those at high risk for developing severe COVID-19. To that end, we performed a high-throughput screen to identify non-peptidic, non-covalent inhibitors of the SARS-Co
Externí odkaz:
https://doaj.org/article/fee5e4e3bedd475abadbb75db127898b
Autor:
Samantha L. Grimes, Mark R. Denison
Publikováno v:
Virus Research, Vol 346, Iss , Pp 199401- (2024)
The coronavirus nonstructural protein (nsp) 13 encodes an RNA helicase (nsp13-HEL) with multiple enzymatic functions, including unwinding and nucleoside phosphatase (NTPase) activities. Attempts for enzymatic inactivation have defined the nsp13-HEL a
Externí odkaz:
https://doaj.org/article/4dae30233ae4451099c1b975a1cccc68
Publikováno v:
mSystems, Vol 9, Iss 7 (2024)
ABSTRACT Winter is a relatively under-studied season in freshwater ecology. The paucity of wintertime surveys has led to a lack of knowledge regarding microbial community activity during the winter in Lake Erie, a North American Great Lake. Viruses s
Externí odkaz:
https://doaj.org/article/44cc9e2d08654f11a6ce2811bf4eddbb
Autor:
Maximilian H. Carter, Jennifer Gribble, Julia R. Diller, Mark R. Denison, Sara A. Mirza, James D. Chappell, Natasha B. Halasa, Kristen M. Ogden
Publikováno v:
Viruses, Vol 16, Iss 6, p 978 (2024)
Human rotaviruses exhibit limited tropism and replicate poorly in most cell lines. Attachment protein VP4 is a key rotavirus tropism determinant. Previous studies in which human rotaviruses were adapted to cultured cells identified mutations in VP4.
Externí odkaz:
https://doaj.org/article/be898c080a3541a38760c10025dd7ee2
Autor:
Samantha L. Grimes, Young J. Choi, Anoosha Banerjee, Gabriel Small, Jordan Anderson-Daniels, Jennifer Gribble, Andrea J. Pruijssers, Maria L. Agostini, Alexandra Abu-Shmais, Xiaotao Lu, Seth A. Darst, Elizabeth Campbell, Mark R. Denison
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Coronaviruses (CoVs) encode nonstructural proteins 1–16 (nsps 1–16) which form replicase complexes that mediate viral RNA synthesis. Remdesivir (RDV) is an adenosine nucleoside analog antiviral that inhibits CoV RNA synthesis. RDV resist
Externí odkaz:
https://doaj.org/article/351eda1dc8534b2e94fffb7f9053450a
Autor:
William D. Hunt, Nael A. McCarty, Eduardo Martinez Marin, Ryan S. Westafer, Phillip R. Yamin, Guiying Cui, Andrew W. Eckford, Douglas R. Denison
Publikováno v:
Biophysical Reports, Vol 3, Iss 2, Pp 100108- (2023)
In this paper we present a transistor circuit model for cystic fibrosis transmembrane conductance regulator (CFTR) that seeks to map the functional form of CFTR both in wild type and mutants. The circuit architecture is configured so that the functio
Externí odkaz:
https://doaj.org/article/c472d962839449f199e0a70eef5cd4ad
Autor:
Wesley H. Self, Thomas G. Stewart, Allison P. Wheeler, Wissam El Atrouni, Amanda J. Bistran-Hall, Jonathan D. Casey, Vince D. Cataldo, James D. Chappell, Claudia S. Cohn, Jessica B. Collins, Mark R. Denison, Marjolein de Wit, Sheri L. Dixon, Abhijit Duggal, Terri L. Edwards, Magali J. Fontaine, Adit A. Ginde, Michelle S. Harkins, Thelma Harrington, Estelle S. Harris, Daanish Hoda, Tina S. Ipe, Stuti J. Jaiswal, Nicholas J. Johnson, Alan E. Jones, Maryrose Laguio-Vila, Christopher J. Lindsell, Jason Mallada, Manoj J. Mammen, Ryan A. Metcalf, Elizabeth A. Middleton, Simon Mucha, Hollis R. O’Neal, Sonal R. Pannu, Jill M. Pulley, Xian Qiao, Jay S. Raval, Jillian P. Rhoads, Harry Schrager, Carl Shanholtz, Nathan I. Shapiro, Stephen J. Schrantz, Isaac Thomsen, Krista K. Vermillion, Gordon R. Bernard, Todd W. Rice, For the Passive Immunity Trial for Our Nation (PassITON) Investigators
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background Convalescent plasma is being used widely as a treatment for coronavirus disease 2019 (COVID-19). However, the clinical efficacy of COVID-19 convalescent plasma is unclear. Methods The Passive Immunity Trial for Our Nation (PassITO
Externí odkaz:
https://doaj.org/article/09f00f69e5d142a1b19dcc01b4acebd6
Autor:
Timothy P. Sheahan, Amy C. Sims, Sarah R. Leist, Alexandra Schäfer, John Won, Ariane J. Brown, Stephanie A. Montgomery, Alison Hogg, Darius Babusis, Michael O. Clarke, Jamie E. Spahn, Laura Bauer, Scott Sellers, Danielle Porter, Joy Y. Feng, Tomas Cihlar, Robert Jordan, Mark R. Denison, Ralph S. Baric
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Remdesivir (RDV) is a broad-spectrum antiviral drug with activity against MERS coronavirus, but in vivo efficacy has not been evaluated. Here, the authors show that RDV has superior anti-MERS activity in vitro and in vivo compared to combination ther
Externí odkaz:
https://doaj.org/article/f17353d0fecb47bb853401bd79786ace
Autor:
Pavlo Gilchuk, Isaac Thomsen, Sandra Yoder, Eric Brady, James D. Chappell, Laura J. Stevens, Mark R. Denison, Rachel E. Sutton, Rita E. Chen, Laura A. VanBlargan, Naveenchandra Suryadevara, Seth J. Zost, Jonathan Schmitz, Jill M. Pulley, Michael S. Diamond, Jillian P. Rhoads, Gordon R. Bernard, Wesley H. Self, Todd W. Rice, Allison P. Wheeler, James E. Crowe, Jr., Robert H. Carnahan
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103602- (2022)
Summary: The COVID-19 pandemic revealed an urgent need for rapid profiling of neutralizing antibody responses and development of antibody therapeutics. The current Food and Drug Administration-approved serological tests do not measure antibody-mediat
Externí odkaz:
https://doaj.org/article/50ddb15ad4ec4f03a1aedb2f937e5006
Autor:
Ching-Lin Hsieh, Anne P. Werner, Sarah R. Leist, Laura J. Stevens, Ester Falconer, Jory A. Goldsmith, Chia-Wei Chou, Olubukola M. Abiona, Ande West, Kathryn Westendorf, Krithika Muthuraman, Ethan J. Fritch, Kenneth H. Dinnon, III, Alexandra Schäfer, Mark R. Denison, James D. Chappell, Ralph S. Baric, Barney S. Graham, Kizzmekia S. Corbett, Jason S. McLellan
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109929- (2021)
Summary: Current coronavirus (CoV) vaccines primarily target immunodominant epitopes in the S1 subunit, which are poorly conserved and susceptible to escape mutations, thus threatening vaccine efficacy. Here, we use structure-guided protein engineeri
Externí odkaz:
https://doaj.org/article/af2791637eea401ba71a9731ca3cb5c0