Zobrazeno 1 - 10
of 47
pro vyhledávání: '"A R, Carpinelli"'
Autor:
Zihao Deng, Marina R. Carpinelli, Tariq Butt, Graham W. Magor, Peinan Zhao, Kevin R. Gillinder, Andrew C. Perkins, Stephen M. Jane
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e37259- (2024)
Neural tube closure in vertebrates is achieved through a highly dynamic and coordinated series of morphogenic events involving neuroepithelium, surface ectoderm, and neural plate border. Failure of this process in the caudal region causes spina bifid
Externí odkaz:
https://doaj.org/article/631a6d4ff0564bf78c5f7172dabd262e
Autor:
Marina R. Carpinelli, Michael E. de Vries, Alana Auden, Tariq Butt, Zihao Deng, Darren D. Partridge, Lee B. Miles, Smitha R. Georgy, Jody J. Haigh, Charbel Darido, Simone Brabletz, Thomas Brabletz, Marc P. Stemmler, Sebastian Dworkin, Stephen M. Jane
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 3 (2020)
Cleft lip and palate are common birth defects resulting from failure of the facial processes to fuse during development. The mammalian grainyhead-like (Grhl1-3) genes play key roles in a number of tissue fusion processes including neurulation, epider
Externí odkaz:
https://doaj.org/article/6c38fe6274f442e8a75624c3c65d4743
Autor:
Jacqueline M. Ogier, Benedicta D. Arhatari, Marina R. Carpinelli, Bradley K. McColl, Michael A. Wilson, Rachel A. Burt
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Alternate splicing is a critical regulator of gene expression in eukaryotes, however genetic mutations can cause erroneous splicing and disease. Most recorded splicing disorders are caused by mutations of splice donor/acceptor sites, however
Externí odkaz:
https://doaj.org/article/dccb49ac7e9d41fc8ef1bf8b1792125f
Autor:
Eloisa A. Vilas-Boas, Christopher Carlein, Lisa Nalbach, Davidson C. Almeida, Emmanuel Ampofo, Angelo R. Carpinelli, Leticia P. Roma, Fernanda Ortis
Publikováno v:
Antioxidants, Vol 10, Iss 8, p 1305 (2021)
In type 1 diabetes (T1D) development, proinflammatory cytokines (PIC) released by immune cells lead to increased reactive oxygen species (ROS) production in β-cells. Nonetheless, the temporality of the events triggered and the role of different ROS
Externí odkaz:
https://doaj.org/article/b169413cbb0347bd9d392b45638c86d9
Autor:
Zihao Deng, Marina R. Carpinelli, Tariq Butt, Graham W. Magor, Andrew C. Perkins, Stephen M. Jane
Publikováno v:
Biochemical and biophysical research communications. 635
Neural tube closure is a dynamic morphogenic event in early embryonic development. Perturbations of this process through either environmental or genetic factors induce the severe congenital malformations known collectively as neural tube defects (NTD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de0d1d915e624285f9aa396f6e9244a
https://pubmed.ncbi.nlm.nih.gov/36283337
https://pubmed.ncbi.nlm.nih.gov/36283337
Autor:
Marina R. Carpinelli, Anne K. Voss, Michael G. Manning, Ashwyn A. Perera, Anne A. Cooray, Benjamin T. Kile, Rachel A. Burt
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 6, Pp 649-657 (2014)
Canavan disease is a leukodystrophy caused by mutations in the ASPA gene. This gene encodes the enzyme that converts N-acetylaspartate into acetate and aspartic acid. In Canavan disease, spongiform encephalopathy of the brain causes progressive menta
Externí odkaz:
https://doaj.org/article/1ddc3b90ceba4f57b3a172e26afbc0fa
Autor:
Maíra M.R. Valle, Eloisa Aparecida Vilas‐Boas, Camila F. Lucena, Simone A. Teixeira, Marcelo N. Muscara, Angelo R. Carpinelli
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Metformin is the first-line drug to treat type 2 diabetes mellitus. Its mechanism of action is still debatable, and recent studies report that metformin attenuates oxidative stress. This study evaluated the in vitro antioxidant effects of a broad ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdf82cde104f4722689dd326c671ce3
https://doi.org/10.1002/jbt.23007
https://doi.org/10.1002/jbt.23007
Autor:
Marina R. Carpinelli, Alana Auden, Charbel Darido, Dijina Swaroop, Jody J. Haigh, Katharina Haigh, Stephen M. Jane, Thao Nguyen, Zihao Deng, Tariq M. Butt, Darren D. Partridge, Benedicta D. Arhatari
The gene encoding the transcription factor, Grainyhead-like 3 (Grhl3), plays critical roles in mammalian development and homeostasis, and these have been uncovered through analysis of loss-of-function models. Grhl3-null embryos exhibit a range of gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::620961401e25f2305af1f55a1466f5b1
https://doi.org/10.21203/rs.3.rs-885196/v1
https://doi.org/10.21203/rs.3.rs-885196/v1
Autor:
Jacqueline M Ogier, Marina R Carpinelli, Benedicta D Arhatari, R C Andrew Symons, Benjamin T Kile, Rachel A Burt
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97559 (2014)
CHARGE syndrome is a rare human disorder caused by mutations in the gene encoding chromodomain helicase DNA binding protein 7 (CHD7). Characteristics of CHARGE are varied and include developmental ear and hearing anomalies. Here we report a novel mou
Externí odkaz:
https://doaj.org/article/691b24bcc35f4517b1e9cb1c0a99c15f
Autor:
Peter J. Anderson, Michael E. de Vries, Sebastian Dworkin, Stephen M. Jane, Alana Auden, Ariena Kersbergen, Darren D. Partridge, Kate D. Sutherland, Harley G Owens, Marina R. Carpinelli
Publikováno v:
Developmental dynamics : an official publication of the American Association of AnatomistsREFERENCES. 250(8)
Background The highly conserved Grainyhead-like (Grhl) family of transcription factors play critical roles in the development of the neural tube and craniofacial skeleton. In particular, deletion of family member Grainyhead-like 2 (Grhl2) leads to mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6732a9284f737dbf134812f035f00e
https://pubmed.ncbi.nlm.nih.gov/33638290
https://pubmed.ncbi.nlm.nih.gov/33638290