Zobrazeno 1 - 10
of 137
pro vyhledávání: '"A R, Bourgonje"'
Autor:
Sem Geertsema, Paul Geertsema, Lyanne M. Kieneker, Amaal E. Abdulle, Sacha la Bastide-van Gemert, Stephan J.L. Bakker, Robin P.F. Dullaart, Gerard Dijkstra, Ron T. Gansevoort, Klaas Nico Faber, Harry van Goor, Arno R. Bourgonje
Publikováno v:
Redox Biology, Vol 77, Iss , Pp 103408- (2024)
Background: Chronic Kidney Disease (CKD), is often detected late due to its asymptomatic nature in the early stage of the disease. Overproduction of reactive oxygen species contributes to various pathological processes through oxidative stress (OS),
Externí odkaz:
https://doaj.org/article/52210a27e2d548f083e62c515b0ee5bd
Publikováno v:
Microbiome, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract Background Elevated systemic antibody responses against gut microbiota flagellins are observed in both Crohn’s disease (CD) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), suggesting potential serological biomarkers for di
Externí odkaz:
https://doaj.org/article/a251cf6bffcf4ca0930a2f96d6925ffa
Autor:
Larissa E. Vlaming-van Eijk, Marian L.C. Bulthuis, Bernardina T.F. van der Gun, Karin I. Wold, Alida C.M. Veloo, María F. Vincenti González, Martin H. de Borst, Wilfred F.A. den Dunnen, Jan-Luuk Hillebrands, Harry van Goor, Adriana Tami, Arno R. Bourgonje
Publikováno v:
Redox Biology, Vol 76, Iss , Pp 103310- (2024)
Background: Post-COVID-19 syndrome (PCS) remains a major health issue worldwide, while its pathophysiology is still poorly understood. Systemic oxidative stress (OS) may be involved in PCS, which is reflected by lower circulating free thiols (R–SH,
Externí odkaz:
https://doaj.org/article/a30e2c9b85d84a4d80c759da9000dd59
Autor:
Shixian Hu, Arno R. Bourgonje, Ranko Gacesa, Bernadien H. Jansen, Johannes R. Björk, Amber Bangma, Iwan J. Hidding, Hendrik M. van Dullemen, Marijn C. Visschedijk, Klaas Nico Faber, Gerard Dijkstra, Hermie J. M. Harmsen, Eleonora A. M. Festen, Arnau Vich Vila, Lieke M. Spekhorst, Rinse K. Weersma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Disrupted host-microbe interactions at the mucosal level are key to the pathophysiology of IBD. This study aimed to comprehensively examine crosstalk between mucosal gene expression and microbiota in patients with IBD. To study tissue-specif
Externí odkaz:
https://doaj.org/article/7d585f4cd17d4027b8c1cce58bfea380
Autor:
Sergio Andreu-Sánchez, Aida Ripoll-Cladellas, Anna Culinscaia, Ozlem Bulut, Arno R. Bourgonje, Mihai G. Netea, Peter Lansdorp, Geraldine Aubert, Marc Jan Bonder, Lude Franke, Thomas Vogl, Monique G.P. van der Wijst, Marta Melé, Debbie Van Baarle, Jingyuan Fu, Alexandra Zhernakova
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109981- (2024)
Summary: Encounters with pathogens and other molecules can imprint long-lasting effects on our immune system, influencing future physiological outcomes. Given the wide range of microbes to which humans are exposed, their collective impact on health i
Externí odkaz:
https://doaj.org/article/a625eed26ff74ff68e49a04b0978d288
Autor:
Arno R. Bourgonje, Margery A. Connelly, Harry van Goor, Peter R. van Dijk, Robin P. F. Dullaart
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-11 (2023)
Abstract Background Triglyceride-rich lipoproteins (TRL) and low-density lipoproteins (LDL) are associated positively whereas high-density lipoproteins (HDL) are associated inversely with the development of new-onset type 2 diabetes (T2D). Here we st
Externí odkaz:
https://doaj.org/article/0cf75d689ff243c9a8eee1356ea2048f
Autor:
Shu Xu, Xiaozhi Li, Shenghong Zhang, Cancan Qi, Zhenhua Zhang, Ruiqi Ma, Liyuan Xiang, Lianmin Chen, Yijun Zhu, Ce Tang, Arno R. Bourgonje, Miaoxin Li, Yao He, Zhirong Zeng, Shixian Hu, Rui Feng, Minhu Chen
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Oxidative stress (OS) is a key pathophysiological mechanism in Crohn’s disease (CD). OS-related genes can be affected by environmental factors, intestinal inflammation, gut microbiota, and epigenetic changes. However, the role o
Externí odkaz:
https://doaj.org/article/c1c64b94b9dd4e7ab47adc1d63090663
Autor:
Arno R. Bourgonje, Martin F. Bourgonje, Sacha la Bastide‐van Gemert, Tom Nilsen, Clara Hidden, Ron T. Gansevoort, Stephan J. L. Bakker, Douwe J. Mulder, Robin P. F. Dullaart, Amaal E. Abdulle, Harry van Goor
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 1 (2024)
Background Low‐grade systemic inflammation is a relevant pathogenic mechanism underlying the development of hypertension. In this study, we hypothesized that plasma calprotectin levels, as a biomarker of neutrophil‐mediated inflammation, is assoc
Externí odkaz:
https://doaj.org/article/8f1c8b3047c142ccae464708a0274406
Autor:
Hussam Ghoti, Hala Zreid, Israa Ghoti, Arno R. Bourgonje, Arjan Diepstra, Harry van Goor, Irit Avivi, Hisham Jeadi, Larissa E. van Eijk, Günter Weiss
Publikováno v:
EClinicalMedicine, Vol 62, Iss , Pp 102096- (2023)
Summary: Background: COVID-19 has raised special concern for patients with β-thalassemia major (β-TM) due to frequent comorbidities, regular blood transfusions, and iron overload. However, the exact implications of COVID-19 for patients with β-TM
Externí odkaz:
https://doaj.org/article/55f8d4bd1f9b40e68e2be81d9883a3f7
Autor:
Arno R. Bourgonje, Sietse J. Wichers, Shixian Hu, Hendrik M. van Dullemen, Marijn C. Visschedijk, Klaas Nico Faber, Eleonora A. M. Festen, Gerard Dijkstra, Janneke N. Samsom, Rinse K. Weersma, Lieke M. Spekhorst
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Fatigue is a common and clinically challenging symptom in patients with inflammatory bowel diseases (IBD), occurring in ~ 50% of patients with quiescent disease. In this study, we aimed to investigate whether fatigue in patients with clinica
Externí odkaz:
https://doaj.org/article/1ca027029dca4c7482e2e2e9d0f9249d