Zobrazeno 1 - 10
of 2 122
pro vyhledávání: '"A Pridham"'
Autor:
Pridham, Glen, Tennankore, Karthik K., Rockwood, Kenneth, Worthen, George, Rutenberg, Andrew D.
We present a systems-level analysis of end-stage kidney disease (ESKD) with a dynamical network analysis of 14 commonly measured blood-based biomarkers in patients undergoing regular haemodialysis. Utilizing a validated pipeline for declining homeost
Externí odkaz:
http://arxiv.org/abs/2405.20523
Autor:
Pridham, Glen, Rutenberg, Andrew D.
Widespread interest in non-destructive biomarkers of aging has led to a curse of plenty: a multitude of biological ages that each proffers a 'true' health-adjusted age of an individual. While each measure provides salient information on the aging pro
Externí odkaz:
http://arxiv.org/abs/2309.10005
Autor:
Pridham, Glen, Rutenberg, Andrew D.
Publikováno v:
Sci Rep 13, 22140 (2023)
Using longitudinal study data, we dynamically model how aging affects homeostasis in both mice and humans. We operationalize homeostasis as a multivariate mean-reverting stochastic process. We hypothesize that biomarkers have stable equilibrium value
Externí odkaz:
http://arxiv.org/abs/2306.12448
Publikováno v:
Sci. Rep. 13 (2023) 1-10
We model the effects of disease and other exogenous damage during human aging. Even when the exogenous damage is repaired at the end of acute disease, propagated secondary damage remains. We consider both short-term mortality effects due to (acute) e
Externí odkaz:
http://arxiv.org/abs/2305.06808
Autor:
Kevin J. Pridham, Kasen R. Hutchings, Patrick Beck, Min Liu, Eileen Xu, Erin Saechin, Vincent Bui, Chinkal Patel, Jamie Solis, Leah Huang, Allison Tegge, Deborah F. Kelly, Zhi Sheng
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109921- (2024)
Summary: Resistance to chemotherapies such as temozolomide is a major hurdle to effectively treat therapy-resistant glioblastoma. This challenge arises from the activation of phosphatidylinositol 3-kinase (PI3K), which makes it an appealing therapeut
Externí odkaz:
https://doaj.org/article/5a04dfc5957141aab0cc95b2f89bf3bb
Autor:
Pridham, J. P.
We develop a characterisation of non-Archimedean derived analytic geometry based on dg enhancements of dagger algebras. This allows us to formulate derived analytic moduli functors for many types of pro-\'etale sheaves, and to construct shifted sympl
Externí odkaz:
http://arxiv.org/abs/2205.02292
Autor:
Erwin K. Gudenschwager Basso, Jing Ju, Eman Soliman, Caroline de Jager, Xiaoran Wei, Kevin J. Pridham, Michelle L. Olsen, Michelle H. Theus
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Monocytes represent key cellular elements that contribute to the neurological sequela following brain injury. The current study reveals that trauma induces the augmented release of a transcriptionally distinct CD115+/Ly6Chi monocyte populati
Externí odkaz:
https://doaj.org/article/4a71437ef1c1430cb5de1c3e6795ff40
Autor:
Jon Eugster, Jonathan Pridham
Publikováno v:
Rendiconti di Matematica e delle Sue Applicazioni, Vol 45, Iss 1-2, Pp 1-109 (2024)
Mostly aimed at an audience with backgrounds in geometry and homological algebra, these notes offer an introduction to derived geometry based on a lecture course given by the second author. The focus is on derived algebraic geometry, mainly in charac
Externí odkaz:
https://doaj.org/article/a8a9977467124a63bd3ff86404475f68
Publikováno v:
Advances in Theoretical and Mathematical Physics, Vol. 27, No. 5 (2023), pp. 1275-1332
We study the quantization of the canonical unshifted Poisson structure on the derived cotangent stack $T^\ast[X/G]$ of a quotient stack, where $X$ is a smooth affine scheme with an action of a (reductive) smooth affine group scheme $G$. This is achie
Externí odkaz:
http://arxiv.org/abs/2201.10225