Zobrazeno 1 - 10
of 933
pro vyhledávání: '"A Phillips JR"'
Autor:
Dun, Chen, Pan, Qiutai, Jin, Shikai, Stevens, Ria, Miller, Mitchell D., Phillips, Jr., George N., Kyrillidis, Anastasios
Determining the structure of a protein has been a decades-long open question. A protein's three-dimensional structure often poses nontrivial computation costs, when classical simulation algorithms are utilized. Advances in the transformer neural netw
Externí odkaz:
http://arxiv.org/abs/2310.03899
Autor:
Tom Pan, Chen Dun, Shikai Jin, Mitchell D. Miller, Anastasios Kyrillidis, George N. Phillips Jr.
Publikováno v:
Structural Dynamics, Vol 11, Iss 4, Pp 044701-044701-14 (2024)
Determining the atomic-level structure of a protein has been a decades-long challenge. However, recent advances in transformers and related neural network architectures have enabled researchers to significantly improve solutions to this problem. Thes
Externí odkaz:
https://doaj.org/article/35ebbaec82dd44a9a6ced8b4de52544e
Publikováno v:
IUCrJ, Vol 10, Iss 4, Pp 487-496 (2023)
The general de novo solution of the crystallographic phase problem is difficult and only possible under certain conditions. This paper develops an initial pathway to a deep learning neural network approach for the phase problem in protein crystallogr
Externí odkaz:
https://doaj.org/article/5f4e3dbe014048a3be76cba849b381eb
Publikováno v:
Structural Dynamics, Vol 11, Iss 1, Pp 014702-014702-12 (2024)
Adenylate kinase is a ubiquitous enzyme in living systems and undergoes dramatic conformational changes during its catalytic cycle. For these reasons, it is widely studied by genetic, biochemical, and biophysical methods, both experimental and theore
Externí odkaz:
https://doaj.org/article/452be095b90749f995e0cd79032f1118
Akademický článek
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Autor:
William M. Kettyle, Jean E. Klig, William R. Phillips, Jr., Joshua M. Kosowsky, Edward M. Hundert, Susan E. Farrell, Mary Ellen J. Goldhamer, John L. Dalrymple
Publikováno v:
MedEdPublish, Vol 13 (2023)
Background New approaches are needed to improve and destigmatize remediation in undergraduate medical education (UME). The COVID-19 pandemic magnified the need to support struggling learners to ensure competency and readiness for graduate medical edu
Externí odkaz:
https://doaj.org/article/3d7e9aed3c49484a91f0f60549d32d00
Autor:
Suraj Pandey, George Calvey, Andrea M. Katz, Tek Narsingh Malla, Faisal H. M. Koua, Jose M. Martin-Garcia, Ishwor Poudyal, Jay-How Yang, Mohammad Vakili, Oleksandr Yefanov, Kara A. Zielinski, Sasa Bajt, Salah Awel, Katarina Doerner, Matthias Frank, Luca Gelisio, Rebecca Jernigan, Henry Kirkwood, Marco Kloos, Jayanath Koliyadu, Valerio Mariani, Mitchell D. Miller, Grant Mills, Garrett Nelson, Jose L. Olmos Jr, Alireza Sadri, Tokushi Sato, Alexandra Tolstikova, Weijun Xu, Abbas Ourmazd, John C. H. Spence, Peter Schwander, Anton Barty, Henry N. Chapman, Petra Fromme, Adrian P. Mancuso, George N. Phillips Jr, Richard Bean, Lois Pollack, Marius Schmidt
Publikováno v:
IUCrJ, Vol 8, Iss 6, Pp 878-895 (2021)
Here, we illustrate what happens inside the catalytic cleft of an enzyme when substrate or ligand binds on single-millisecond timescales. The initial phase of the enzymatic cycle is observed with near-atomic resolution using the most advanced X-ray s
Externí odkaz:
https://doaj.org/article/fbdbd2a5c401447a974071c858ead28e
Autor:
Pan, Tom, Dun, Chen, Jin, Shikai, Miller, Mitchell D., Kyrillidis, Anastasios, Phillips Jr., George N.
Publikováno v:
Structural Dynamics; Jul2024, Vol. 11 Issue 4, p1-14, 14p
Publikováno v:
Accounting Horizons; Jun2024, Vol. 38 Issue 2, p27-43, 17p
Akademický článek
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