Zobrazeno 1 - 10
of 55
pro vyhledávání: '"A Pejmun Haghighi"'
Autor:
Suzana Ulian-Benitez, Abigail Strausbaugh Hjelmstad, Guilherme Oliveira Barbosa, Pejmun Haghighi
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101377- (2022)
Summary: In the fly brain, neurodegeneration is detected by the presence of vacuoles using conventional hematoxylin and eosin (H&E) or phalloidin staining, which are lengthy and expensive processes. Here, we present a faster and cost-effective 2-day
Externí odkaz:
https://doaj.org/article/5ea826a81b1c477ab6d69ccaff9900c5
Autor:
Mathias A. Böhme, Anthony W. McCarthy, Andreas T. Grasskamp, Christine B. Beuschel, Pragya Goel, Meida Jusyte, Desiree Laber, Sheng Huang, Ulises Rey, Astrid G. Petzoldt, Martin Lehmann, Fabian Göttfert, Pejmun Haghighi, Stefan W. Hell, David Owald, Dion Dickman, Stephan J. Sigrist, Alexander M. Walter
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Synaptic plasticity ensures functionality during perturbations and enables memory formation. Here, the authors describe homeostatic functional and nano-modular active zone modifications for immediate and long-lasting enhancement of neurotransmitter r
Externí odkaz:
https://doaj.org/article/9733b2fe50774e4e995b69653b092187
Autor:
Yumaine Chong, Natasha Saviuk, Brigitte Pie, Nathan Basisty, Ryan K. Quinn, Birgit Schilling, Nahum Sonenberg, Ellis Cooper, A. Pejmun Haghighi
Publikováno v:
Cell Reports, Vol 23, Iss 1, Pp 11-22 (2018)
Summary: Throughout the developing nervous system, considerable synaptic re-organization takes place as postsynaptic neurons extend dendrites and incoming axons refine their synapses, strengthening some and eliminating others. It is well accepted tha
Externí odkaz:
https://doaj.org/article/ed6128aeb732442880980fbe1448c6f8
Publikováno v:
Cell Reports, Vol 26, Iss 7, Pp 1774-1786.e4 (2019)
Summary: Pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) induce an age-dependent loss of dopaminergic (DA) neurons. We have identified Furin 1, a pro-protein convertase, as a translational target of LRRK2 in DA neurons. Transgenic knockd
Externí odkaz:
https://doaj.org/article/151996a4837f4ca9b1958407794bafa2
Autor:
Jay Penney, Kazuya Tsurudome, Edward H. Liao, Grant Kauwe, Lindsay Gray, Akiko Yanagiya, Mario R. Calderon, Nahum Sonenberg, A. Pejmun Haghighi
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Mutations in the protein LRRK2 have been associated with Parkinson's disease but little is still known about the basic functions of the protein in the brain. Here the authors show that in fruit flies, LRRK2 regulates retrograde homeostatic synaptic c
Externí odkaz:
https://doaj.org/article/28b871da68c441029f3092bf68c4f2c8
Autor:
Edward H Liao, Lindsay Gray, Kazuya Tsurudome, Wassim El-Mounzer, Fatima Elazzouzi, Christopher Baim, Sarah Farzin, Mario R Calderon, Grant Kauwe, A Pejmun Haghighi
Publikováno v:
PLoS Genetics, Vol 14, Iss 1, p e1007184 (2018)
Retrograde signaling is essential for neuronal growth, function and survival; however, we know little about how signaling endosomes might be directed from synaptic terminals onto retrograde axonal pathways. We have identified Khc-73, a plus-end direc
Externí odkaz:
https://doaj.org/article/f0d4154401204b53a4f4d9765720c9a9
Neuronal response to nutrient availability plays an important role in the maintenance of cellular homeostasis and behavioral response to the environment in higher eukaryotes. However, we know little about how neuronal function is influenced by acute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f5e20f19bd8d67bbcee04ed9c4ad702
https://doi.org/10.1101/2022.11.03.515133
https://doi.org/10.1101/2022.11.03.515133
Publikováno v:
bioRxiv
The coronavirus disease 2019 (COVID19) continues to spread despite global vaccination efforts (1). This, alongside the rapid emergence of vaccine resistant variants, creates a need for orthogonal therapeutic strategies targeting more conserved facets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e068985336e84962da8aa335b5894046
https://europepmc.org/articles/PMC9603819/
https://europepmc.org/articles/PMC9603819/
Autor:
Xiaoyu Tracy Cai, Stephen R. Quake, Yuxin Liang, Jovencio Borneo, Martin Borch Jensen, Pejmun Haghighi, Hongjie Li, Elie Maksoud, Liqun Luo, Heinrich Jasper
Publikováno v:
Nature
Infection-induced aversion against enteropathogens is a conserved sickness behaviour that can promote host survival1,2. The aetiology of this behaviour remains poorly understood, but studies in Drosophila have linked olfactory and gustatory perceptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db7de570b8db33d4093ff1fecd4f87c4
https://doi.org/10.1038/s41586-021-03756-0
https://doi.org/10.1038/s41586-021-03756-0
Autor:
Robin Vuilleumier, Mo Miao, Sonia Medina-Giro, Clara-Maria Ell, Stephane Flibotte, Tianshun Lian, Grant Kauwe, Annie Collins, Sophia Ly, George Pyrowolakis, A Pejmun Haghighi, Douglas W Allan
Publikováno v:
Nucleic acids research. 50(17)
Retrograde bone morphogenetic protein (BMP) signaling at the Drosophila neuromuscular junction (NMJ) has served as a paradigm to study TGF-β-dependent synaptic function and maturation. Yet, how retrograde BMP signaling transcriptionally regulates th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450f7edd187bb25998ae2478c94405b7
https://pubmed.ncbi.nlm.nih.gov/36029115
https://pubmed.ncbi.nlm.nih.gov/36029115