Zobrazeno 1 - 10
of 26
pro vyhledávání: '"A Paden King"'
Autor:
Meghan M. Bell, Nicholas T. Gutsche, A. Paden King, Kwamena E. Baidoo, Olivia J. Kelada, Peter L. Choyke, Freddy E. Escorcia
Publikováno v:
Molecules, Vol 26, Iss 1, p 4 (2020)
Glypican-3 (GPC3) is expressed in 75% of hepatocellular carcinoma (HCC), but not normal liver, making it a promising HCC therapeutic target. GC33 is a full-length humanized monoclonal IgG1 specific to GPC3 that can localize to HCC in vivo. GC33 alone
Externí odkaz:
https://doaj.org/article/e91f797894a9415aa0f6dfa7ebbad6a1
Autor:
Angelo Frei, Alysha G. Elliott, Alex Kan, Hue Dinh, Stefan Braese, Alice E. Bruce, Mitchell R. Bruce, Feng Chen, Dhirgam Humaidy, Nicole Jung, A. Paden King, Peter G. Lye, Hanna K. Maliszewska, Ahmed M. Mansour, Dimitris Matiadis, María Paz Muñoz, Tsung-Yu Pai, Shyam Pokhrel, Peter J. Sadler, Marina Sagnou, Michelle Taylor, Justin J. Wilson, Dean Woods, Johannes Zuegg, Wieland Meyer, Amy K. Cain, Matthew A. Cooper, Mark A. T. Blaskovich
There are currently fewer than ten antifungal drugs in clinical development, but new fungal strains, which are resistant to most current antifungals are spreading rapidly across the world. To prevent a second resistance crisis, new classes of antifun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197d3e4d3cc18221c5be926106578341
https://ueaeprints.uea.ac.uk/id/eprint/87077/
https://ueaeprints.uea.ac.uk/id/eprint/87077/
Autor:
Benjamin Neuditschko, A. Paden King, Zhouyang Huang, Lukas Janker, Andrea Bileck, Yasmin Borutzki, Sierra C. Marker, Christopher Gerner, Justin J. Wilson, Samuel M. Meier‐Menches
Publikováno v:
Angewandte Chemie. 134
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 49:7-17
The approval of 223RaCl2 for cancer therapy in 2013 has heralded a resurgence of interest in the development of α-particle emitting radiopharmaceuticals. In the last decade, over a dozen α-emitting radiopharmaceuticals have entered clinical trials,
Autor:
Karthika J. Kadassery, A. Paden King, Stanley Fayn, Kwamena E. Baidoo, Samantha N. MacMillan, Freddy E. Escorcia, Justin J. Wilson
Publikováno v:
Bioconjug Chem
Actinium-225 ((225)Ac) is one of the most promising radionuclides for targeted alpha therapy (TAT). With a half-life of 9.92 days and a decay chain that emits four high energy α particles, (225)Ac is well-suited for TAT when conjugated to macromolec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98039c378a050c2e874670c262eaeee7
https://europepmc.org/articles/PMC9362842/
https://europepmc.org/articles/PMC9362842/
Autor:
Angelo, Frei, Alysha G, Elliott, Alex, Kan, Hue, Dinh, Stefan, Bräse, Alice E, Bruce, Mitchell R, Bruce, Feng, Chen, Dhirgam, Humaidy, Nicole, Jung, A Paden, King, Peter G, Lye, Hanna K, Maliszewska, Ahmed M, Mansour, Dimitris, Matiadis, María Paz, Muñoz, Tsung-Yu, Pai, Shyam, Pokhrel, Peter J, Sadler, Marina, Sagnou, Michelle, Taylor, Justin J, Wilson, Dean, Woods, Johannes, Zuegg, Wieland, Meyer, Amy K, Cain, Matthew A, Cooper, Mark A T, Blaskovich
Publikováno v:
JACS Au
[Image: see text] There are currently fewer than 10 antifungal drugs in clinical development, but new fungal strains that are resistant to most current antifungals are spreading rapidly across the world. To prevent a second resistance crisis, new cla
Autor:
Joshua J. Woods, James H. Lovett, Zhouyang Huang, A. Paden King, Barry Lai, Hugh H. Harris, Justin J. Wilson
Publikováno v:
Chemical Communications. 57:11189-11192
The photophysical and photochemical properties of two Pt(IV)Re(I) conjugates were studied via both experimental and computational methods. Both conjugates exhibit modest photocytotoxicity against ovarian cancer cells. X-ray fluorescence microscopy sh
Autor:
Stanley Fayn, A. Paden King, Nicholas T. Gutsche, Zhijian Duan, Jesse Buffington, Colleen P. Olkowski, Ying Fu, Jessica Hong, Deepak Sail, Kwamena E. Baidoo, Rolf E. Swenson, Ross W. Cheloha, Mitchell Ho, Peter Choyke, Freddy Escorcia
Publikováno v:
Journal of Nuclear Medicine. :jnumed.122.265171
Autor:
Benjamin Neuditschko, A. Paden King, Zhouyang Huang, Lukas Janker, Andrea Bileck, Yasmin Borutzki, Sierra C. Marker, Christopher Gerner, Justin J. Wilson, Samuel M. Meier‐Menches
Target identification remains a critical challenge in inorganic drug discovery to deconvolute potential polypharmacology. Herein, we describe an improved approach to prioritize candidate protein targets based on a combination of dose-dependent chemop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708dd0f9fd4732d783b3ea7bcfc3f297
https://doi.org/10.1002/anie.202209136
https://doi.org/10.1002/anie.202209136
Autor:
Eszter Boros, Justin J. Wilson, A. Paden King, Robert V. Swanda, Brett A. Vaughn, Sierra C. Marker, Shu-Bing Qian
Publikováno v:
Angew Chem Weinheim Bergstr Ger
Angew Chem Int Ed Engl
Angew Chem Int Ed Engl
Rhenium tricarbonyl complexes have been recently investigated as novel anticancer agents. However, little is understood about their mechanisms of action, as well as the means by which cancer cells respond to chronic exposure to these compounds. To ga