The actions of methotrexate on endothelial cells are dependent on the shear stress-induced regulation of one carbon metabolism

Autor: Marie B. Lang, Kit-Yi Leung, Nicholas D.E. Greene, Kerri M. Malone, Gaye Saginc, Anna M. Randi, Allan Kiprianos, Robert T. Maughan, Charis Pericleous, Justin C. Mason

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

ObjectivesThe disease-modifying anti-rheumatic drug methotrexate (MTX) is recognized to reduce cardiovascular risk in patients with systemic inflammatory diseases. However, the molecular basis for these cardioprotective effects remains incompletely u

Externí odkaz: https://doaj.org/article/5d363a763a9c431a9c93d4a8e3417ea0

Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study

Autor: Sharon A. Chung, Gökhan Keser, Ayten Yazici, Zeynep Ozbalkan, R. Maughan, Servet Akar, Fatma Alibaz-Oner, Nurullah Akkoc, Kathleen McKinnon-Maksimowicz, Patrick Coit, Güher Saruhan-Direskeneli, Chris Wallace, Omer Karadag, Muge Bicakcigil, Antoine G. Sreih, Ahmet Mesut Onat, Paul A. Monach, Ying Sun, Kenan Aksu, Carol A. Langford, Mehmet Akif Ozturk, Izzet Fresko, Eren Erken, Lindsay Lally, Lindsy J. Forbess, Christian Pagnoux, Ayse Cefle, Ediz Dalkilic, Timothy J. Vyse, Veli Cobankara, Peter C. Grayson, Guillermo Reales, David Cuthbertson, Philip Seo, Gozde Yildirim Cetin, Curry L. Koening, Sibel P. Yentür, Yaşar Karaaslan, Lourdes Ortiz-Fernández, Nilufer Alpay-Kanitez, Bunyamin Kisacik, Xiufang Kong, Sibel Zehra Aydin, Enrico Tombetti, Sule Yavuz, Lindi Jiang, Fatos Onen, Allan P. Kiprianos, Nurşen Düzgün, Nader Khalidi, Justin C. Mason, Huiyong Chen, Aşkın Ateş, Angelo A. Manfredi, Murat Inanc, Sevil Kamali, Sema Kaymaz-Tahra, Steven R. Ytterberg, Timuçin Kaşifoğlu, Emire Seyahi, Elena Baldissera, Deborah S. Cunninghame-Graham, Sedat Kiraz, Jason M. Springer, Peter A. Merkel, Haner Direskeneli, Jonathan D. Wren, Kenneth J. Warrington, Carol A. McAlear, Amr H. Sawalha, Huseyin T. E. Ozer

Publikováno v: Am J Hum Genet

Takayasu arteritis is a rare inflammatory disease of large arteries. We performed a genetic study in Takayasu arteritis comprising 6,670 individuals (1,226 affected individuals) from five different populations. We discovered HLA risk factors and four

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa13832c2b14faa262d03689dbb58d8b
https://doi.org/10.1016/j.ajhg.2020.11.014

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A low balance between microparticles expressing tissue factor pathway inhibitor and tissue factor is associated with thrombosis in Behçet's Syndrome

Autor: E. Khan, N. L. Ambrose, J. Ahnström, A. P. Kiprianos, M. R. Stanford, D. Eleftheriou, P.A. Brogan, J. C. Mason, M. Johns, M. A. Laffan, D. O. Haskard

Publikováno v: Khan, E, Ambrose, N L, Ahnström, J, Kiprianos, A P, Stanford, M R, Eleftheriou, D, Brogan, P A, Mason, J C, Johns, M, Laffan, M A & Haskard, D O 2016, ' A low balance between microparticles expressing tissue factor pathway inhibitor and tissue factor is associated with thrombosis in Behçet's Syndrome ', Scientific Reports, vol. 6, 38104 . https://doi.org/10.1038/srep38104

Thrombosis is common in Behçet's Syndrome (BS), and there is a need for better biomarkers for risk assessment. As microparticles expressing Tissue Factor (TF) can contribute to thrombosis in preclinical models, we investigated whether plasma micropa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5305f8e107a25ad3c3e527a1ee3bb02e
https://kclpure.kcl.ac.uk/ws/files/62465411/A_low_balance_between_KHAN_Accepted_26OCT2016_GOLD_VoR_CCBY.pdf