Zobrazeno 1 - 10
of 63
pro vyhledávání: '"A O Y Luk"'
Autor:
Ke Wang, Mai Shi, Andrea O. Y. Luk, Alice P. S. Kong, Ronald C. W. Ma, Changhong Li, Li Chen, Elaine Chow, Juliana C. N. Chan
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-11 (2024)
Abstract Background Glucokinase (GK) plays a key role in glucose metabolism. In the liver, GK is regulated by GK regulatory protein (GKRP) with nuclear sequestration at low plasma glucose level. Some GK activators (GKAs) disrupt GK-GKRP interaction w
Externí odkaz:
https://doaj.org/article/ab74b99469fc4c329a175d4f6db6e49d
Autor:
Juliana N. M. Lui, Eric S. H. Lau, Aimin Yang, Hongjiang Wu, Amy Fu, Vanessa Lau, Kitman Loo, Theresa Yeung, Rebecca Yue, Ronald C. W. Ma, Alice P. S. Kong, Risa Ozaki, Andrea O. Y. Luk, Elaine Y. K. Chow, Juliana C. N. Chan
Publikováno v:
Journal of Diabetes, Vol 16, Iss 6, Pp n/a-n/a (2024)
Abstract Background Patients with type 2 diabetes (T2D) are at high risk of developing multiple complications, affecting their health‐related quality of life (HRQoL). Existing studies only considered impact of complication on HRQoL in the year of o
Externí odkaz:
https://doaj.org/article/ec52cf3431f449478f0f67ef06ebbcae
Autor:
Mai Shi, Aimin Yang, Eric S H Lau, Andrea O Y Luk, Ronald C W Ma, Alice P S Kong, Raymond S M Wong, Jones C M Chan, Juliana C N Chan, Elaine Chow
Publikováno v:
PLoS Medicine, Vol 21, Iss 4, p e1004369 (2024)
BackgroundOlder adults with diabetes are at high risk of severe hypoglycemia (SH). Many machine-learning (ML) models predict short-term hypoglycemia are not specific for older adults and show poor precision-recall. We aimed to develop a multidimensio
Externí odkaz:
https://doaj.org/article/2cc1b2e4f382441f9d1fce2c533d5ec8
Autor:
Jie He, Juliana C N Chan, Natural Chu, Ronald Ching Wan Ma, Alice Pik Shan Kong, Baoqi Fan, Eric S H Lau, Noel Yat Hey Ng, Kathy Ho Ting Leung, Emily W M Poon, Andrea O Y Luk, Elaine Chow
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 12, Iss 1 (2024)
Introduction Type 2 diabetes is preventable in subjects with impaired glucose tolerance based on 2-hour plasma glucose (2hPG) during 75 g oral glucose tolerance test (OGTT). We incorporated routine biochemistry to improve the performance of a non-inv
Externí odkaz:
https://doaj.org/article/048c9ac05f7f46b28d1a23a95c53beca
Autor:
Hongjiang Wu, Aimin Yang, Eric S H Lau, Xinge Zhang, Baoqi Fan, Ronald C W Ma, Alice P S Kong, Elaine Chow, Wing-Yee So, Juliana C N Chan, Andrea O Y Luk
Publikováno v:
PLoS Medicine, Vol 21, Iss 1, p e1004327 (2024)
BackgroundClinical trials have demonstrated that remission of type 2 diabetes can be achieved following sustained weight loss. However, the feasibility of achieving diabetes remission through weight management in real-world settings remains unclear.
Externí odkaz:
https://doaj.org/article/8216dab3b118416dbe3c688129faa33c
Autor:
Lim, Lee-Ling, S. H. Lau, Eric, Pheng Chan, Siew, Ji, Linong, Lim, Soo, Sirinvaravong, Sirinart, Unnikrishnan, A.G., O. Y. Luk, Andrea, Cortese, Viviana, Durocher, Alexandra, C. N. Chan, Juliana
Publikováno v:
In Diabetes Research and Clinical Practice September 2023 203
Autor:
Ke Wang, Mai Shi, Chuiguo Huang, Baoqi Fan, Andrea O. Y. Luk, Alice P. S. Kong, Ronald C. W. Ma, Juliana C. N. Chan, Elaine Chow
Publikováno v:
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-10 (2022)
Abstract Background Glucokinase activators (GKAs) are an emerging class of glucose lowering drugs that activate the glucose-sensing enzyme glucokinase (GK). Pending formal cardiovascular outcome trials, we applied two-sample Mendelian randomisation (
Externí odkaz:
https://doaj.org/article/693ad199c83d4c29af9f951a9c3f7904
Autor:
Johnny T. K. Cheung, Eric Lau, Cyrus C. T. Tsui, Edmond L. N. Siu, Naomi K. W. Tse, Nicole Y. L. Hui, Ronald C. W. Ma, Alice P. S. Kong, Amy Fu, Vanessa Lau, Weiping Jia, Wayne H. H. Sheu, Leorino Sobrepena, K. H. Yoon, Alexander T. B. Tan, Yook-Chin Chia, Aravind Sosale, Banshi D. Saboo, Jothydev Kesavadev, Su-Yen Goh, Thy Khue Nguyen, Yotsapon Thewjitcharoen, Raymond Suwita, Andrea O. Y. Luk, Aimin Yang, Elaine Chow, Lee Ling Lim, Juliana C. N. Chan
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background Family history (FamH) of type 2 diabetes might indicate shared genotypes, environments, and/or behaviors. We hypothesize that FamH interacts with unhealthy behaviors to increase the risk of early onset of diabetes and poor cardiom
Externí odkaz:
https://doaj.org/article/e7cf398038654d21a12430ab2b8992b6
Autor:
Hongjiang Wu, Eric S H Lau, Aimin Yang, Xinge Zhang, Baoqi Fan, Ronald C W Ma, Alice P S Kong, Elaine Chow, Wing-Yee So, Juliana C N Chan, Andrea O Y Luk
Publikováno v:
PLoS Medicine, Vol 20, Iss 1, p e1004173 (2023)
BackgroundThe prevalence of type 2 diabetes has increased in both young and old people. We examined age-specific associations and population attributable fractions (PAFs) of risk factors for all-cause and cause-specific mortality in people with type
Externí odkaz:
https://doaj.org/article/b8db79eeae34434e906cf18be705a80d
Autor:
Xinge Zhang, Hongjiang Wu, Baoqi Fan, Mai Shi, Eric S H Lau, Aimin Yang, Elaine Chow, Alice P S Kong, Juliana C N Chan, Ronald C W Ma, Andrea O Y Luk
Publikováno v:
PLoS Medicine, Vol 19, Iss 7, p e1004045 (2022)
BackgroundLittle is known about the lifetime risk of progression to diabetes in the Asian population. We determined remaining lifetime risk of diabetes and life years spent with diabetes in Chinese people with normoglycemia and prediabetes.Methods an
Externí odkaz:
https://doaj.org/article/8c4bb1931b184d409b6ab1dde67a5961