Výsledky vyhledávání - "A O, Viglinskaia"

[Pharmacokinetics of afobazole metabolite (M-11) in rats]

Autor: D V, Bastrygin, A O, Viglinskaia, G B, Kolyvanov, A A, Litvin, P O, Bochkov, T Ia, Mozhaeva, V P, Zherdev

Publikováno v: Eksperimental'naia i klinicheskaia farmakologiia. 74(7)

Pharmacokinetics of compound M-11 (main metabolite of afobazole) after administration via different routes was studied in rats. After oral and intravenous administration, M-11 exhibited weakly pronounced bioconversion with the formation of a few meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a9b01f9b1364cc7020e86a02f58e4d2f
https://pubmed.ncbi.nlm.nih.gov/21894764

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[Model study of afobazole distribution in pregnant and lactating female rats and infant rat pups]

Autor: O V, Shreder, G B, Kolyvanov, A A, Litvin, D V, Bastrygin, E D, Shreder, A S, Solomina, A O, Viglinskaia, V V, Zabrodina, V P, Zherdev, A D, Durnev, S B, Seredenin

Publikováno v: Eksperimental'naia i klinicheskaia farmakologiia. 73(8)

Afobazole and M-11, its major metabolite were detected in placental and embryonic rat tissues after single peroral administration to pregnant female rats at a dose of 100 mg/kg. The anxiolytic drug and its metabolite are also detected in rat milk and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9e3e15099543c92e26a3aab2e7e7c55f
https://pubmed.ncbi.nlm.nih.gov/20919552

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[Comparative pharmacokinetics of dihydroquercetin in rats upon peroral administration of a parent compound and liposomal flamen D]

Autor: V P, Zherdev, G B, Kolyvanov, A A, Litvin, A K, Sariev, A O, Viglinskaia, B I, Gekkiev, A M, Grigor'ev, V V, Gorlov

Publikováno v: Eksperimental'naia i klinicheskaia farmakologiia. 73(1)

The pharmacokinetics of dihydroquercetin (DHQ) in the forms of parent substance and a new liposomal formulation (Flamena D) have been studied in rats upon single peroral administration in a dose of 50 mg/kg. DHQ concentration after enzymatic hydrolys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbaf559591a36d232b53bbaf4cb69014
https://pubmed.ncbi.nlm.nih.gov/20184284

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[Afobazole metabolism in rats]

Autor: S B, Seredenin, A O, Viglinskaia, T Ia, Mozhaeva, G B, Kolyvanov, A A, Litvin, N I, Avdiunina, V L, Savel'ev, V P, Zgerdev

Publikováno v: Eksperimental'naia i klinicheskaia farmakologiia. 71(2)

Metabolism of afobazole in rats has been studied using mass-spectrometry and HPLC, which revealed 17 products of afobazole biotransformation along with the parent compound. The structures of six afobazole metabolites were established and confirmed by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a6680e70ab319af792986d66dd26adb8
https://pubmed.ncbi.nlm.nih.gov/18488909

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[Pharmacokinetics of afobazole in rats]

Autor: S B, Seredenin, A O, Viglinskaia, G B, Kolyvanov, A A, Litvin, O Iu, Kravtsova, V P, Zherdev

Publikováno v: Eksperimental'naia i klinicheskaia farmakologiia. 70(2)

Afobazole pharmacokinetics was studied after the administration via different ways in rats. After oral administration, afobazole is subject to intensive biotransformation with the formation of several metabolites (M-6, M-7, and M-11). The drug and it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e217feab533bfbb910e1507a40eb149a
https://pubmed.ncbi.nlm.nih.gov/17523455

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