Zobrazeno 1 - 10
of 64
pro vyhledávání: '"A O, Bryzgalov"'
Autor:
Yulia E. Tomilova, Nikolay E. Russkikh, Igor M. Yi, Elizaveta V. Shaburova, Viktor N. Tomilov, Galina B. Pyrinova, Svetlana O. Brezhneva, Olga S. Tikhonyuk, Nadezhda S. Gololobova, Dmitriy V. Popichenko, Maxim O. Arkhipov, Leonid O. Bryzgalov, Evgeniy V. Brenner, Anastasia A. Artyukh, Dmitry N. Shtokalo, Denis V. Antonets, Mikhail K. Ivanov
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
IntroductionModification of natural enzymes to introduce new properties and enhance existing ones is a central challenge in bioengineering. This study is focused on the development of Taq polymerase mutants that show enhanced reverse transcriptase (R
Externí odkaz:
https://doaj.org/article/04fb173ce4b54ce4bab50ac987e3ac1d
The functional insight into the genetics of cardiovascular disease: results from the post-GWAS study
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 26, Iss 1, Pp 65-73 (2022)
Cardiovascular diseases (CVDs), the leading cause of death worldwide, generally refer to a range of pathological conditions with the involvement of the heart and the blood vessels. A sizable fraction of the susceptibility loci is known, but the under
Externí odkaz:
https://doaj.org/article/62ec5aaac37248f49791eaf568fe776a
Autor:
Kirill P. Cheremnykh, Arkadiy O. Bryzgalov, Dmitry S. Baev, Sergey A. Borisov, Yulia S. Sotnikova, Victor A. Savelyev, Tatyana G. Tolstikova, Shamansur S. Sagdullaev, Elvira E. Shults
Publikováno v:
Molecules, Vol 28, Iss 10, p 4234 (2023)
Diterpenoid alkaloids, originating from the amination of natural tetracyclic diterpenes, have long interested scientists due to their medicinal uses and infamous toxicity which has limited the clinical application of the native compound. Alkaloid lap
Externí odkaz:
https://doaj.org/article/3287ddae6ee24a06a3d5bae10f9f428c
Autor:
Elena O. Shestakova, Sergey G. Il’yasov, Irina A. Shchurova, Vera S. Glukhacheva, Dmitri S. Il’yasov, Egor E. Zhukov, Arkady O. Bryzgalov, Tatiana G. Tolstikova, Yuri V. Gatilov
Publikováno v:
Pharmaceuticals, Vol 15, Iss 12, p 1443 (2022)
Here, we investigated the reaction of 1,3-dipolar cycloaddition of 1,3-diazido-2-nitro-2- azapropane (DANP) to propargyl alcohol over a copper-based catalyst and identified the optimum reaction conditions that enable the synthesis of 2-nitro-1,3-bis(
Externí odkaz:
https://doaj.org/article/31882c93d32f44fa9832dcfe78f45026
Autor:
Leonid O. Bryzgalov, Elena E. Korbolina, Ilja I. Brusentsov, Elena Y. Leberfarb, Natalia P. Bondar, Tatiana I. Merkulova
Publikováno v:
BMC Neuroscience, Vol 19, Iss S1, Pp 41-56 (2018)
Abstract Background A challenge of understanding the mechanisms underlying cognition including neurodevelopmental and neuropsychiatric disorders is mainly given by the potential severity of cognitive disorders for the quality of life and their preval
Externí odkaz:
https://doaj.org/article/12cbdc1364a0445baf9ef0731b24a273
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 20, Iss 6, Pp 797-803 (2017)
A new approach to the search for regulatory SNPs (rSNPs) based on the use of ENCODE project data on ChIP-seq and RNA-seq experiments was developed. The approach was successfully used for the detection of rSNPs associated with colorectal cancer suscep
Externí odkaz:
https://doaj.org/article/0d048e3a7df045598b9284d548352625
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 7955
Alzheimer’s disease (AD) is a prevalent type of dementia in elderly populations with a significant genetic component. The accumulating evidence suggests that AD involves a reconfiguration of the epigenetic landscape, including DNA methylation, post
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3874d1d52e2e80d96903f10b0928811
Epigenetic «probes» for lung cancer monitoring: LINE-1 methylation pattern in blood- circulating DNA
Autor:
A. A. Ponomaryova, Е. Y. Rykova, N. V. Cherdyntseva, A. A. Bondar, A. Y. Dobrodeev, A. A. Zavyalov, S. A. Tuzikov, L. O. Bryzgalov, T. I. Merkulova, V. V. Vlassov, P. P. Laktionov
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 19, Iss 1, Pp 144-150 (2015)
Malignant cell transformation is accompanied by two processes of DNA methylation changes: promoter hypermethylation of specific genes and hypomethylation of retrotransposons. The composition of circulating DNA (cirDNA) from plasma and cell-surface-bo
Externí odkaz:
https://doaj.org/article/f4b173a92e4c468e9f12fce41c614e52
Autor:
D. A. Rasskazov, E. V. Antontseva, L. O. Bryzgalov, M. Yu. Matveeva, E. V. Kashina, P. M. Ponomarenko, G. V. Orlova, M. P. Ponomarenko, D. A. Afonnikov, T. I. Merkulova
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 17, Iss 4/1, Pp 589-598 (2015)
Six regulatory SNPs (single nucleotide polymorphisms) of two human APC and MLH1 genes (rs75996864, rs76241113, rs78037487, rs80112297, rs80313086 and rs1800734) were evaluated by the previously developed rSNP_Guide method to compute the significance
Externí odkaz:
https://doaj.org/article/1b28ae2cf65e4cadac16d69f85658156
Autor:
N. L. Podkolodnyy, D. A. Afonnikov, Yu. Yu. Vaskin, L. O. Bryzgalov, V. A. Ivanisenko, P. S. Demenkov, M. P. Ponomarenko, D. A. Rasskazov, K. V. Gunbin, I. V. Protsyuk, I. Yu. Shutov, P. N. Leontyev, M. Yu. Fursov, N. P. Bondar, E. V. Antontseva, T. I. Merkulova, N. A. Kolchanov
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 17, Iss 4/1, Pp 577-588 (2015)
This paper describes the SNP-MED modular computer-based information system for estimation of the influence of single nucleotide polymorphisms (SNPs) on the function of genes associated with the risk of socially significant diseases. The system includ
Externí odkaz:
https://doaj.org/article/3ce6fa2886c241ecb37e39dd0363cf4e