Randomised, open-label, multicentric phase III trial to evaluate the safety and efficacy of palbociclib in combination with endocrine therapy, guided by ESR1 mutation monitoring in oestrogen receptor-positive, HER2-negative metastatic breast cancer patients: study design of PADA-1

Autor: C Cheneau, S Barthier, J Lemonnier, Fabrice Andre, C Dubot, L Teixeira, A Escande, T De La Motte Rouge, T Petit, L Arnould, Laurent Arnould, Suzette Delaloge, Jerome Lemonnier, A Marti, L Stefani, F Berger, C Levy, P Barthelemy, S Nguyen, M Gardner, A Lortholary, François-Clément Bidard, J Plaza, L Joly, Thibault de la Motte Rouge, F Andre, I Bièche, C Alleaume, R Sabatier, B Lucas, Ivan Bieche, O Derbel, L Venat-Bouvet, F Del Piano, Florian Clatot, Anne-Claire Hardy-Bessard, Frédérique Berger, Margaux Marce, Thomas Bachelot, Anne Pradines, Jean-Luc Canon, Sandrine Marques, M Achille, H Ammarguellat, O Arsene, T Bachelot, C Bernard-Marty, F-C Bidard, N Bonichon-Lamichhane, N Bonnin, R Bouaita, A Boudrant, V-A Brunel, C Chakiba, F Clatot, F Dalenc, A De Gramont, L Deiana, C Delbaldo, V Delecroix, H Desclos, V D'Hondt, N Dohollou, J-M Ferrero, C Foa, J-S Frenel, C Garnier Tixidre, D Genet, O Gisserot, M Gozy, C Greilsamer, J Grenier, F Guinet, A-C Hardy-Bessard, J-P Jacquin, E Lachaier, S Ladoire, A-P Laurenty, R Le Scodan, N Leduc, E Legouffe, C Levache, F Lorchel, N Marques, J Medioni, A Melis, D Mille, D Mollon, L Moreau, I Moullet, M-A Mouret-Reynier, A Najem, H Orfeuvre, J-F Paitel, B Pistilli, C Riedl, P Soulie, D Spaeth, F Trouboul, C Valmar, H Vegas, A Zannetti, FC Bidard, S Delaloge, A Pradines, JL Canon, S Marques

Publikováno v: BMJ Open, Vol 12, Iss 3 (2022)

Introduction The combination of a CDK4/6 inhibitor with an aromatase inhibitor (AI) has recently become the gold standard for AI-sensitive first line treatment of oestrogen receptor-positive (ER+) HER2-negative (HER2−) advanced breast cancer. Howev

Externí odkaz: https://doaj.org/article/8faf6bbc845f4ceeb90674dd08e198da

Black Hole in Discrete Gravity

Autor: Chamseddine, Ali H., Malaeb, Ola, Najem, Sara

We study the metric corresponding to a three-dimensional coset space $SO(4)/SO(3)$ in the lattice setting. With the use of three integers $n_1, n_2$, and $n_3$, and a length scale, $l_{\mu}$, the continuous metric is transformed into a discrete space

Externí odkaz: http://arxiv.org/abs/2311.00406

Biomembrane-based Memcapacitive Reservoir Computing System for Energy Efficient Temporal Data Processing

Autor: Hossain, Md Razuan, Mohamed, Ahmed Salah, Armendarez, Nicholas Xavier, Najem, Joseph S., Hasan, Md Sakib

Reservoir computing is a highly efficient machine learning framework for processing temporal data by extracting features from the input signal and mapping them into higher dimensional spaces. Physical reservoir layers have been realized using spintro

Externí odkaz: http://arxiv.org/abs/2305.12025

Page Layout Analysis of Text-heavy Historical Documents: a Comparison of Textual and Visual Approaches

Autor: Sven, Najem-Meyer, Matteo, Romanello

Publikováno v: Proceedings of the Computational Humanities Research Conference 2022

Page layout analysis is a fundamental step in document processing which enables to segment a page into regions of interest. With highly complex layouts and mixed scripts, scholarly commentaries are text-heavy documents which remain challenging for st

Externí odkaz: http://arxiv.org/abs/2212.13924

Harnessing blue light for cost-effective and eco-friendly antimicrobial solutions in poultry farming.

Autor: Al-Tameemi, Hassan M.¹ hisan.jasim@uobasrah.edu.iq, Najem, Harith Abdulla², Nasear, Hiba A.³, Abbas, Basil A.¹

Publikováno v: Korean Journal of Veterinary Research. Sep2024, Vol. 64 Issue 3, p1-8. 8p.