Zobrazeno 1 - 10
of 76
pro vyhledávání: '"A N-Y Cheung"'
Autor:
Aaron H. Y. Chan, Siew-Fei Ngu, Lesley S. K. Lau, Obe K. L. Tsun, Hextan Y. S. Ngan, Annie N. Y. Cheung, Karen K. L. Chan
Publikováno v:
Diagnostics, Vol 13, Iss 21, p 3297 (2023)
This study aimed to evaluate the concordance of HPV results between the SentisTM HPV assay (Sentis) (BGI Group, Shenzhen, China), an isothermal amplification-based HPV assay, on self-collected and clinician-collected samples and the agreement of Sent
Externí odkaz:
https://doaj.org/article/21471ceaa29a410c9d84a42f299e02a8
Autor:
Jing Li, Ruiqin Wu, Mingo M. H. Yung, Jing Sun, Zhuqing Li, Hai Yang, Yi Zhang, Stephanie S. Liu, Annie N. Y. Cheung, Hextan Y. S. Ngan, John C. Braisted, Wei Zheng, Huiqiang Wei, Yingtang Gao, Peter Nemes, Huadong Pei, David W. Chan, Yiliang Li, Wenge Zhu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Abstract The JAK2/STAT pathway is hyperactivated in many cancers, and such hyperactivation is associated with a poor clinical prognosis and drug resistance. The mechanism regulating JAK2 activity is complex. Although translocation of JAK2 between nuc
Externí odkaz:
https://doaj.org/article/2b4ae799d7e74199b3f6285cc808595b
Autor:
Ling Rao, Victor C. Y. Mak, Yuan Zhou, Dong Zhang, Xinran Li, Chloe C. Y. Fung, Rakesh Sharma, Chao Gu, Yiling Lu, George L. Tipoe, Annie N. Y. Cheung, Gordon B. Mills, Lydia W. T. Cheung
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
p85β (PIK3R2), a regulatory subunit of PI3K, has oncogenic properties. Here the authors show that p85β promotes AXL protein stability, which in turn activates p110 to induce PDK1/SGK3 signaling, and therapeutically, p85β-expressing ovarian cancer
Externí odkaz:
https://doaj.org/article/adc6777a01c94b29a362d31af3cc89e0
Autor:
Yu-xin Jiang, Michelle K. Y. Siu, Jing-jing Wang, Thomas H. Y. Leung, David W. Chan, Annie N. Y. Cheung, Hextan Y. S. Ngan, Karen K. L. Chan
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Glycolysis has been reported to be critical for cancer stem cells (CSCs), which are associated with tumor chemoresistance, metastasis and recurrence. Thus, selectively targeting glycolytic enzymes may be a potential therapy for ovarian cancer. 6‐ph
Externí odkaz:
https://doaj.org/article/4792fb00367c476d9bcc9a863a9f060b
Autor:
Stephanie S Liu, Karen K L Chan, Tina N Wei, Ka Yu Tse, Siew F Ngu, Mandy M Y Chu, Lesley S K Lau, Annie N Y Cheung, Hextan Y S Ngan
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0272721 (2022)
High-risk human papillomavirus (HR-HPV) testing has become an increasing important strategy in primary cervical cancer screening in recent years. It warrants the evaluation of molecular-based HPV tests for accuracy and efficacy of screening. The perf
Externí odkaz:
https://doaj.org/article/66619662a83448e79ba10ecd3fd83a4f
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Ovarian clear cell carcinoma (OCCC) is one of the major types of ovarian cancer and is of higher relative prevalence in Asians. It also shows higher possibility of resistance to cisplatin-based chemotherapy leading to poor prognosis. This may be attr
Externí odkaz:
https://doaj.org/article/ce8a16db2a8d40ec9066ae44b2b63879
Autor:
Xinran Li, Victor C. Y. Mak, Yuan Zhou, Chao Wang, Esther S. Y. Wong, Rakesh Sharma, Yiling Lu, Annie N. Y. Cheung, Gordon B. Mills, Lydia W. T. Cheung
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Loss of PIK3R1 in ovarian cancer is a common event, which provides opportunities for therapeutic intervention. Here, the authors show that the STAT3 and AKT signaling pathways are activated upon PIK3R1 loss and that, in mice, inhibitors of these path
Externí odkaz:
https://doaj.org/article/85e4150d1ad2485d83cd05457232c1ef
Autor:
Stephanie S. Liu, Karen K. L. Chan, Daniel K. H. Chu, Tina N. Wei, Lesley S. K. Lau, Siew F. Ngu, Mandy M. Y. Chu, Ka Yu Tse, Philip P. C. Ip, Enders K. O. Ng, Annie N. Y. Cheung, Hextan Y. S. Ngan
Publikováno v:
Molecular Oncology, Vol 12, Iss 12, Pp 2009-2022 (2018)
Cervical cancer is one of the leading causes of cancer death in women globally, despite the widespread use of cytology/human papillomavirus (HPV) screening. In the present study, we aimed to identify the potential role of microRNA (miRNA) as a diagno
Externí odkaz:
https://doaj.org/article/3bc6c656406443fda7b1518314a5bd93
Autor:
Maggie K. S. Tang, Patrick Y. K. Yue, Philip P. Ip, Rui-Lan Huang, Hung-Cheng Lai, Annie N. Y. Cheung, Ka Yu Tse, Hextan Y. S. Ngan, Alice S. T. Wong
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
A soluble form E-cadherin is highly expressed in ovarian cancer. Here, the authors show that soluble E-cadherin is released by ovarian cancer cells packaged in exosomes and promotes tumor angiogenesis through β-catenin and NFkB signaling activation.
Externí odkaz:
https://doaj.org/article/599dda1639f747589df0acf5f4d2b966
Autor:
Raymond Boon Tar Lim, Olive N. Y. Cheung, Dede Kam Tyng Tham, Hanh Hao La, Thein Than Win, Roy Chan, Mee Lian Wong
Publikováno v:
Globalization and Health, Vol 14, Iss 1, Pp 1-12 (2018)
Abstract Background There is an increasing global movement of foreign female entertainment workers (FEWs), a hard-to-reach population vulnerable to HIV/STIs. This paper described the needs assessment phase before intervention implementation where the
Externí odkaz:
https://doaj.org/article/5b8a80b49cac497fbee20311349c6b04