PRISM: Patient Records Interpretation for Semantic clinical trial Matching system using large language models

Autor: Shashi Gupta, Aditya Basu, Mauro Nievas, Jerrin Thomas, Nathan Wolfrath, Adhitya Ramamurthi, Bradley Taylor, Anai N. Kothari, Regina Schwind, Therica M. Miller, Sorena Nadaf-Rahrov, Yanshan Wang, Hrituraj Singh

Publikováno v: npj Digital Medicine, Vol 7, Iss 1, Pp 1-12 (2024)

Abstract Clinical trial matching is the task of identifying trials for which patients may be eligible. Typically, this task is labor-intensive and requires detailed verification of patient electronic health records (EHRs) against the stringent inclus

Externí odkaz: https://doaj.org/article/182275fd80c34579831829800e2db4cd

Epigallocatechin-3-Gallate Upregulates miR-221 to Inhibit Osteopontin-Dependent Hepatic Fibrosis.

Autor: M L Arffa, M A Zapf, A N Kothari, V Chang, G N Gupta, X Ding, M M Al-Gayyar, W Syn, N M Elsherbiny, P C Kuo, Z Mi

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0167435 (2016)

Osteopontin (OPN) promotes hepatic fibrosis, and developing therapies targeting OPN expression in settings of hepatic injury holds promise. The polyphenol epigallocatechin-3-gallate (EGCG), found in high concentrations in green tea, downregulates OPN

Externí odkaz: https://doaj.org/article/a38e725762c34795a77acb3073ecf838

Nonelective coronary artery bypass graft outcomes are adversely impacted by Coronavirus disease 2019 infection, but not altered processes of care: A National COVID Cohort Collaborative and National Surgery Quality Improvement Program analysisCentral MessagePerspective

Autor: Emily A. Grimsley, MD, Johnathan V. Torikashvili, BS, Haroon M. Janjua, MS, Meagan D. Read, MD, Anai N. Kothari, MD, MS, Nate B. Verhagen, BS, Ricardo Pietrobon, MD, PhD, Paul C. Kuo, MD, MS, MBA, Michael P. Rogers, MD, MS, Adam B. Wilcox, Adam M. Lee, Alexis Graves, Alfred (Jerrod) Anzalone, Amin Manna, Amit Saha, Amy Olex, Andrea Zhou, Andrew E. Williams, Andrew Southerland, Andrew T. Girvin, Anita Walden, Anjali A. Sharathkumar, Benjamin Amor, Benjamin Bates, Brian Hendricks, Brijesh Patel, Caleb Alexander, Carolyn Bramante, Cavin Ward-Caviness, Charisse Madlock-Brown, Christine Suver, Christopher Chute, Christopher Dillon, Chunlei Wu, Clare Schmitt, Cliff Takemoto, Dan Housman, Davera Gabriel, David A. Eichmann, Diego Mazzotti, Don Brown, Eilis Boudreau, Elaine Hill, Elizabeth Zampino, Emily Carlson Marti, Emily R. Pfaff, Evan French, Farrukh M. Koraishy, Federico Mariona, Fred Prior, George Sokos, Greg Martin, Harold Lehmann, Heidi Spratt, Hemalkumar Mehta, Hongfang Liu, Hythem Sidky, J.W. Awori Hayanga, Jami Pincavitch, Jaylyn Clark, Jeremy Richard Harper, Jessica Islam, Jin Ge, Joel Gagnier, Joel H. Saltz, Joel Saltz, Johanna Loomba, John Buse, Jomol Mathew, Joni L. Rutter, Julie A. McMurry, Justin Guinney, Justin Starren, Karen Crowley, Katie Rebecca Bradwell, Kellie M. Walters, Ken Wilkins, Kenneth R. Gersing, Kenrick Dwain Cato, Kimberly Murray, Kristin Kostka, Lavance Northington, Lee Allan Pyles, Leonie Misquitta, Lesley Cottrell, Lili Portilla, Mariam Deacy, Mark M. Bissell, Marshall Clark, Mary Emmett, Mary Morrison Saltz, Matvey B. Palchuk, Melissa A. Haendel, Meredith Adams, Meredith Temple-O'Connor, Michael G. Kurilla, Michele Morris, Nabeel Qureshi, Nasia Safdar, Nicole Garbarini, Noha Sharafeldin, Ofer Sadan, Patricia A. Francis, Penny Wung Burgoon, Peter Robinson, Philip R.O. Payne, Rafael Fuentes, Randeep Jawa, Rebecca Erwin-Cohen, Rena Patel, Richard A. Moffitt, Richard L. Zhu, Rishi Kamaleswaran, Robert Hurley, Robert T. Miller, Saiju Pyarajan, Sam G. Michael, Samuel Bozzette, Sandeep Mallipattu, Satyanarayana Vedula, Scott Chapman, Shawn T. O'Neil, Soko Setoguchi, Stephanie S. Hong, Steve Johnson, Tellen D. Bennett, Tiffany Callahan, Umit Topaloglu, Usman Sheikh, Valery Gordon, Vignesh Subbian, Warren A. Kibbe, Wenndy Hernandez, Will Beasley, Will Cooper, William Hillegass, Xiaohan Tanner Zhang

Publikováno v: JTCVS Open, Vol 16, Iss , Pp 342-352 (2023)

Objective: The effects of Coronavirus disease 2019 (COVID-19) infection and altered processes of care on nonelective coronary artery bypass grafting (CABG) outcomes remain unknown. We hypothesized that patients with COVID-19 infection would have long

Externí odkaz: https://doaj.org/article/21efb68f029e459093a6ac34c9f6ea42

Patient similarity and other artificial intelligence machine learning algorithms in clinical decision aid for shared decision-making in the Prevention of Cardiovascular Toxicity (PACT): a feasibility trial design

Autor: Sherry-Ann Brown, Brian Y. Chung, Krishna Doshi, Abdulaziz Hamid, Erin Pederson, Ragasnehith Maddula, Allen Hanna, Indrajit Choudhuri, Rodney Sparapani, Mehri Bagheri Mohamadi Pour, Jun Zhang, Anai N. Kothari, Patrick Collier, Pedro Caraballo, Peter Noseworthy, Adelaide Arruda-Olson, for the Cardio-Oncology Artificial Intelligence Informatics and Precision Equity (CAIPE) Research Team Investigators

Publikováno v: Cardio-Oncology, Vol 9, Iss 1, Pp 1-10 (2023)

Abstract Background The many improvements in cancer therapies have led to an increased number of survivors, which comes with a greater risk of consequent/subsequent cardiovascular disease. Identifying effective management strategies that can mitigate

Externí odkaz: https://doaj.org/article/b26d5d15ae0c4ce999952205f414e93b

Adherence to safety precautions in the operation theatre among anaesthesiologists in the COVID era

Autor: M Karthik Jain, Deepa Baskaran, Sathyanarayan Jagannath, Apoorwa N Kothari, Ramesh Arumugam, Sumithra Selvam

Publikováno v: Indian Journal of Anaesthesia, Vol 66, Iss 12, Pp 854-860 (2022)

Background and Aims: The COVID-19 pandemic led to significant infections among healthcare workers and deaths warranting the need for personal protective equipment. This study aimed to estimate the proportion of anaesthesiologists adhering to safety p

Externí odkaz: https://doaj.org/article/43adb6c9e2b9465eb219e9e86e583153