Zobrazeno 1 - 10
of 263
pro vyhledávání: '"A N J McKenzie"'
Autor:
Paula A. Clark, Mayuri Gogoi, Noe Rodriguez-Rodriguez, Ana C. F. Ferreira, Jane E. Murphy, Jennifer A. Walker, Alastair Crisp, Helen E. Jolin, Jacqueline D. Shields, Andrew N. J. McKenzie
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Innate lymphoid cells (ILCs) are critical in maintaining tissue homeostasis, and during infection and inflammation. Here we identify, by using combinatorial reporter mice, a rare ILC progenitor (ILCP) population, resident to the small intest
Externí odkaz:
https://doaj.org/article/c71615789fe8474da7ea50ebd878945a
Autor:
Emilie J. Cosway, Kieran D. James, Andrea J. White, Sonia M. Parnell, Andrea Bacon, Andrew N. J. McKenzie, W. E. Jenkinson, Graham Anderson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract As the primary site of T-cell development, the thymus dictates immune competency of the host. The rates of thymus function are not constant, and thymus regeneration is essential to restore new T-cell production following tissue damage from e
Externí odkaz:
https://doaj.org/article/2f6fc6882f6e4f17b1ea21f1939791f2
Autor:
Yuanyuan Zhang, Tianxiao Liu, Zhiyong Deng, Wenqian Fang, Xian Zhang, Shuya Zhang, Minjie Wang, Songyuan Luo, Zhaojie Meng, Jing Liu, Galina K. Sukhova, Dazhu Li, Andrew N. J. McKenzie, Peter Libby, Guo‐Ping Shi, Junli Guo
Publikováno v:
Advanced Science, Vol 10, Iss 7, Pp n/a-n/a (2023)
Abstract Development of abdominal aortic aneurysms (AAA) enhances lesion group‐2 innate lymphoid cell (ILC2) accumulation and blood IL5. ILC2 deficiency in Rorafl/flIl7rCre/+ mice or induced ILC2 depletion in Icosfl‐DTR‐fl/+Cd4Cre/+ mice expedi
Externí odkaz:
https://doaj.org/article/5088f16849cc46d4b5b3ce3f82354472
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide, and is largely refractory to current immunotherapeutic interventions. The lack of efficacy of existing cancer immunotherapies in CRC reflects the complex nature of
Externí odkaz:
https://doaj.org/article/b538b4fca4d94628bc9851ad26690b39
Autor:
Laurence S. C. Lok, Jennifer A. Walker, Helen E. Jolin, Seth T. Scanlon, Masaru Ishii, Padraic G. Fallon, Andrew N. J. McKenzie, Menna R. Clatworthy
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Group 2 innate lymphoid cells (ILC2s) are early effectors of mucosal type 2 immunity, producing cytokines such as interleukin (IL)-13 to mediate responses to helminth infection and allergen-induced inflammation. ILC2s are also present in lymph nodes
Externí odkaz:
https://doaj.org/article/2c7b2790aff8439283a064b67e45a006
Autor:
Liora Haim-Vilmovsky, Johan Henriksson, Jennifer A Walker, Zhichao Miao, Eviatar Natan, Gozde Kar, Simon Clare, Jillian L Barlow, Evelina Charidemou, Lira Mamanova, Xi Chen, Valentina Proserpio, Jhuma Pramanik, Steven Woodhouse, Anna V Protasio, Mirjana Efremova, Julian L Griffin, Matt Berriman, Gordon Dougan, Jasmin Fisher, John C Marioni, Andrew N J McKenzie, Sarah A Teichmann
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251233 (2021)
The transcription factor Rora has been shown to be important for the development of ILC2 and the regulation of ILC3, macrophages and Treg cells. Here we investigate the role of Rora across CD4+ T cells in general, but with an emphasis on Th2 cells, b
Externí odkaz:
https://doaj.org/article/3d39463ca138487e88bb41bb5b120a66
Autor:
Aydan C. H. Szeto, Ana C. F. Ferreira, Jonathan Mannion, Paula A. Clark, Meera Sivasubramaniam, Morgan W. D. Heycock, Alastair Crisp, Helen E. Jolin, Patrycja Kozik, Martin D. Knolle, Andrew N. J. McKenzie
Publikováno v:
Nature Immunology. 24:123-135
Naive CD4+ T lymphocytes initially undergo antigen-specific activation to promote a broad-spectrum response before adopting bespoke cytokine expression profiles shaped by intercellular microenvironmental cues, resulting in pathogen-focused modular cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ca346888af10ae90e6e3c4740b1495
https://doi.org/10.1038/s41590-022-01378-w
https://doi.org/10.1038/s41590-022-01378-w
Autor:
D. Arrouays, A. C. Richer-de-Forges, A. B. McBratney, A. E. Hartemink, B. Minasny, I. Savin, M. Grundy, J. G. B. Leenaars, L. Poggio, P. Roudier, Z. Libohova, N. J. McKenzie, H. van den Bosch, B. Kempen, V. L. Mulder, M. Lacoste, S. Chen, N. P. A. Saby, M. P. Martin, M. Román Dobarco, I. Cousin, T. Loiseau, S. Lehmann, M. Caubet, B. Lemercier, C. Walter, E. Vaudour, C. Gomez, G. Martelet, P. Krasilnikov, P. Lagacherie
Publikováno v:
Бюллетень Почвенного института им. В.В. Докучаева, Vol 0, Iss 95, Pp 3-23 (2018)
Soils have critical relevance to global issues, such as food and water security, climate regulation, sustainable energy, desertification and biodiversity protec-tion. As a consequence, soil is becoming one of the top priorities for the global environ
Externí odkaz:
https://doaj.org/article/9f6e632c49d340fa8277a42640a2ed03
Autor:
Jhuma Pramanik, Xi Chen, Gozde Kar, Johan Henriksson, Tomás Gomes, Jong-Eun Park, Kedar Natarajan, Kerstin B. Meyer, Zhichao Miao, Andrew N. J. McKenzie, Bidesh Mahata, Sarah A. Teichmann
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-19 (2018)
Abstract Background The IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfolded protein response. The pathway is indispensable for the development of secretory cells by facilitating protein folding and enhancing secretory capacity. In the
Externí odkaz:
https://doaj.org/article/f95b844f84f847589b358b382164e059
Autor:
Sara Trabanelli, Mathieu F. Chevalier, Amaia Martinez-Usatorre, Alejandra Gomez-Cadena, Bérengère Salomé, Mariangela Lecciso, Valentina Salvestrini, Grégory Verdeil, Julien Racle, Cristina Papayannidis, Hideaki Morita, Irene Pizzitola, Camille Grandclément, Perrine Bohner, Elena Bruni, Mukul Girotra, Rani Pallavi, Paolo Falvo, Elisabeth Oppliger Leibundgut, Gabriela M. Baerlocher, Carmelo Carlo-Stella, Daniela Taurino, Armando Santoro, Orietta Spinelli, Alessandro Rambaldi, Emanuela Giarin, Giuseppe Basso, Cristina Tresoldi, Fabio Ciceri, David Gfeller, Cezmi A. Akdis, Luca Mazzarella, Saverio Minucci, Pier Giuseppe Pelicci, Emanuela Marcenaro, Andrew N. J. McKenzie, Dominique Vanhecke, George Coukos, Domenico Mavilio, Antonio Curti, Laurent Derré, Camilla Jandus
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Group 2 innate lymphoid cells (ILC2s) modulate inflammatory and allergic responses, but their function in cancer immunity is still unclear. Here the authors show that, in acute promyelocytic leukaemia, tumour-activated ILC2s secrete IL-13 to induce m
Externí odkaz:
https://doaj.org/article/acd6edf30f5b42e78199d6bb93f923c9