Zobrazeno 1 - 10 of 78 pro vyhledávání: '"A N, Shatrova"'
1
Akademický článek
Characterization and Physiological Differences of Two Primary Cultures of Human Normal and Hypertrophic Scar Dermal Fibroblasts: A Pilot Study
Autor: Natalia M. Yudintceva, Yulia V. Kolesnichenko, Alla N. Shatrova, Nikolay D. Aksenov, Natalia M. Yartseva, Maxim A. Shevtsov, Viacheslav S. Fedorov, Mikhail G. Khotin, Rustam H. Ziganshin, Natalia A. Mikhailova
Publikováno v: Biomedicines, Vol 12, Iss 10, p 2295 (2024)
Background/Objectives: Dermal fibroblasts (DFs) are key participants in skin hypertrophic scarring, and their properties are being studied to identify the molecular and cellular mechanisms underlying the pathogenesis of skin scarring. Methods: In the
Externí odkaz: https://doaj.org/article/20e336da03774ea599472eddd1daacf5
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2
Akademický článek
Oncogene-Induced Senescence Is a Crucial Antitumor Defense Mechanism of Human Endometrial Stromal Cells
Autor: Artem L. Toropov, Pavel I. Deryabin, Alla N. Shatrova, Aleksandra V. Borodkina
Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 18, p 14089 (2023)
Being the major cellular component of highly dynamic tissue, endometrial stromal cells (EnSCs) are exposed to cycles of proliferation upon hormonal stimulation, which might pose risks for the accumulation of mutations and malignization. However, endo
Externí odkaz: https://doaj.org/article/e3bfddc1a59b412c99e17d852442e47b
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3
Akademický článek
Mesenchymal Stem/Stromal Cells in Three-Dimensional Cell Culture: Ion Homeostasis and Ouabain-Induced Apoptosis
Autor: Alla N. Shatrova, Alisa P. Domnina, Natalia A. Pugovkina, Larisa L. Alekseenko, Irina I. Marakhova
Publikováno v: Biomedicines, Vol 11, Iss 2, p 301 (2023)
This study describes the changes in ion homeostasis of human endometrial mesenchymal stem/stromal cells (eMSCs) during the formation of three-dimensional (3D) cell structures (spheroids) and investigates the conditions for apoptosis induction in 3D e
Externí odkaz: https://doaj.org/article/0316f5c830bc458b899d129dc8c1239b
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4
Akademický článek
Targeting Multiple Homeostasis-Maintaining Systems by Ionophore Nigericin Is a Novel Approach for Senolysis
Autor: Pavel I. Deryabin, Alla N. Shatrova, Aleksandra V. Borodkina
Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 22, p 14251 (2022)
Within the present study we proposed a novel approach for senolysis based on the simultaneous disturbance of the several homeostasis-maintaining systems in senescent cells including intracellular ionic balance, energy production and intracellular uti
Externí odkaz: https://doaj.org/article/99a74eaa20f54b49aaa52fec7fe7a429
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8
Akademický článek
Outcomes of Deferoxamine Action on H2O2-Induced Growth Inhibition and Senescence Progression of Human Endometrial Stem Cells
Autor: Alla N. Shatrova, Elena B. Burova, Marianna V. Kharchenko, Irina S. Smirnova, Olga G. Lyublinskaya, Nikolay N. Nikolsky, Aleksandra V. Borodkina
Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 11, p 6035 (2021)
Mesenchymal stem cells (MSCs) are broadly applied in regenerative therapy to replace cells that are lost or impaired during disease. The low survival rate of MSCs after transplantation is one of the major limitations heavily influencing the success o
Externí odkaz: https://doaj.org/article/6466455f786a4073892a5d5df48671c2
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9
Apoptosis resistance of senescent cells is an intrinsic barrier for senolysis induced by cardiac glycosides
Autor: Pavel Deryabin, Alla N. Shatrova, Aleksandra Borodkina
Publikováno v: Cellular and Molecular Life Sciences
Graphic abstract Targeted elimination of senescent cells, senolysis, is one of the core trends in the anti-aging therapy. Cardiac glycosides were recently proved to be a broad-spectrum senolytics. Here we tested senolytic properties of cardiac glycos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5bf0d57411a98d49a9c74270f282260
https://doi.org/10.1007/s00018-021-03980-x
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10
Akademický článek
Time-Dependent Regulation of IL-2R α-Chain (CD25) Expression by TCR Signal Strength and IL-2-Induced STAT5 Signaling in Activated Human Blood T Lymphocytes.
Autor: Alla N Shatrova, Elena V Mityushova, Irina O Vassilieva, Nikolay D Aksenov, Valery V Zenin, Nikolay N Nikolsky, Irina I Marakhova
Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0167215 (2016)
The expression of the IL-2R α-chain (IL-2Rα) is regulated at the transcriptional level via TCR- and IL-2R-signaling. The question is how to precede in time the activation signals to induce the IL-2Rα expression in native primary T cells. By compar
Externí odkaz: https://doaj.org/article/a6b99ebdd75c464ab620b5e0831206b5
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