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Akademický článek

Central lung gene expression associates with myofibroblast features in idiopathic pulmonary fibrosis

Autor: Imre Noth, Yong Huang, Aliya N Husain, Shwu-Fan Ma, Jonathan Jou, Rob Guzy, Catherine A Bonham, Jefree J Schulte, John S Kim, Andrew J Barros, Milena S Espindola, Cory M Hogaboam, Anne I Sperling

Publikováno v: BMJ Open Respiratory Research, Vol 10, Iss 1 (2023)

Rationale Contribution of central lung tissues to pathogenesis of idiopathic pulmonary fibrosis (IPF) remains unknown.Objective To ascertain the relationship between cell types of IPF-central and IPF-peripheral lung explants using RNA sequencing (RNA

Externí odkaz: https://doaj.org/article/8ec06459ed0948489a762ccc76c5dcd7

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Akademický článek

Deep learning generates synthetic cancer histology for explainability and education

Publikováno v: npj Precision Oncology, Vol 7, Iss 1, Pp 1-13 (2023)

Abstract Artificial intelligence methods including deep neural networks (DNN) can provide rapid molecular classification of tumors from routine histology with accuracy that matches or exceeds human pathologists. Discerning how neural networks make th

Externí odkaz: https://doaj.org/article/90c8d0f480c347d78a0bdd3a1cd68a11

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Akademický článek

Uncertainty-informed deep learning models enable high-confidence predictions for digital histopathology

Autor: James M. Dolezal, Andrew Srisuwananukorn, Dmitry Karpeyev, Siddhi Ramesh, Sara Kochanny, Brittany Cody, Aaron S. Mansfield, Sagar Rakshit, Radhika Bansal, Melanie C. Bois, Aaron O. Bungum, Jefree J. Schulte, Everett E. Vokes, Marina Chiara Garassino, Aliya N. Husain, Alexander T. Pearson

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Safe clinical deployment of deep learning models for digital pathology requires reliable estimates of predictive uncertainty. Here the authors describe an algorithm for quantifying whole-slide image uncertainty, demonstrating their approach with mode

Externí odkaz: https://doaj.org/article/3782f0100a0e42dd916744ca0dcd64bc

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Akademický článek

Culturally adapted psychoeducation for bipolar disorder in a low-resource setting: protocol for a multicentre randomized controlled trial

Publikováno v: European Psychiatry, Vol 66, Pp S384-S384 (2023)

Introduction Bipolar disorder (BD) is a source of marked disability, morbidity, and premature death. There is a paucity of research on personalized psychosocial interventions for BD, especially in lowresource settings. A previously published pilot ra

Externí odkaz: https://doaj.org/article/36e90d9f46674ec6a3b945dbf23d87bc

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Akademický článek

Partner inclusive parenting intervention: Evidence of a culturally adapted low-cost group psychosocial intervention for depressed fathers

Autor: M. I. Husain, A. B. Khoso, T. Kiran, M. W. Wan, Z. Zadeh, R. Sattar, N. Khan, I. B. Chaudhry, R. Memon, S. F. Jafri, Z. H. Suhag, K. Lovell, N. Husain, N. Chaudhry

Publikováno v: European Psychiatry, Vol 66, Pp S841-S841 (2023)

Introduction Depression is the leading cause of disability worldwide and low and middle-income countries (LMICs) carry over 80% of this disease burden. Attempts have been made to address depression in LMICs, with improvements in the home environment

Externí odkaz: https://doaj.org/article/52a48a73b071411692acfa21746baec3

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Akademický článek

Saving and Empowering young lives in PAKistan (SEPAK): An Exploratory Cluster Randomized Controlled Trial (cRCT)

Autor: M. Panagioti, T. Kiran, S. Irshad, R. Sattar, A. Hodkinson, S. Tofique, N. Tyler, I. Angelakis, Z. Zadeh, A. Maqsood, S. Sultana, S. Dawood, M. Bhattia, A. Tamiduddin Nizami, H. A. Khan, I. B. Chaudhry, N. Husain, N. Chaudhry

Publikováno v: European Psychiatry, Vol 66, Pp S317-S317 (2023)

Introduction Suicide is a leading cause of death among young people and most deaths by suicide occur in low and middle-income countries. School is the best place where we can identify and respond to youth suicide risk. School-based interventions for

Externí odkaz: https://doaj.org/article/6046de18a66d4aabaff7cffe96059dbc

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Akademický článek

Journey of young self-harm survivors from being vulnerable to resilient: Participants’ perspective on a culturally-adapted self-harm prevention intervention

Autor: N. Chaudhry, S. Tofique, T. Kiran, I. B. Chaudhry, N. Husain, E. Colucci

Publikováno v: European Psychiatry, Vol 66, Pp S1113-S1113 (2023)

Introduction Repeated self-harm represents the single strongest risk factor for suicide. Worldwide, suicide is the second leading cause of death in young people aged 15-29 year, and the leading cause of death in many Asian countries. Objectives This

Externí odkaz: https://doaj.org/article/cdc34973df4547de995cda682160a00d

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Akademický článek

Psychosocial and Physical Rehabilitation of Burn Survivors: A large multicentre cluster randomised controlled trial from Pakistan

Publikováno v: European Psychiatry, Vol 66, Pp S906-S906 (2023)

Introduction Globally, burns are responsible for around 11 million injuries and 180 000 burn-related deaths yearly. Unfortunately, 9 of 10 burn injuries and deaths happen in low-and-middle-income countries (LMICs) such as Pakistan. One in three peopl

Externí odkaz: https://doaj.org/article/a5f8c478fe5044aa9943d0b4dfa221e1

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Akademický článek

Measurement-based care vs. standard care for major depressive disorder in Pakistan: protocol for a randomized control trial

Publikováno v: European Psychiatry, Vol 66, Pp S836-S836 (2023)

Introduction Low and middle-income countries (LMICs) hold the majority of disease burden attributed to major depressive disorder (MDD). Despite this, there remains a substantial gap for access to evidence-based treatments for MDD in LMICs like Pakist

Externí odkaz: https://doaj.org/article/b10168cf944f4910968e08e7f4094ed6

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