Muscarinic receptor agonist-induced βPix binding to β-catenin promotes colon neoplasia

Autor: Kunrong Cheng, Ahmed Chahdi, Shannon M. Larabee, Mazen Tolaymat, Margaret H. Sundel, Cinthia B. Drachenberg, Min Zhan, Shien Hu, Anan H. Said, Aaron C. Shang, Guofeng Xie, Madeline Alizadeh, Natalia Sampaio Moura, Andrea C. Bafford, Richelle T. Williams, Nader N. Hanna, Jean-Pierre Raufman

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)

Abstract M3 muscarinic receptors (M3R) modulate β-catenin signaling and colon neoplasia. CDC42/RAC guanine nucleotide exchange factor, βPix, binds to β-catenin in colon cancer cells, augmenting β-catenin transcriptional activity. Using in silico,

Externí odkaz: https://doaj.org/article/70b4da240da844c3a6164a3fb1096cf6

The use of telemedicine for perioperative pain management during the COVID-19 pandemic.

Autor: Xie, Anping, Hsu, Yea-Jen, Speed, Traci J, Saunders, Jamia, Nguyen, Jaclyn, Khasawneh, Amro, Kim, Samuel, A Marsteller, Jill, M McDonald, Eileen, Shechter, Ronen, N Hanna, Marie

Publikováno v: Journal of Telemedicine & Telecare; Dec2024, Vol. 30 Issue 10, p1607-1617, 11p

StarGazer: A Hybrid Intelligence Platform for Drug Target Prioritization and Digital Drug Repositioning Using Streamlit

Autor: Chiyun Lee, Junxia Lin, Andrzej Prokop, Vancheswaran Gopalakrishnan, Richard N. Hanna, Eliseo Papa, Adrian Freeman, Saleha Patel, Wen Yu, Monika Huhn, Abdul-Saboor Sheikh, Keith Tan, Bret R. Sellman, Taylor Cohen, Jonathan Mangion, Faisal M. Khan, Yuriy Gusev, Khader Shameer

Publikováno v: Frontiers in Genetics, Vol 13 (2022)

Target prioritization is essential for drug discovery and repositioning. Applying computational methods to analyze and process multi-omics data to find new drug targets is a practical approach for achieving this. Despite an increasing number of metho

Externí odkaz: https://doaj.org/article/e8f1ad335c164cdfb704fd8b0dec38dc

Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study

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L Carvalho, R Garrido, A Puppo, A Guimarães, E Santos, M Kamal, M Denning, M Elhadi, J E Fitzgerald, D Miller, M Gowda, C Morris, A Phillips, H Yang, Y Zhang, N Machairas, A Fisher, A Kaufmann, A Aggarwal, L Hansen, M Otify, H Soleymani Majd, A Jones, M Rodrigues, S Sundar, C Jones, R Edmondson, A Sharkey, L Smith, G Williams, J Dunning, E Belcher, D Stavroulias, V Zamvar, M Patel, M Baker, R Evans, M Sherif, J Hopkins, R Mohammed, A Hill, H Jackson, G Jones, K George, J Dixon, A Tong, S Jallad, Deborah S Keller, A Pereira, L Elliott, D Ford, A Sermon, M Almond, Andrew Metcalfe, C Peluso, T White, S Shah, A Witek, Chetan Khatri, A Tiwari, T Lo, K Agarwal, C Sweeney, C Hart, T Holme, S Green, I Ahmed, A Sobti, C Anderson, N Modi, R Campbell, C Magee, M Mirza, D Jones, N Stylianides, X Luo, C Kang, J Ribeiro, L Kumar, J Diaz, A Bhalla, R Young, C Perkins, A James, A Walters, J Reid, R Pereira, C McDonald, A Aujayeb, K Jackson, M Allen, D Ghosh, M Chan, C Price, K Khan, R Moore, M 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Shugaba, GP Jones, SS Tripathi, MS Greenhalgh, H Emerson, K Vejsbjerg, W McCormick, K Singisetti, Y Aawsaj, R Vanker, M Ghobrial, S Kanthasamy, H Fawi, M Awadallah, J Cheung, S Tingle, F Abbadessa, A Sachdeva, CD Chan, I McPherson, F Mahmoud Ali, S Pandanaboyana, T Grainger, S Nandhra, N Dawe, C McCaffer, J Riches, J Moir, H Elamin Ahmed, C Saleh, RM Koshy, LJ Rogers, PL Labib, N Hope, K Emslie, P Panahi, E Clough, I Enemosah, J Natale, N Raza, JI Webb, M Antar, J Noel, R Nunn, F Eriberto, R Tanna, S Lodhia, C Osório, J Antunes, P Balau, M Godinho

Publikováno v: BMJ Open, Vol 11, Iss 11 (2021)

Objectives Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. Thi

Externí odkaz: https://doaj.org/article/17d582d4e77546948b853d028b0f1db7

Outcomes and Resource Utilization Associated with Use of Routine Pre-Discharge White Blood Cell Count for Clinical Decision-Making in Children with Complicated Appendicitis: A Multicenter Hospital-Level Analysis

Autor: Shannon L. Cramm, Dionne A. Graham, Martin L. Blakely, Nicole M. Chandler, Robert A. Cowles, Shaun M. Kunisaki, Robert T. Russell, Myron Allukian, Jennifer R. DeFazio, Cornelia L. Griggs, Matthew T. Santore, Stefan Scholz, Danielle I. Aronowitz, Brendan T. Campbell, Devon T. Collins, Sarah J. Commander, Abigail Engwall-Gill, Joseph R. Esparaz, Christina Feng, Claire Gerall, David N. Hanna, Olivia A. Keane, Abdulraouf Lamoshi, Aaron M. Lipskar, Claudia P. Orlas Bolanos, Elizabeth Pace, Maia D. Regan, Elisabeth T. Tracy, Sacha Williams, Lucy Zhang, Shawn J. Rangel

Publikováno v: Journal of Pediatric Surgery. 58:1178-1184

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::167f70ce2253971731220af6e1d7d1cd
https://doi.org/10.1016/j.jpedsurg.2023.02.039